Reactome | p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the RORC gene

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p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the RORC gene Show undefined attributes

authored	[InstanceEdit:9925663] May, Bruce, 2024-10-21
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9925865] May, Bruce, 2024-10-28
dbId	9925862
displayName	p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the RORC gene
edited	[InstanceEdit:9925663] May, Bruce, 2024-10-21
eventOf	[Pathway:R-HSA-9931510] Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9925861] Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of RORC - Homo sapiens
inferredFrom	[Reaction:R-MMU-9926663] p-S97-Bmal1:p-T451,T461-Clock and coactivators bind the Rorc gene - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-193545] CREBBP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1183223] KMT2A [nucleoplasm] [Complex:R-HSA-9920661] p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8948433] RORC gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the RORC gene
output	[Complex:R-HSA-9925864] p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:RORC gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9920665] p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9925862
summation	[Summation:9930026] A phosphorylated BMAL1:CLOCK heterodimer binds a site near t...

Referrals

(hasEvent)	[Pathway:R-HSA-9931510] Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
(precedingEvent)	[BlackBoxEvent:R-HSA-9925861] Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of RORC
(inferredTo)	[Reaction:R-MMU-9926663] p-S97-Bmal1:p-T451,T461-Clock and coactivators bind the Rorc gene

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