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Schema
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Entries
ISG15 antiviral mechanism
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authored
[InstanceEdit:1169393] Garapati, P V, 2011-01-18
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:1169409] Garapati, P V, 2011-01-18
crossReference
[DatabaseIdentifier:12325564] BioModels Database:BIOMD0000000575
dbId
1169408
displayName
ISG15 antiviral mechanism
edited
[InstanceEdit:1169393] Garapati, P V, 2011-01-18
eventOf
[Pathway:R-HSA-1169410] Antiviral mechanism by IFN-stimulated genes - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-1169399] Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding - Homo sapiens
[Reaction:R-HSA-1169397] Activation of ISG15 by UBA7 E1 ligase - Homo sapiens
[Reaction:R-HSA-1169404] Transfer of ISG15 from E1 to E2 (UBCH8) - Homo sapiens
[Reaction:R-HSA-1169403] Interaction of E3 ligase with ISG15:E2 complex - Homo sapiens
[Reaction:R-HSA-1678843] ISGylation of protein translation regulator 4EHP - Homo sapiens
[Reaction:R-HSA-1678842] Competitive inhibition of translation initiation by ISGylated 4EHP - Homo sapiens
[Reaction:R-HSA-1169405] ISGylation of protein phosphatase 1 beta (PP2CB) - Homo sapiens
[Reaction:R-HSA-1169398] ISGylation of host protein filamin B - Homo sapiens
[Reaction:R-HSA-1169402] ISGylation of E2 conjugating enzymes - Homo sapiens
[Reaction:R-HSA-1169406] ISGylation of host proteins - Homo sapiens
[Reaction:R-HSA-1169394] ISGylation of IRF3 - Homo sapiens
[BlackBoxEvent:R-HSA-936462] PIN1 mediated IRF3 degradation - Homo sapiens
[Reaction:R-HSA-1169395] ISGylation of viral protein NS1 - Homo sapiens
[BlackBoxEvent:R-HSA-1176059] Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus - Homo sapiens
[BlackBoxEvent:R-HSA-1169307] Monoubiquitination of N-myristoyl GAG (P12493) protein - Homo sapiens
[BlackBoxEvent:R-HSA-1678841] Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1169301] ISG15 and immune diseases
[URL:1169304] http://www.mdpi.com/1999-4915/2/10/2154/
[LiteratureReference:1169277] Emerging role of ISG15 in antiviral immunity
[LiteratureReference:1169329] High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction
[LiteratureReference:1015669] Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways
[LiteratureReference:1295505] ISG15: a ubiquitin-like enigma
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
ISG15 antiviral mechanism
orthologousEvent
[Pathway:R-PFA-1169408] ISG15 antiviral mechanism - Plasmodium falciparum
[Pathway:R-MMU-1169408] ISG15 antiviral mechanism - Mus musculus
[Pathway:R-CEL-1169408] ISG15 antiviral mechanism - Caenorhabditis elegans
[Pathway:R-DDI-1169408] ISG15 antiviral mechanism - Dictyostelium discoideum
[Pathway:R-DME-1169408] ISG15 antiviral mechanism - Drosophila melanogaster
[Pathway:R-DRE-1169408] ISG15 antiviral mechanism - Danio rerio
[Pathway:R-GGA-1169408] ISG15 antiviral mechanism - Gallus gallus
[Pathway:R-XTR-1169408] ISG15 antiviral mechanism - Xenopus tropicalis
[Pathway:R-SSC-1169408] ISG15 antiviral mechanism - Sus scrofa
[Pathway:R-BTA-1169408] ISG15 antiviral mechanism - Bos taurus
[Pathway:R-CFA-1169408] ISG15 antiviral mechanism - Canis familiaris
[Pathway:R-RNO-1169408] ISG15 antiviral mechanism - Rattus norvegicus
releaseDate
2011-12-06
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1213478] Zhang, DE, 2011-02-10
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-1169408
summation
[Summation:1169280] Interferon-stimulated gene 15 (ISG15) is a member of the ubi...
Referrals
(hasEvent)
[Pathway:R-HSA-1169410] Antiviral mechanism by IFN-stimulated genes
(hasEncapsulatedEvent)
[Pathway:R-HSA-9833110] RSV-host interactions
[Pathway:R-HSA-9833482] PKR-mediated signaling
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