Reactome | CREBBP [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

CREBBP [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:9825749] protein-lysine-acetyltransferase activity of CREBBP [nucleoplasm] [CatalystActivity:3697003] histone acetyltransferase activity of CREBBP [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-381367] PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] - Homo sapiens [Complex:R-HSA-9038050] GREB1:ESR1:ESTG:EP300:CREBBP [nucleoplasm] - Homo sapiens [Complex:R-HSA-9922977] p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER2 gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-2220989] NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] - Homo sapiens [Complex:R-HSA-1604462] NOTCH1 Coactivator Complex [nucleoplasm] - Homo sapiens [Complex:R-HSA-5617861] atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-3927959] SUMOylation of CREBBP with SUMO1 - Homo sapiens [Reaction:R-HSA-9833446] NS1 (1C) binds to CREBBP - Homo sapiens [Reaction:R-HSA-381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - Homo sapiens [Reaction:R-HSA-9929319] p-90-BMAL1:p-T451,T461-CLOCK and coactivators bind the DBP gene - Homo sapiens [Reaction:R-HSA-9922982] p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the PER1 gene - Homo sapiens [BlackBoxEvent:R-HSA-1234167] Formation of HIF:CBP:p300 complex at promoters - Homo sapiens [Reaction:R-HSA-6797993] TP53 and CREBBP bind BNIP3L gene - Homo sapiens [Reaction:R-HSA-8938231] RUNX1:CBFB binds CREBBP - Homo sapiens [Reaction:R-HSA-9626928] CREBBP binds FOXO1 - Homo sapiens [Reaction:R-HSA-9922998] p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the PER2 gene - Homo sapiens [Reaction:R-HSA-9816396] DUX4, TPRXL, TPRX1, TPRX2, EP300, and CREBBP bind the ZSCAN4 gene - Homo sapiens [Reaction:R-HSA-9925862] p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the RORC gene - Homo sapiens [Reaction:R-HSA-9923010] p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene - Homo sapiens [Reaction:R-HSA-9925650] p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the CRY2 gene - Homo sapiens [Reaction:R-HSA-9909400] p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the PER3 gene - Homo sapiens [Reaction:R-HSA-9038052] GREB1 binds ESR1:ESTG and co-activators - Homo sapiens [Reaction:R-HSA-2220964] NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML - Homo sapiens [Reaction:R-HSA-8864307] TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP - Homo sapiens [BlackBoxEvent:R-HSA-5617896] Retinoic acid activates HOXD4 chromatin - Homo sapiens [Reaction:R-HSA-1912394] NICD1 in complex with RBPJ (CSL) recruits MAML - Homo sapiens [Reaction:R-HSA-212356] Formation of CSL-NICD coactivator complex - Homo sapiens [Reaction:R-HSA-9976117] STAT6, NFATC2 (NFAT1), and NICD1,2 bind the GATA3 gene and cause displacement of repressor complexes (PRC1, RBPJ:NCOR) by activator complexes (MLL1, RBPJ:NICD1,2) - Homo sapiens
created	[InstanceEdit:193555] Jassal, B, 2007-02-20 12:51:13
dbId	193545
deleted	[Deleted:9005370] Deletion of instance: 212328
displayName	CREBBP [nucleoplasm]
endCoordinate	2442
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-193545] CREBBP [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-193545] CREBBP [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-193545] CREBBP [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-193545] CREBBP [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-193545] CREBBP [nucleoplasm] - Sus scrofa [GenomeEncodedEntity:R-XTR-193545] Ghost homologue of CREBBP [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-193545] CREBBP [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DME-193545] nej [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-193545] CREBBP [nucleoplasm] - Caenorhabditis elegans
maxDepth	1
memberOf	[DefinedSet:R-HSA-400216] Coactivators of PPARalpha [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:3769434] Orlic-Milacic, M, 2013-06-20
name	CREBBP CREB-binding protein CBP_HUMAN KAT3A
negativelyRegulates	[NegativeRegulation:9907129] Negative regulation by 'CREBBP [nucleoplasm]'
positivelyRegulates	[PositiveRegulation:9769877] Positive regulation by 'CREBBP [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-9626945] CREBBP acetylates FOXO1 - Homo sapiens [Reaction:R-HSA-2220971] CDK8 phosphorylates NICD1 PEST domain mutants - Homo sapiens [Reaction:R-HSA-1912391] NICD1 is phosphorylated by CDK8 - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q92793] UniProt:Q92793 CREBBP
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-193545
startCoordinate	1
updateTrackers	[UpdateTracker:9870626] Update Tracker - [EntityWithAccessionedSequence:193545] CREBBP [nucleoplasm] - v38:[modifyName] [UpdateTracker:9888270] Update Tracker - [EntityWithAccessionedSequence:193545] CREBBP [nucleoplasm] - v46:[modifyName, modifyStartCoordinate] [UpdateTracker:9871496] Update Tracker - [EntityWithAccessionedSequence:193545] CREBBP [nucleoplasm] - v40:[addEndCoordinate, addStartCoordinate] [UpdateTracker:9884857] Update Tracker - [EntityWithAccessionedSequence:193545] CREBBP [nucleoplasm] - v45:[addName]

Referrals

(hasComponent)	[Complex:R-HSA-9038050] GREB1:ESR1:ESTG:EP300:CREBBP [nucleoplasm] [Complex:R-HSA-2220989] NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] [Complex:R-HSA-381367] PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] [Complex:R-HSA-9816378] DUX4:TPRXL:TPRX1:TPRX2:EP300:CREBBP:ZSCAN4 gene [nucleoplasm] [Complex:R-HSA-5617861] atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] [Complex:R-HSA-9977595] NOTCH1,2 Coactivator Complex [nucleoplasm] [Complex:R-HSA-9929982] p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] [Complex:R-HSA-9922977] p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER2 gene [nucleoplasm] [Complex:R-HSA-9922978] p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] [Complex:R-HSA-9922995] p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER1 gene [nucleoplasm] [Complex:R-HSA-9920693] p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm] [Complex:R-HSA-9923000] p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:PER1 gene [nucleoplasm] [Complex:R-HSA-9923023] p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:PER2 gene [nucleoplasm] [Complex:R-HSA-9923003] p-S90,Ac-K538-BMAL1:p-S,T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] [Complex:R-HSA-9922275] p-S90,Ac-K538-BMAL1:p-S,T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm] [Complex:R-HSA-9922996] p-S90,Ac-K538-BMAL1:p-S,T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER2 gene [nucleoplasm] [Complex:R-HSA-9922980] p-S90,Ac-K538-BMAL1:p-S,T451,T461,S440,S441,S446-CLOCK:KMT2A:CREBBP:PER1 gene [nucleoplasm] [Complex:R-HSA-9939303] p-S90,Ac-K538-BMAL1:p-S,T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] [Complex:R-HSA-9920712] p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm] [Complex:R-HSA-9929993] p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] [Complex:R-HSA-9922988] p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] [Complex:R-HSA-9922991] p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER2 gene [nucleoplasm] [Complex:R-HSA-9923011] p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:CREBBP:KMT2A:PER1 gene [nucleoplasm] [Complex:R-HSA-9929330] p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:DBP gene [nucleoplasm] [Complex:R-HSA-9925864] p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:RORC gene [nucleoplasm] [Complex:R-HSA-1604462] NOTCH1 Coactivator Complex [nucleoplasm] [Complex:R-HSA-2247939] CCND1:CREBBP [nucleoplasm] [Complex:R-HSA-9833449] CREBBP:NS1 [nucleoplasm] [Complex:R-HSA-1234099] HIF:CBP:p300 [nucleoplasm] [Complex:R-HSA-6797994] p-S15,S20-TP53 Tetramer:CREBBP:BNIP3L Gene [nucleoplasm] [Complex:R-HSA-9922981] p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:NR1D1 gene [nucleoplasm] [Complex:R-HSA-8938230] RUNX1:CBFB:CREBBP [nucleoplasm] [Complex:R-HSA-212451] CSL NICD coactivator complex [nucleoplasm] [Complex:R-HSA-8864321] TFAP2 homo- and heterodimers:CITED2,CITED4,(CITED1):EP300:CREBBP [nucleoplasm] [Complex:R-HSA-9626931] FOXO1:CREBBP [nucleoplasm] [Complex:R-HSA-9933423] p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2:CREBBP:KMT2A:PER2 gene [nucleoplasm] [Complex:R-HSA-9925656] p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm] [Complex:R-HSA-9909389] p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:PER3 gene [nucleoplasm] [Complex:R-HSA-9933418] p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2:CREBBP:KMT2A:PER1 gene [nucleoplasm]
(input)	[Reaction:R-HSA-9038052] GREB1 binds ESR1:ESTG and co-activators [Reaction:R-HSA-3927959] SUMOylation of CREBBP with SUMO1 [Reaction:R-HSA-2220964] NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML [Reaction:R-HSA-381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands [Reaction:R-HSA-9816396] DUX4, TPRXL, TPRX1, TPRX2, EP300, and CREBBP bind the ZSCAN4 gene [BlackBoxEvent:R-HSA-5617896] Retinoic acid activates HOXD4 chromatin [Reaction:R-HSA-9976117] STAT6, NFATC2 (NFAT1), and NICD1,2 bind the GATA3 gene and cause displacement of repressor complexes (PRC1, RBPJ:NCOR) by activator complexes (MLL1, RBPJ:NICD1,2) [Reaction:R-HSA-9929319] p-90-BMAL1:p-T451,T461-CLOCK and coactivators bind the DBP gene [Reaction:R-HSA-9922982] p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the PER1 gene [Reaction:R-HSA-9925862] p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the RORC gene [Reaction:R-HSA-1912394] NICD1 in complex with RBPJ (CSL) recruits MAML [Reaction:R-HSA-9833446] NS1 (1C) binds to CREBBP [BlackBoxEvent:R-HSA-1234167] Formation of HIF:CBP:p300 complex at promoters [Reaction:R-HSA-6797993] TP53 and CREBBP bind BNIP3L gene [Reaction:R-HSA-9923010] p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the NR1D1 (REV-ERBA) gene [Reaction:R-HSA-8938231] RUNX1:CBFB binds CREBBP [Reaction:R-HSA-212356] Formation of CSL-NICD coactivator complex [Reaction:R-HSA-8864307] TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP [Reaction:R-HSA-9626928] CREBBP binds FOXO1 [Reaction:R-HSA-9922998] p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the PER2 gene [Reaction:R-HSA-9925650] p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the CRY2 gene [Reaction:R-HSA-9909400] p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the PER3 gene
(output)	[Reaction:R-HSA-2220971] CDK8 phosphorylates NICD1 PEST domain mutants [Reaction:R-HSA-1912391] NICD1 is phosphorylated by CDK8 [Reaction:R-HSA-9626945] CREBBP acetylates FOXO1
(hasMember)	[DefinedSet:R-HSA-400216] Coactivators of PPARalpha [nucleoplasm] [DefinedSet:R-HSA-1027362] CREBBP,EP300 [nucleoplasm]
(activeUnit)	[NegativeRegulation:9907129] Negative regulation by 'CREBBP [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5634091] Positive gene expression regulation by 'atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-6798006] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:CREBBP:BNIP3L Gene [nucleoplasm]' [CatalystActivity:9626949] protein-lysine-acetyltransferase activity of FOXO1:CREBBP [nucleoplasm]
(physicalEntity)	[CatalystActivity:9825749] protein-lysine-acetyltransferase activity of CREBBP [nucleoplasm] [CatalystActivity:3697003] histone acetyltransferase activity of CREBBP [nucleoplasm]
(regulator)	[NegativeRegulation:9907129] Negative regulation by 'CREBBP [nucleoplasm]' [PositiveRegulation:9769877] Positive regulation by 'CREBBP [nucleoplasm]'
(replacementInstances)	[Deleted:9005370] Deletion of instance: 212328
(updatedInstance)	[UpdateTracker:9870626] Update Tracker - [EntityWithAccessionedSequence:193545] CREBBP [nucleoplasm] - v38:[modifyName] [UpdateTracker:9888270] Update Tracker - [EntityWithAccessionedSequence:193545] CREBBP [nucleoplasm] - v46:[modifyName, modifyStartCoordinate] [UpdateTracker:9871496] Update Tracker - [EntityWithAccessionedSequence:193545] CREBBP [nucleoplasm] - v40:[addEndCoordinate, addStartCoordinate] [UpdateTracker:9884857] Update Tracker - [EntityWithAccessionedSequence:193545] CREBBP [nucleoplasm] - v45:[addName]

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