Reactome | p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the PER1 gene

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p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the PER1 gene Show undefined attributes

authored	[InstanceEdit:9923004] May, Bruce, 2024-09-21
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9922979] May, Bruce, 2024-09-29
dbId	9922982
deleted	[Deleted:9938751] Deletion of instance: 5663174
displayName	p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the PER1 gene
edited	[InstanceEdit:9923004] May, Bruce, 2024-09-21
eventOf	[Pathway:R-HSA-9931510] Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9909561] Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-1 (PER1) - Homo sapiens [BlackBoxEvent:R-HSA-9920724] p-T451,T461-CLOCK is phosphorylated on serines-440,441,446 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9926626] p-S97-Bmal1:p-T451,T461-Clock,p-Npas2 binds the Per1 gene - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-193545] CREBBP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1183223] KMT2A [nucleoplasm] 4 × [Complex:R-HSA-9933425] p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5641209] PER1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2 and coactivators bind the PER1 gene
output	[Complex:R-HSA-9933418] p-S90-BMAL1:p-T451,T461-CLOCK,p-NPAS2:CREBBP:KMT2A:PER1 gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9920665] p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9922982
summation	[Summation:9929310] A dimer of the phosphorylated BMAL1:CLOCK heterodimer binds ...

Referrals

(replacementInstances)	[Deleted:9938751] Deletion of instance: 5663174
(precedingEvent)	[BlackBoxEvent:R-HSA-9920724] p-T451,T461-CLOCK is phosphorylated on serines-440,441,446 [BlackBoxEvent:R-HSA-9909561] Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-1 (PER1)
(hasEvent)	[Pathway:R-HSA-9931510] Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
(inferredTo)	[Reaction:R-MMU-9926626] p-S97-Bmal1:p-T451,T461-Clock,p-Npas2 binds the Per1 gene

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