Reactome | AHCY:NAD+ tetramer hydrolyses AdoHcy

AHCY:NAD+ tetramer hydrolyses AdoHcy

Stable Identifier

R-HSA-174401

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

S-adenoylhomocysteine is hydrolyzed

ReviewStatus

5/5

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Adenosylhomocysteinase (AHCY) is a tetrameric, NAD+-bound, cytosolic protein that regulates all adenosylmethionine-(AdoMet) dependent transmethylations by hydrolysing the feedback inhibitor adenosylhomocysteine (AdoHcy) to homocysteine (HCYS) and adenosine (Ade-Rib) (Turner et al. 1998, Yang et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12590576	Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions Borchardt, RT, Kuczera, K, Howell, PL, Turner, MA, Yin, DH, Yang, X, Hu, Y, Schowen, RL, Wang, M	Biochemistry	2003
9586999	Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength Turner, MA, Hershfield, MS, Howell, PL, Borchardt, RT, Yuan, CS, Smith, GD	Nat. Struct. Biol.	1998