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author	[Person:192138] Russell, DW
created	[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
dbId	192080
displayName	The enzymes, regulation, and genetics of bile acid synthesis
journal	Annu Rev Biochem
pages	137-74
pubMedIdentifier	12543708
schemaClass	LiteratureReference
title	The enzymes, regulation, and genetics of bile acid synthesis
url	http://www.ncbi.nlm.nih.gov/pubmed/12543708
volume	72
year	2003

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[Pathway:R-HSA-8957322] Metabolism of steroids
[Pathway:R-HSA-194068] Bile acid and bile salt metabolism
[Pathway:R-HSA-192105] Synthesis of bile acids and bile salts
[Pathway:R-HSA-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol
[Pathway:R-HSA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol
[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
[BlackBoxEvent:R-HSA-193399] Cholate is translocated from the peroxisomal matrix to the cytosol
[Summation:193515] The peroxisomal matrix enzyme acyl-coenzyme A thioesterase 8...
[Summation:192328] The bile salts glycocholate, glycochenodeoxycholate, tauroch...
[BlackBoxEvent:R-HSA-192315] Bile salts are translocated from the peroxisomal matrix to the cytosol
[Summation:192354] Choloyl CoA reacts with glycine or taurine to form glycochol...
[Summation:192301] 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA and...
[Summation:193489] 25(R) THCA-CoA is transported from the cytosol into the pero...
[BlackBoxEvent:R-HSA-192325] 25(R) THCA-CoA is translocated from the cytosol to the peroxisome
[Summation:191966] THCA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate) ...
[BlackBoxEvent:R-HSA-191971] THCA is translocated from the mitochondrial matrix to the cytosol
[Reaction:R-HSA-193832] 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix
[Summation:193825] 5Beta-cholesten-7alpha,12a,27-triol-3-one and NADPH + H+ for...
[Summation:193822] 4-Cholesten-7alpha,12alpha,27-triol-3-one and NADPH + H+ rea...
[BlackBoxEvent:R-HSA-193761] 25(R) TetraHCA-CoA is translocated from the cytosol to the peroxisome
[Summation:193710] TetraHCA (3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cho...
[BlackBoxEvent:R-HSA-193722] TetraHCA is translocated from the mitochondrial matrix to the cytosol
[Reaction:R-HSA-193774] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix
[Summation:193749] 5Beta-cholesten-7alpha,12alpha,24(S)-triol-3-one and NADPH +...
[Summation:193790] 4-cholesten-7alpha,12alpha,24(S)-triol-3-one and NADPH + H+ ...
[Summation:193501] Chenodeoxycholoyl CoA reacts with glycine or taurine to form...
[Summation:193527] 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA and CoASH re...
[Summation:193507] 25(R) DHCA-CoA is transported from the cytosol into the pero...
[BlackBoxEvent:R-HSA-193482] 25(R) DHCA-CoA is translocated from the cytosol to the peroxisome
[Summation:193373] DHCA (3alpha, 7alpha-dihydroxy-5beta-cholestanoate) is trans...
[BlackBoxEvent:R-HSA-193519] DHCA is translocated from the mitochondrial matrix to the cytosol
[Reaction:R-HSA-193537] 5beta-cholestan-3alpha, 7alpha-diol is translocated from the cytosol to the mitochondrial matrix
[Summation:192057] 5Beta-cholesten-7alpha-ol-3-one and NADPH + H+ form 5beta-ch...
[Summation:192066] 4-Cholesten-7alpha-ol-3-one, NADPH, and H+ react to form 5be...
[Reaction:R-HSA-193808] 5beta-cholestan-3alpha,7alpha,27-triol is translocated from the cytosol to the mitochondrial matrix
[Summation:193811] 5Beta-cholesten-7alpha,27-diol-3-one and NADPH + H+ form 5be...
[Summation:193847] 4-Cholesten-7alpha,27-diol-3-one, NADPH, and H+ react to for...
[BlackBoxEvent:R-HSA-193753] 3,7,24THCA-CoA is translocated from the cytosol to the peroxisome
[Summation:193765] 3,7,24THCA (3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoa...
[BlackBoxEvent:R-HSA-193786] 3,7,24THCA is translocated from the mitochondrial matrix to the cytosol
[Reaction:R-HSA-192010] 5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix
[Summation:193826] 5Beta-cholesten-7alpha,12alpha-diol-3-one and NADPH + H+ for...
[Summation:192052] 4-Cholesten-7alpha, 12alpha-diol-3-one and NADPH + H+ react ...
[Reaction:R-HSA-193715] 5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix
[Summation:193759] 5Beta-cholesten-7alpha,24(S)-diol-3-one and NADPH + H+ form ...
[Summation:193742] 4-Cholesten-7alpha,24(S)-diol-3-one, NADPH, and H+ react to ...
[CatalystActivityReference:9948410] alcohol transmembrane transporter activity of unknown START protein [mitochondrial inner membrane] The enzymes, regulation, and genetics of bile acid synthesis
[Summation:192159] Cholesterol, NADPH + H+, and O2 form 7alpha-cholesterol (5-c...

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[Person:192138] Russell, DW

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