Adenosylhomocysteinase (AHCY) is a tetrameric, NAD+-bound, cytosolic protein that regulates all adenosylmethionine-(AdoMet) dependent transmethylations by hydrolysing the feedback inhibitor adenosylhomocysteine (AdoHcy) to homocysteine (HCYS) and adenosine (Ade-Rib) (Turner et al. 1998, Yang et al. 2003).
Borchardt, RT, Kuczera, K, Howell, PL, Turner, MA, Yin, DH, Yang, X, Hu, Y, Schowen, RL, Wang, M
Turner, MA, Hershfield, MS, Howell, PL, Borchardt, RT, Yuan, CS, Smith, GD
adenosylhomocysteinase activity of AHCY:NAD+ tetramer [cytosol]
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