AHCY:NAD+ tetramer hydrolyses AdoHcy

Stable Identifier
R-HSA-174401
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
S-adenoylhomocysteine is hydrolyzed
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Adenosylhomocysteinase (AHCY) is a tetrameric, NAD+-bound, cytosolic protein that regulates all adenosylmethionine-(AdoMet) dependent transmethylations by hydrolysing the feedback inhibitor adenosylhomocysteine (AdoHcy) to homocysteine (HCYS) and adenosine (Ade-Rib) (Turner et al. 1998, Yang et al. 2003).

Literature References
PubMed ID Title Journal Year
12590576 Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions

Borchardt, RT, Kuczera, K, Howell, PL, Turner, MA, Yin, DH, Yang, X, Hu, Y, Schowen, RL, Wang, M

Biochemistry 2003
9586999 Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength

Turner, MA, Hershfield, MS, Howell, PL, Borchardt, RT, Yuan, CS, Smith, GD

Nat. Struct. Biol. 1998
Participants
Participates
Catalyst Activity

adenosylhomocysteinase activity of AHCY:NAD+ tetramer [cytosol]

Orthologous Events
Reviewed
Created
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