Reactome | PPARG:RXRA heterodimer binds to fatty acid-like ligands

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PPARG:RXRA heterodimer binds to fatty acid-like ligands Show undefined attributes

authored	[InstanceEdit:420937] May, B, 2009-05-15 01:16:49
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:381302] May, B, 2008-11-19 19:18:44
dbId	381309
displayName	PPARG:RXRA heterodimer binds to fatty acid-like ligands
edited	[InstanceEdit:420937] May, B, 2009-05-15 01:16:49 [InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
eventOf	[Pathway:R-HSA-381340] Transcriptional regulation of white adipocyte differentiation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-560498] Expression of Lipoprotein lipase (LPL) - Homo sapiens [BlackBoxEvent:R-HSA-560510] Expression of FABP4 (aP2) - Homo sapiens [BlackBoxEvent:R-HSA-560473] Expression of ANGPTL4 - Homo sapiens [BlackBoxEvent:R-HSA-560472] Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) - Homo sapiens [BlackBoxEvent:R-HSA-560493] Expression of Perilipin (PLIN) - Homo sapiens [BlackBoxEvent:R-HSA-560491] Expression of CEBPA - Homo sapiens [BlackBoxEvent:R-HSA-560517] Expression of CD36 (platelet glycoprotein IV, FAT) - Homo sapiens [BlackBoxEvent:R-HSA-1183058] Expression of Adiponectin - Homo sapiens
inferredFrom	[Reaction:R-MMU-556760] Pparg:Rxra heterodimer binds to fatty acids - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-193545] CREBBP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm] 2 × [Complex:R-HSA-2026090] FABP4:Ligands of PPARG [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8940294] FAM120B [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-442499] HELZ2 [nucleoplasm] [Complex:R-HSA-556786] Mediator Complex (consensus) [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-442496] NCOA1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-376398] NCOA2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-442488] NCOA3 [nucleoplasm] [Complex:R-HSA-381226] PPARG:RXRA:Corepressor Complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-442481] PPARGC1A [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8932115] THRAP3 [nucleoplasm]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:556830] p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively [LiteratureReference:435327] A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs [LiteratureReference:435318] Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists [LiteratureReference:381354] Transcriptional control of adipocyte formation [LiteratureReference:381379] Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology [LiteratureReference:9035303] Structural basis for the activation of PPARgamma by oxidized fatty acids
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PPARG:RXRA heterodimer binds to fatty acid-like ligands
output	2 × [EntityWithAccessionedSequence:R-HSA-2026072] FABP4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-442464] HDAC3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-442501] NCOR1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-442469] NCOR2 [nucleoplasm] [Complex:R-HSA-381367] PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]
precedingEvent	[Reaction:R-HSA-381290] PPARG:RXRA heterodimer binds to PPARG corepressors - Homo sapiens
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422150] D'Eustachio, P, 2009-05-26 22:09:50 [InstanceEdit:1183001] Sethi, JK, 2011-02-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-381309
summation	[Summation:381349] PPARG can be activated in cell cultures by adding ligands su...
updateTrackers	[UpdateTracker:9782147] Update Tracker - [Reaction:381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - v59:[addInput] [UpdateTracker:9788888] Update Tracker - [Reaction:381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - v40:[addOutput, add_removeInput, modifyText] [UpdateTracker:9782713] Update Tracker - [Reaction:381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - v58:[addInput] [UpdateTracker:9779906] Update Tracker - [Reaction:381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - v64:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9782147] Update Tracker - [Reaction:381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - v59:[addInput] [UpdateTracker:9788888] Update Tracker - [Reaction:381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - v40:[addOutput, add_removeInput, modifyText] [UpdateTracker:9782713] Update Tracker - [Reaction:381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - v58:[addInput] [UpdateTracker:9779906] Update Tracker - [Reaction:381309] PPARG:RXRA heterodimer binds to fatty acid-like ligands - v64:[addLiteratureReference]
(precedingEvent)	[BlackBoxEvent:R-HSA-560498] Expression of Lipoprotein lipase (LPL) [BlackBoxEvent:R-HSA-560510] Expression of FABP4 (aP2) [BlackBoxEvent:R-HSA-560473] Expression of ANGPTL4 [BlackBoxEvent:R-HSA-560472] Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) [BlackBoxEvent:R-HSA-560517] Expression of CD36 (platelet glycoprotein IV, FAT) [BlackBoxEvent:R-HSA-560493] Expression of Perilipin (PLIN) [BlackBoxEvent:R-HSA-1183058] Expression of Adiponectin [BlackBoxEvent:R-HSA-560491] Expression of CEBPA
(hasEvent)	[Pathway:R-HSA-381340] Transcriptional regulation of white adipocyte differentiation
(inferredTo)	[Reaction:R-MMU-556760] Pparg:Rxra heterodimer binds to fatty acids

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