Reactome | CREBBP [nucleoplasm]

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CREBBP [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:10216876] protein-lysine-acetyltransferase activity of CREBBP [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-RNO-9038050] GREB1:ESR1:ESTG:EP300:CREBBP [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-8864321] TFAP2 homo- and heterodimers:CITED2,CITED4,(CITED1):EP300:CREBBP [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-212451] CSL NICD coactivator complex [nucleoplasm] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-9626928] CREBBP binds FOXO1 - Rattus norvegicus [Reaction:R-RNO-8938231] RUNX1:CBFB binds CREBBP - Rattus norvegicus [BlackBoxEvent:R-RNO-1234167] Formation of HIF:CBP:p300 complex at promoters - Rattus norvegicus [Reaction:R-RNO-9038052] GREB1 binds ESR1:ESTG and co-activators - Rattus norvegicus [Reaction:R-RNO-8864307] TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP - Rattus norvegicus [Reaction:R-RNO-212356] Formation of CSL-NICD coactivator complex - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10128612
displayName	CREBBP [nucleoplasm]
endCoordinate	2442
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-193545] CREBBP [nucleoplasm] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-RNO-1027362] CREBBP,EP300 [nucleoplasm] - Rattus norvegicus
name	CREBBP Q6JHU9
negativelyRegulates	[NegativeRegulation:10216883] Negative regulation by 'CREBBP [nucleoplasm]'
referenceEntity	[ReferenceGeneProduct:uniprot:Q6JHU9] UniProt:Q6JHU9 Crebbp
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-193545
startCoordinate	1

Referrals

(input)	[Reaction:R-RNO-9038052] GREB1 binds ESR1:ESTG and co-activators [Reaction:R-RNO-9626928] CREBBP binds FOXO1 [Reaction:R-RNO-8864307] TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP [Reaction:R-RNO-212356] Formation of CSL-NICD coactivator complex [Reaction:R-RNO-8938231] RUNX1:CBFB binds CREBBP [BlackBoxEvent:R-RNO-1234167] Formation of HIF:CBP:p300 complex at promoters
(hasComponent)	[Complex:R-RNO-9038050] GREB1:ESR1:ESTG:EP300:CREBBP [nucleoplasm] [Complex:R-RNO-9626931] FOXO1:CREBBP [nucleoplasm] [Complex:R-RNO-8864321] TFAP2 homo- and heterodimers:CITED2,CITED4,(CITED1):EP300:CREBBP [nucleoplasm] [Complex:R-RNO-212451] CSL NICD coactivator complex [nucleoplasm] [Complex:R-RNO-8938230] RUNX1:CBFB:CREBBP [nucleoplasm] [Complex:R-RNO-1234099] HIF:CBP:p300 [nucleoplasm] [Complex:R-RNO-1604462] NOTCH1 Coactivator Complex [nucleoplasm]
(regulator)	[NegativeRegulation:10216883] Negative regulation by 'CREBBP [nucleoplasm]'
(physicalEntity)	[CatalystActivity:10216876] protein-lysine-acetyltransferase activity of CREBBP [nucleoplasm]
(hasMember)	[DefinedSet:R-RNO-1027362] CREBBP,EP300 [nucleoplasm] [DefinedSet:R-RNO-400216] Coactivators of PPARalpha [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-193545] CREBBP [nucleoplasm]

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