Reactome | MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met

Schema > Reaction > Entries

MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met Show undefined attributes

authored	[InstanceEdit:5603083] Jassal, Bijay, 2014-06-27
catalystActivity	[CatalystActivity:5603117] methionine adenosyltransferase activity of MAT2B:MAT2A:K+:2Mg2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5603083] Jassal, Bijay, 2014-06-27
crossReference	[DatabaseIdentifier:12667634] RHEA:21081
dbId	5603114
displayName	MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met
edited	[InstanceEdit:5603083] Jassal, Bijay, 2014-06-27
eventOf	[Pathway:R-HSA-156581] Methylation - Homo sapiens
followingEvent	[Reaction:R-HSA-175976] TMT transfers CH3 from AdoMet to BME - Homo sapiens [Reaction:R-HSA-175987] NNMT transfers CH3 from AdoMet to PY - Homo sapiens [Reaction:R-HSA-175983] COMT transfer CH3 from AdoMet to 3,4DHBNZ - Homo sapiens [Reaction:R-HSA-158609] TPMT transfers CH3 from AdoMet to 6MP - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-174390] L-Met [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5603111] Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II) [LiteratureReference:5603123] Expression and functional interaction of the catalytic and regulatory subunits of human methionine adenosyltransferase in mammalian cells
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met AdoMet is sythesized from methionine's reaction with ATP
orthologousEvent	[Reaction:R-RNO-5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met - Rattus norvegicus [Reaction:R-DDI-5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met - Dictyostelium discoideum [Reaction:R-GGA-5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met - Gallus gallus [Reaction:R-XTR-5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met - Xenopus tropicalis [Reaction:R-DRE-5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met - Danio rerio [Reaction:R-SSC-5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met - Sus scrofa [Reaction:R-CFA-5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met - Canis familiaris [Reaction:R-MMU-5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met - Mus musculus
output	[SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:377465] D'Eustachio, P, 2008-06-12 14:43:38
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5603114
summation	[Summation:5603121] S-adenosylmethionine (AdoMet, SAM) is an essential metabolit...

Referrals

(hasEvent)	[Pathway:R-HSA-156581] Methylation
(precedingEvent)	[Reaction:R-HSA-175976] TMT transfers CH3 from AdoMet to BME [Reaction:R-HSA-175987] NNMT transfers CH3 from AdoMet to PY [Reaction:R-HSA-158609] TPMT transfers CH3 from AdoMet to 6MP [Reaction:R-HSA-175983] COMT transfer CH3 from AdoMet to 3,4DHBNZ