Reactome | CYP1A2 S-demethylates 6MMP

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CYP1A2 S-demethylates 6MMP Show undefined attributes

catalystActivity	[CatalystActivity:76372] monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17960] smooth endoplasmic reticulum
created	[InstanceEdit:76326] Jassal, B, 2003-08-05 00:00:00
dbId	76386
displayName	CYP1A2 S-demethylates 6MMP
eventOf	[Pathway:R-HSA-156581] Methylation - Homo sapiens
followingEvent	[Reaction:R-HSA-158609] TPMT transfers CH3 from AdoMet to 6MP - Homo sapiens
input	[SimpleEntity:R-ALL-76384] 6MMP [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[Book:76380] 9780071470513 Parkinson, A Casarett and Doull's Toxicology 5th Edn
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	CYP1A2 S-demethylates 6MMP S-atom dealkylation of 6-methylmercaptopurine
orthologousEvent	[Reaction:R-BTA-76386] CYP1A2 S-demethylates 6MMP - Bos taurus [Reaction:R-DRE-76386] CYP1A2 S-demethylates 6MMP - Danio rerio [Reaction:R-SSC-76386] CYP1A2 S-demethylates 6MMP - Sus scrofa [Reaction:R-RNO-76386] CYP1A2 S-demethylates 6MMP - Rattus norvegicus [Reaction:R-MMU-76386] CYP1A2 S-demethylates 6MMP - Mus musculus
output	[SimpleEntity:R-ALL-33153] 6MP [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-143501] CH2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen]
releaseDate	2005-02-01
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-76386
summation	[Summation:178352] At the beginning of this reaction, 1 molecule of 'H+', 1 mol...

Referrals

(hasEvent)	[Pathway:R-HSA-156581] Methylation
(precedingEvent)	[Reaction:R-HSA-158609] TPMT transfers CH3 from AdoMet to 6MP

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