Reactome | CREBBP,EP300 [nucleoplasm]

Schema > DefinedSet > Entries

CREBBP,EP300 [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:5083648] protein N-acetyltransferase activity of CREBBP,EP300 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-1027360] VAF (virus-activated factor) [nucleoplasm] - Homo sapiens [Complex:R-HSA-1027364] p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 [nucleoplasm] - Homo sapiens [Complex:R-HSA-9854001] Activated p-Y78,Y102-PPARG2:RXRA:ACSS3 gene:nucleosomes [nucleoplasm] - Homo sapiens [Complex:R-HSA-9854005] Activated p-Y78,Y102-PPARG2:RXRA:SCD5 gene:nucleosomes [nucleoplasm] - Homo sapiens [Complex:R-HSA-9854074] Activated p-Y78,Y102-PPARG2:RXRA:SCD5 gene:H3K4me1-nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] - Homo sapiens [Complex:R-HSA-9864875] Activated PPARG:RXRA:PDK4 gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] - Homo sapiens [Complex:R-HSA-9864801] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:PLIN4 gene:nucleosomes [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9617683] EP300,CREBBP bind SOH-C481-FOXO4 - Homo sapiens [Reaction:R-HSA-1028817] CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 - Homo sapiens [Reaction:R-HSA-1028820] Formation of VAF (virus-activated factor) complex - Homo sapiens [Reaction:R-HSA-933536] p-IRF7 dimer interacts with coactivator CBP/p300 - Homo sapiens [Reaction:R-HSA-3322427] Beta-catenin recruits CBP/p300 - Homo sapiens [Reaction:R-HSA-9760082] NFE2L2 binds CREBBP,EP300 - Homo sapiens [Reaction:R-HSA-5660666] CBP and p300 binds NF-kB complex - Homo sapiens [Reaction:R-HSA-9926478] MITF-M binds CREBBP,EP300 - Homo sapiens [Reaction:R-HSA-9622572] NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9843120] Coactivators are recruited to liganded PPARG:RXRA heterodimer - Homo sapiens [Reaction:R-HSA-3134883] Beta-catenin enhances association of IRF3 with CBP/p300 - Homo sapiens
created	[InstanceEdit:1027366] Garapati, P V, 2010-11-17
dbId	1027362
displayName	CREBBP,EP300 [nucleoplasm]
hasMember	[EntityWithAccessionedSequence:R-HSA-193545] CREBBP [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm] - Homo sapiens
inDisease	false
inferredTo	[DefinedSet:R-MMU-1027362] CREBBP,EP300 [nucleoplasm] - Mus musculus [DefinedSet:R-RNO-1027362] CREBBP,EP300 [nucleoplasm] - Rattus norvegicus [DefinedSet:R-CFA-1027362] CREBBP,EP300 [nucleoplasm] - Canis familiaris [DefinedSet:R-BTA-1027362] CREBBP,EP300 [nucleoplasm] - Bos taurus [DefinedSet:R-SSC-1027362] CREBBP,EP300 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-XTR-381325] ep300 [nucleoplasm] - Xenopus tropicalis [DefinedSet:R-GGA-1027362] CREBBP,EP300 [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DME-193545] nej [nucleoplasm] - Drosophila melanogaster [DefinedSet:R-CEL-1027362] CREBBP,EP300 [nucleoplasm] - Caenorhabditis elegans
maxDepth	2
modified	[InstanceEdit:9622578] Orlic-Milacic, Marija, 2018-10-01
name	CREBBP,EP300 CBP/p300
producedByEvent	[Reaction:R-HSA-9617758] EP300,CREBBP acetylate FOXO4 - Homo sapiens
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-1027362
updateTrackers	[UpdateTracker:9899769] Update Tracker - [DefinedSet:1027362] CREBBP,EP300 [nucleoplasm] - v67:[modifyName] [UpdateTracker:9897026] Update Tracker - [DefinedSet:1027362] CREBBP,EP300 [nucleoplasm] - v61:[addName]

Referrals

(hasComponent)	[Complex:R-HSA-9864875] Activated PPARG:RXRA:PDK4 gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9864874] Activated PPARG:RXRA:PEX11A gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9864879] Activated PPARG:RXRA:LPL gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9856480] Activated PPARG:RXRA:CEBPA gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9864867] Activated PPARG:RXRA:PLIN2 gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9851512] Activated PPARG:RXRA:PPARG gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9854074] Activated p-Y78,Y102-PPARG2:RXRA:SCD5 gene:H3K4me1-nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] [Complex:R-HSA-9864881] Activated PPARG:RXRA:ANGPTL4 gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9851511] Activated PPARG:RXRA:FABP4 gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9854070] Activated p-Y78,Y102-PPARG2:RXRA:ELOVL5 gene:H3K4me1-nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] [Complex:R-HSA-9854090] Activated p-Y78,Y102-PPARG2:RXRA:GPAM gene:H3K4me1-nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] [Complex:R-HSA-9864853] Activated PPARG:RXRA:PLIN1 gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9864801] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:PLIN4 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864800] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:LPL gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864803] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:PLIN2 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864802] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:LPIN1 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864805] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:PLIN1 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864804] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:PDK4 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864807] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:FABP4 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864806] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:PPARG gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9854041] Activated p-Y78,Y102-PPARG2:RXRA:THRSP gene:nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] [Complex:R-HSA-9864793] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:LIPE gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864792] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:ANGPTL4 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864795] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:CD36 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864794] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:PEX11A gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864797] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:ACSL1 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864796] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:DGAT2 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864799] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:SCD gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864798] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:PNPLA2 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864787] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:CEBPA gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864786] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:AGPAT2 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9854037] Activated p-Y78,Y102-PPARG2:RXRA:ELOVL5 gene:nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] [Complex:R-HSA-9854036] Activated p-Y78,Y102-PPARG2:RXRA:SCD5 gene:nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] [Complex:R-HSA-9864788] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:ADIPOQ gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864791] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:MGLL gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9854039] Activated p-Y78,Y102-PPARG2:RXRA:ACSS3 gene:nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] [Complex:R-HSA-9854038] Activated p-Y78,Y102-PPARG2:RXRA:GPAM gene:nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] [Complex:R-HSA-9864790] Activated PPARG:RXRA:MLL4,(MLL3)-ASCOM:CIDEC gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9854082] Activated p-Y78,Y102-PPARG2:RXRA:ACSS3 gene:H3K4me1-nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] [Complex:R-HSA-9864697] Activated PPARG:RXRA:ADIPOQ gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9854008] Activated p-Y78,Y102-PPARG2:RXRA:THRSP gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864699] Activated PPARG:RXRA:FABP4 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864698] Activated PPARG:RXRA:CIDEC gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864701] Activated PPARG:RXRA:CD36 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864700] Activated PPARG:RXRA:LPIN1 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864703] Activated PPARG:RXRA:LIPE gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864702] Activated PPARG:RXRA:DGAT2 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9854001] Activated p-Y78,Y102-PPARG2:RXRA:ACSS3 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9854002] Activated p-Y78,Y102-PPARG2:RXRA:ELOVL5 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9854005] Activated p-Y78,Y102-PPARG2:RXRA:SCD5 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9854006] Activated p-Y78,Y102-PPARG2:RXRA:GPAM gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864713] Activated PPARG:RXRA:SCD gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864712] Activated PPARG:RXRA:PLIN2 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864715] Activated PPARG:RXRA:PNPLA2 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864714] Activated PPARG:RXRA:PDK4 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864717] Activated PPARG:RXRA:CEBPA gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864716] Activated PPARG:RXRA:ACSL1 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864718] Activated PPARG:RXRA:PEX11A gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864705] Activated PPARG:RXRA:PLIN4 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864704] Activated PPARG:RXRA:PLIN1 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864707] Activated PPARG:RXRA:MGLL gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864709] Activated PPARG:RXRA:LPL gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864708] Activated PPARG:RXRA:ANGPTL4 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864711] Activated PPARG:RXRA:PPARG gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9864710] Activated PPARG:RXRA:AGPAT2 gene:nucleosomes [nucleoplasm] [Complex:R-HSA-9854064] Activated p-Y78,Y102-PPARG2:RXRA:THRSP gene:H3K4me1-nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] [Complex:R-HSA-9864877] Activated PPARG:RXRA:ACSL1 gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9864873] Activated PPARG:RXRA:MGLL gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9864850] Activated PPARG:RXRA:PNPLA2 gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9851509] Activated PPARG:RXRA:CD36 gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9864856] Activated PPARG:RXRA:AGPAT2 gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9851514] Activated PPARG:RXRA:CIDEC gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-1027364] p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 [nucleoplasm] [Complex:R-HSA-933471] CBP/p300:pIRF7:pIRF7 [nucleoplasm] [Complex:R-HSA-1027360] VAF (virus-activated factor) [nucleoplasm] [Complex:R-HSA-3322396] TCF/LEF:CTNNB1:CBP/p300 [nucleoplasm] [Complex:R-HSA-3134898] beta-catenin:IRF3:p300 [nucleoplasm] [Complex:R-HSA-9760062] p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm] [Complex:R-HSA-9760065] p-NFE2L2:CREBBP,EP300 [nucleoplasm] [Complex:R-HSA-5660656] NFKB1:p-S276-RELA:p300/CBP [nucleoplasm] [Complex:R-HSA-5660657] NFKB1:p-S276,5AcK-RELA:p300/CBP [nucleoplasm] [Complex:R-HSA-9622566] NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm] [Complex:R-HSA-9926393] MITF-M:CREBBP,EP300 [nucleoplasm] [Complex:R-HSA-9926400] Ac-K206 MITF-M:CREBBP,EP300 [nucleoplasm] [Complex:R-HSA-9864866] Activated PPARG:RXRA:LIPE gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9856215] Activated PPARG:RXRA:ADIPOQ gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9851516] Activated PPARG:RXRA:SCD gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9864865] Activated PPARG:RXRA:DGAT2 gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9864871] Activated PPARG:RXRA:LPIN1 gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm] [Complex:R-HSA-9864858] Activated PPARG:RXRA:PLIN4 gene:H3K4me1-Nucleosomes:MLL4,(MLL3)-ASCOM [nucleoplasm]
(input)	[BlackBoxEvent:R-HSA-9843120] Coactivators are recruited to liganded PPARG:RXRA heterodimer [Reaction:R-HSA-1028817] CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 [Reaction:R-HSA-1028820] Formation of VAF (virus-activated factor) complex [Reaction:R-HSA-933536] p-IRF7 dimer interacts with coactivator CBP/p300 [Reaction:R-HSA-3322427] Beta-catenin recruits CBP/p300 [Reaction:R-HSA-3134883] Beta-catenin enhances association of IRF3 with CBP/p300 [Reaction:R-HSA-9760082] NFE2L2 binds CREBBP,EP300 [Reaction:R-HSA-5660666] CBP and p300 binds NF-kB complex [Reaction:R-HSA-9622572] NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter [Reaction:R-HSA-9617683] EP300,CREBBP bind SOH-C481-FOXO4 [Reaction:R-HSA-9926478] MITF-M binds CREBBP,EP300
(output)	[Reaction:R-HSA-9617758] EP300,CREBBP acetylate FOXO4
(activeUnit)	[CatalystActivity:5660659] acetyltransferase activity of NFKB1:p-S276-RELA:p300/CBP [nucleoplasm] [PositiveGeneExpressionRegulation:9622623] Positive gene expression regulation by 'FOXO1,FOXO3,(FOXO4):NF-Y:CREBBP,EP300:BCL2L11 gene [nucleoplasm]' [CatalystActivity:9617754] protein-lysine-acetyltransferase activity of CREBPP-S-S-FOXO4:FOXO4-S-S-CREBBP,EP300-S-S-FOXO4:FOXO4-S-S-EP300 [nucleoplasm] [CatalystActivity:9760084] protein N-acetyltransferase activity of p-NFE2L2:CREBBP,EP300 [nucleoplasm] [CatalystActivity:9926428] histone acetyltransferase activity of MITF-M:CREBBP,EP300 [nucleoplasm]
(physicalEntity)	[CatalystActivity:5083648] protein N-acetyltransferase activity of CREBBP,EP300 [nucleoplasm]
(updatedInstance)	[UpdateTracker:9899769] Update Tracker - [DefinedSet:1027362] CREBBP,EP300 [nucleoplasm] - v67:[modifyName] [UpdateTracker:9897026] Update Tracker - [DefinedSet:1027362] CREBBP,EP300 [nucleoplasm] - v61:[addName]

© 2026 Reactome

Cite Us!