Reactome | AHCY:NAD+ tetramer hydrolyses AdoHcy

AHCY:NAD+ tetramer hydrolyses AdoHcy

Stable Identifier

R-HSA-174401

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

H2O + S-adenosyl-L-homocysteine => adenosine + L-homocysteine

ReviewStatus

5/5

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Adenosylhomocysteinase (AHCY) is a tetrameric, NAD+-bound, cytosolic protein that regulates all adenosylmethionine-(AdoMet) dependent transmethylations by hydrolysing the feedback inhibitor adenosylhomocysteine (AdoHcy) to homocysteine (HCYS) and adenosine (Ade-Rib) (Turner et al. 1998, Yang et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12590576	Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions Yang, X, Hu, Y, Yin, DH, Turner, MA, Wang, M, Borchardt, RT, Howell, PL, Kuczera, K, Schowen, RL	Biochemistry	2003
9586999	Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength Turner, MA, Yuan, CS, Borchardt, RT, Hershfield, MS, Smith, GD, Howell, PL	Nat. Struct. Biol.	1998