Reactome | CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol

Schema > Reaction > Entries

CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol Show undefined attributes

authored	[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
catalystActivity	[CatalystActivity:192037] steroid hydroxylase activity of CYP27A1 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:193768] D'Eustachio, P, 2007-02-23 20:48:08
dbId	193792
displayName	CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol
edited	[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
eventOf	[Pathway:R-HSA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Homo sapiens
followingEvent	[Reaction:R-HSA-193719] 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al - Homo sapiens
input	[SimpleEntity:R-ALL-193720] 5?-CHOL3?,7?,24(s)-triol [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:192197] Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. [LiteratureReference:193487] Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis [LiteratureReference:193375] Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways
modified	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
name	CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol 5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol 5beta-cholestan-3alpha,7alpha,24(S)-triol + NADPH + H+ + O2 => 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol + NADP+ + H2O
orthologousEvent	[Reaction:R-SSC-193792] CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol - Sus scrofa [Reaction:R-BTA-193792] CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol - Bos taurus [Reaction:R-CFA-193792] CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol - Canis familiaris [Reaction:R-RNO-193792] CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol - Rattus norvegicus [Reaction:R-MMU-193792] CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol - Mus musculus
output	[SimpleEntity:R-ALL-193708] 5bCHOL3a,7a,24(s),27-tetrol [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-193715] 5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix - Homo sapiens
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-193792
summation	[Summation:193751] 5?-cholestan-3?,7?,24(S)-triol, NADPH + H+, and O2 react to ...

Referrals

(hasEvent)	[Pathway:R-HSA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol
(precedingEvent)	[Reaction:R-HSA-193719] 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al
(normalReaction)	[FailedReaction:R-HSA-9035960] Defective CYP27A1 does not 27-hydroxylate 5?-CHOL3?,7?,24(s)-triol

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