Reactome | Retinoic acid activates HOXD4 chromatin

Schema > BlackBoxEvent > Entries

Retinoic acid activates HOXD4 chromatin Show undefined attributes

authored	[InstanceEdit:5617432] May, Bruce, 2014-08-07 [InstanceEdit:6810137] Rezsohazy, Ren�, 2015-11-15
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5617850] May, Bruce, 2014-08-15
dbId	5617896
displayName	Retinoic acid activates HOXD4 chromatin
edited	[InstanceEdit:5617678] May, Bruce, 2014-08-13
eventOf	[Pathway:R-HSA-5617472] Activation of anterior HOX genes in hindbrain development during early embryogenesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5617874] HOXD4 gene is transcribed - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-5619441] Retinoic acid activates Hoxd4 chromatin - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-193545] CREBBP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm] [DefinedSet:R-HSA-5619379] MLL3,4 complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-442488] NCOA3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3009044] PAX6 [nucleoplasm] [Complex:R-HSA-5617895] RARA,B:RXRA at HOXD4 bivalent chromatin [nucleoplasm] [Complex:R-HSA-209680] RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5619459] In vitro and transgenic analysis of a human HOXD4 retinoid-responsive enhancer [LiteratureReference:5619449] Regulation of the human HOXD4 gene by retinoids [LiteratureReference:5619306] HOXD4 and regulation of the group 4 paralog genes [LiteratureReference:4687099] A histone H3 lysine 27 demethylase regulates animal posterior development [LiteratureReference:5619280] Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation [LiteratureReference:5687948] Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Retinoic acid activates HOXD4 chromatin
output	[Complex:R-HSA-5617861] atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-442501] NCOR1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-389115] PCGF2 [nucleoplasm] [Complex:R-HSA-212285] PRC2 (EZH2) Core [nucleoplasm]
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693642] Blasi, F, 2015-05-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5617896
summation	[Summation:5619514] As inferred from mouse embryos, retinoic acid activates the ...

Referrals

(hasEvent)	[Pathway:R-HSA-5617472] Activation of anterior HOX genes in hindbrain development during early embryogenesis
(precedingEvent)	[BlackBoxEvent:R-HSA-5617874] HOXD4 gene is transcribed
(inferredTo)	[BlackBoxEvent:R-MMU-5619441] Retinoic acid activates Hoxd4 chromatin