Reactome | Phase II - Conjugation of compounds

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Phase II - Conjugation of compounds Show undefined attributes

authored	[InstanceEdit:156583] Jassal, B, 2004-11-29 11:42:34
created	[InstanceEdit:156583] Jassal, B, 2004-11-29 11:42:34
dbId	156580
diseasePathways	[Pathway:R-HSA-5579024] Defective MAT1A causes MATD - Homo sapiens [Pathway:R-HSA-5579020] Defective SLC35D1 causes SCHBCKD - Homo sapiens [Pathway:R-HSA-5579022] Defective GGT1 causes GLUTH - Homo sapiens [Pathway:R-HSA-5578997] Defective AHCY causes HMAHCHD - Homo sapiens [Pathway:R-HSA-5578999] Defective GCLC causes HAGGSD - Homo sapiens [Pathway:R-HSA-5578998] Defective OPLAH causes OPLAHD - Homo sapiens [Pathway:R-HSA-5578995] Defective TPMT causes TPMT deficiency - Homo sapiens [Pathway:R-HSA-5579006] Defective GSS causes GSS deficiency - Homo sapiens
displayName	Phase II - Conjugation of compounds
doi	10.3180/REACT_6959.3
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf	[Pathway:R-HSA-211859] Biological oxidations - Homo sapiens
figure	[Figure:158020] /figures/Phase2_cofactors.jpg
goBiologicalProcess	[GO_BiologicalProcess:8764] xenobiotic metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-156588] Glucuronidation - Homo sapiens [Pathway:R-HSA-156584] Cytosolic sulfonation of small molecules - Homo sapiens [Pathway:R-HSA-156582] Acetylation - Homo sapiens [Pathway:R-HSA-156581] Methylation - Homo sapiens [Pathway:R-HSA-156590] Glutathione conjugation - Homo sapiens [Pathway:R-HSA-156587] Amino Acid conjugation - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[Book:76380] 9780071470513 Parkinson, A Casarett and Doull's Toxicology 5th Edn [LiteratureReference:266229] The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms
maxDepth	5
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Phase II - Conjugation of compounds
orthologousEvent	[Pathway:R-MMU-156580] Phase II - Conjugation of compounds - Mus musculus [Pathway:R-RNO-156580] Phase II - Conjugation of compounds - Rattus norvegicus [Pathway:R-CFA-156580] Phase II - Conjugation of compounds - Canis familiaris [Pathway:R-BTA-156580] Phase II - Conjugation of compounds - Bos taurus [Pathway:R-SSC-156580] Phase II - Conjugation of compounds - Sus scrofa [Pathway:R-DRE-156580] Phase II - Conjugation of compounds - Danio rerio [Pathway:R-XTR-156580] Phase II - Conjugation of compounds - Xenopus tropicalis [Pathway:R-GGA-156580] Phase II - Conjugation of compounds - Gallus gallus [Pathway:R-DME-156580] Phase II - Conjugation of compounds - Drosophila melanogaster [Pathway:R-CEL-156580] Phase II - Conjugation of compounds - Caenorhabditis elegans [Pathway:R-DDI-156580] Phase II - Conjugation of compounds - Dictyostelium discoideum [Pathway:R-SPO-156580] Phase II - Conjugation of compounds - Schizosaccharomyces pombe [Pathway:R-SCE-156580] Phase II - Conjugation of compounds - Saccharomyces cerevisiae [Pathway:R-PFA-156580] Phase II - Conjugation of compounds - Plasmodium falciparum
releaseDate	2008-06-30
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-156580
summation	[Summation:156589] Phase II of biotransformation is concerned with *conjug...*
updateTrackers	[UpdateTracker:9775691] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v78:[updateIndirectRLE] [UpdateTracker:9842256] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v86:[updateIndirectRLE] [UpdateTracker:9789851] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v37:[updateContainedPathway] [UpdateTracker:9786125] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v50:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782076] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v59:[updateContainedPathway] [UpdateTracker:9784487] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v54:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789158] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v38:[updateContainedPathway] [UpdateTracker:9791866] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v25:[addLiteratureReference, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9792139] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v23:[updateIndirectRLE] [UpdateTracker:9774939] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v80:[updateIndirectRLE] [UpdateTracker:9787481] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v45:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9778153] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v68:[updateContainedPathway] [UpdateTracker:9790596] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v33:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9787830] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v44:[updateIndirectRLE] [UpdateTracker:9776543] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v75:[updateIndirectRLE] [UpdateTracker:9788805] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v40:[updateIndirectRLE] [UpdateTracker:9781763] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v60:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9787216] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v46:[updateIndirectRLE] [UpdateTracker:9780978] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v61:[updateIndirectRLE] [UpdateTracker:9792207] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v22:[updateIndirectRLE] [UpdateTracker:9792031] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v24:[updateContainedPathway] [UpdateTracker:9786624] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v49:[updateIndirectRLE] [UpdateTracker:9785806] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v51:[updateIndirectRLE] [UpdateTracker:9783751] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v56:[updateContainedPathway] [UpdateTracker:9784014] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v55:[updateContainedPathway]

Referrals

(hasEvent)	[Pathway:R-HSA-211859] Biological oxidations
(hasEncapsulatedEvent)	[Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes [Pathway:R-HSA-9749641] Aspirin ADME [Pathway:R-HSA-5362517] Signaling by Retinoic Acid
(normalPathway)	[Pathway:R-HSA-5579024] Defective MAT1A causes MATD [Pathway:R-HSA-5579020] Defective SLC35D1 causes SCHBCKD [Pathway:R-HSA-5579022] Defective GGT1 causes GLUTH [Pathway:R-HSA-5578997] Defective AHCY causes HMAHCHD [Pathway:R-HSA-5578999] Defective GCLC causes HAGGSD [Pathway:R-HSA-5578998] Defective OPLAH causes OPLAHD [Pathway:R-HSA-5578995] Defective TPMT causes TPMT deficiency [Pathway:R-HSA-5579006] Defective GSS causes GSS deficiency
(updatedInstance)	[UpdateTracker:9775691] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v78:[updateIndirectRLE] [UpdateTracker:9842256] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v86:[updateIndirectRLE] [UpdateTracker:9789851] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v37:[updateContainedPathway] [UpdateTracker:9786125] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v50:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782076] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v59:[updateContainedPathway] [UpdateTracker:9784487] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v54:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789158] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v38:[updateContainedPathway] [UpdateTracker:9791866] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v25:[addLiteratureReference, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9792139] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v23:[updateIndirectRLE] [UpdateTracker:9774939] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v80:[updateIndirectRLE] [UpdateTracker:9787481] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v45:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9778153] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v68:[updateContainedPathway] [UpdateTracker:9790596] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v33:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9787830] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v44:[updateIndirectRLE] [UpdateTracker:9776543] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v75:[updateIndirectRLE] [UpdateTracker:9788805] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v40:[updateIndirectRLE] [UpdateTracker:9781763] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v60:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9787216] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v46:[updateIndirectRLE] [UpdateTracker:9780978] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v61:[updateIndirectRLE] [UpdateTracker:9792207] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v22:[updateIndirectRLE] [UpdateTracker:9792031] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v24:[updateContainedPathway] [UpdateTracker:9786624] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v49:[updateIndirectRLE] [UpdateTracker:9785806] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v51:[updateIndirectRLE] [UpdateTracker:9783751] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v56:[updateContainedPathway] [UpdateTracker:9784014] Update Tracker - [Pathway:156580] Phase II - Conjugation of compounds - v55:[updateContainedPathway]

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