Reactome | CYP39A1 7-hydroxylates 24OH-CHOL

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CYP39A1 7-hydroxylates 24OH-CHOL Show undefined attributes

authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:192129] oxysterol 7-alpha-hydroxylase activity of CYP39A1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
crossReference	[DatabaseIdentifier:9907750] RHEA:46125
dbId	192178
displayName	CYP39A1 7-hydroxylates 24OH-CHOL
edited	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
eventOf	[Pathway:R-HSA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Homo sapiens [Pathway:R-HSA-211976] Endogenous sterols - Homo sapiens
followingEvent	[Reaction:R-HSA-193789] Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one - Homo sapiens
input	[SimpleEntity:R-ALL-192060] 24OH-CHOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191969] Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CYP39A1 7-hydroxylates 24OH-CHOL (24S)-hydroxycholesterol + O2 + reduced (NADPH--hemoprotein reductase) => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase) 24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol 24-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
orthologousEvent	[Reaction:R-GGA-192178] CYP39A1 7-hydroxylates 24OH-CHOL - Gallus gallus [Reaction:R-XTR-192178] CYP39A1 7-hydroxylates 24OH-CHOL - Xenopus tropicalis [Reaction:R-DRE-192178] CYP39A1 7-hydroxylates 24OH-CHOL - Danio rerio [Reaction:R-SSC-192178] CYP39A1 7-hydroxylates 24OH-CHOL - Sus scrofa [Reaction:R-BTA-192178] CYP39A1 7-hydroxylates 24OH-CHOL - Bos taurus [Reaction:R-CFA-192178] CYP39A1 7-hydroxylates 24OH-CHOL - Canis familiaris [Reaction:R-RNO-192178] CYP39A1 7-hydroxylates 24OH-CHOL - Rattus norvegicus [Reaction:R-MMU-192178] CYP39A1 7-hydroxylates 24OH-CHOL - Mus musculus
output	[SimpleEntity:R-ALL-192189] CHOL7a,24(S)DIOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-193767] Influx of 24-hydroxycholesterol - Homo sapiens
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-192178
summation	[Summation:192109] 24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1), located...
updateTrackers	[UpdateTracker:9785999] Update Tracker - [Reaction:192178] CYP39A1 7-hydroxylates 24OH-CHOL - v50:[modifyText]

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(updatedInstance)	[UpdateTracker:9785999] Update Tracker - [Reaction:192178] CYP39A1 7-hydroxylates 24OH-CHOL - v50:[modifyText]
(hasEvent)	[Pathway:R-HSA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol [Pathway:R-HSA-211976] Endogenous sterols
(precedingEvent)	[Reaction:R-HSA-193789] Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one

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