AHCY:NAD+ tetramer hydrolyses AdoHcy

Stable Identifier
R-HSA-174401
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
S-adenoylhomocysteine is hydrolyzed
Locations in the PathwayBrowser
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Adenosylhomocysteinase (AHCY) is a tetrameric, NAD+-bound, cytosolic protein that regulates all adenosylmethionine-(AdoMet) dependent transmethylations by hydrolysing the feedback inhibitor adenosylhomocysteine (AdoHcy) to homocysteine (HCYS) and adenosine (Ade-Rib) (Turner et al. 1998, Yang et al. 2003).

Literature References
PubMed ID Title Journal Year
9586999 Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength

Turner, MA, Yuan, CS, Borchardt, RT, Hershfield, MS, Smith, GD, Howell, PL

Nat. Struct. Biol. 1998
12590576 Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions

Yang, X, Hu, Y, Yin, DH, Turner, MA, Wang, M, Borchardt, RT, Howell, PL, Kuczera, K, Schowen, RL

Biochemistry 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
adenosylhomocysteinase activity of AHCY:NAD+ tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed
Created