Reactome | HIF:CBP:p300 [nucleoplasm]

Schema > Complex > Entries

HIF:CBP:p300 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1234143] May, B, 2011-03-18
dbId	1234099
displayName	HIF:CBP:p300 [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-193545] CREBBP [nucleoplasm] [OtherEntity:R-ALL-29428] DNA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm] [Complex:R-HSA-1234130] HIF [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-1234099] HIF:CBP:p300 [nucleoplasm] - Mus musculus [Complex:R-RNO-1234099] HIF:CBP:p300 [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-1234099] HIF:CBP:p300 [nucleoplasm] - Canis familiaris [Complex:R-BTA-1234099] HIF:CBP:p300 [nucleoplasm] - Bos taurus [Complex:R-SSC-1234099] HIF:CBP:p300 [nucleoplasm] - Sus scrofa [Complex:R-GGA-1234099] HIF:CBP:p300 [nucleoplasm] - Gallus gallus [Complex:R-DME-1234099] HIF:CBP:p300 [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-1234099] HIF:CBP:p300 [nucleoplasm] - Caenorhabditis elegans
isChimeric	false
literatureReference	[LiteratureReference:1234051] Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein [LiteratureReference:1233972] Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response [LiteratureReference:1233962] Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300 [LiteratureReference:1233941] Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha [LiteratureReference:1233943] Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine [LiteratureReference:1234022] Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha [LiteratureReference:1235066] Purification and characterization of hypoxia-inducible factor 1
maxDepth	4
modified	[InstanceEdit:9717040] May, Bruce, 2021-03-03
name	HIF:CBP:p300
positivelyRegulates	[PositiveGeneExpressionRegulation:R-HSA-1235080] Positive gene expression regulation by 'HIF:CBP:p300 [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-1235078] Positive gene expression regulation by 'HIF:CBP:p300 [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-1235075] Positive gene expression regulation by 'HIF:CBP:p300 [nucleoplasm]'
producedByEvent	[BlackBoxEvent:R-HSA-1234167] Formation of HIF:CBP:p300 complex at promoters - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1234099
updateTrackers	[UpdateTracker:9902383] Update Tracker - [Complex:1234099] HIF:CBP:p300 [nucleoplasm] - v77:[addLiteratureReference, updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9902383] Update Tracker - [Complex:1234099] HIF:CBP:p300 [nucleoplasm] - v77:[addLiteratureReference, updateContainedComponent]
(regulator)	[PositiveGeneExpressionRegulation:R-HSA-1235080] Positive gene expression regulation by 'HIF:CBP:p300 [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-1235078] Positive gene expression regulation by 'HIF:CBP:p300 [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-1235075] Positive gene expression regulation by 'HIF:CBP:p300 [nucleoplasm]'
(output)	[BlackBoxEvent:R-HSA-1234167] Formation of HIF:CBP:p300 complex at promoters

© 2026 Reactome

Cite Us!