Reactome | AHCY:NAD+ tetramer hydrolyses AdoHcy

AHCY:NAD+ tetramer hydrolyses AdoHcy

Stable Identifier

R-HSA-174401

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

S-adenoylhomocysteine is hydrolyzed

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Adenosylhomocysteinase (AHCY) is a tetrameric, NAD+-bound, cytosolic protein that regulates all adenosylmethionine-(AdoMet) dependent transmethylations by hydrolysing the feedback inhibitor adenosylhomocysteine (AdoHcy) to homocysteine (HCYS) and adenosine (Ade-Rib) (Turner et al. 1998, Yang et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
9586999	Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength Turner, MA, Yuan, CS, Borchardt, RT, Hershfield, MS, Smith, GD, Howell, PL	Nat. Struct. Biol.	1998
12590576	Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions Yang, X, Hu, Y, Yin, DH, Turner, MA, Wang, M, Borchardt, RT, Howell, PL, Kuczera, K, Schowen, RL	Biochemistry	2003