Reactome | ISG15 antiviral mechanism

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ISG15 antiviral mechanism Show undefined attributes

authored	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1169409] Garapati, P V, 2011-01-18
dbId	1169408
displayName	ISG15 antiviral mechanism
edited	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
eventOf	[Pathway:R-HSA-1169410] Antimicrobial mechanism of IFN-stimulated genes - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-1169399] Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding - Homo sapiens [Reaction:R-HSA-1169397] Activation of ISG15 by UBA7 E1 enzyme - Homo sapiens [Reaction:R-HSA-1169404] Transfer of ISG15 from E1 to E2 (UBCH8) - Homo sapiens [Reaction:R-HSA-1169403] Interaction of E3 ligase with ISG15:E2 complex - Homo sapiens [Reaction:R-HSA-1678843] ISGylation of protein translation regulator 4EHP - Homo sapiens [Reaction:R-HSA-1678842] Competitive inhibition of translation initiation by ISGylated 4EHP - Homo sapiens [Reaction:R-HSA-1169405] ISGylation of protein phosphatase 1 beta (PP2CB) - Homo sapiens [Reaction:R-HSA-1169398] ISGylation of host protein filamin B - Homo sapiens [Reaction:R-HSA-1169402] ISGylation of E2 conjugating enzymes - Homo sapiens [Reaction:R-HSA-1169406] ISGylation of host proteins - Homo sapiens [Reaction:R-HSA-1169394] ISGylation of IRF3 - Homo sapiens [BlackBoxEvent:R-HSA-936462] PIN1 mediated IRF3 degradation - Homo sapiens [Reaction:R-HSA-1169395] ISGylation of viral protein NS1 - Homo sapiens [BlackBoxEvent:R-HSA-1176059] Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus - Homo sapiens [BlackBoxEvent:R-HSA-1169307] Monoubiquitination of N-myristoyl GAG (P12493) protein - Homo sapiens [BlackBoxEvent:R-HSA-1678841] Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:1169301] ISG15 and immune diseases [URL:1169304] http://www.mdpi.com/1999-4915/2/10/2154/ [LiteratureReference:1169277] Emerging role of ISG15 in antiviral immunity [LiteratureReference:1169329] High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction [LiteratureReference:1015669] Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways [LiteratureReference:1295505] ISG15: a ubiquitin-like enigma
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ISG15 antiviral mechanism
orthologousEvent	[Pathway:R-MMU-1169408] ISG15 antiviral mechanism - Mus musculus [Pathway:R-RNO-1169408] ISG15 antiviral mechanism - Rattus norvegicus [Pathway:R-DDI-1169408] ISG15 antiviral mechanism - Dictyostelium discoideum [Pathway:R-CEL-1169408] ISG15 antiviral mechanism - Caenorhabditis elegans [Pathway:R-SSC-1169408] ISG15 antiviral mechanism - Sus scrofa [Pathway:R-BTA-1169408] ISG15 antiviral mechanism - Bos taurus [Pathway:R-CFA-1169408] ISG15 antiviral mechanism - Canis familiaris
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213478] Zhang, DE, 2011-02-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1169408
summation	[Summation:1169280] Interferon-stimulated gene 15 (ISG15) is a member of the ubi...
updateTrackers	[UpdateTracker:9784208] Update Tracker - [Pathway:1169408] ISG15 antiviral mechanism - v54:[updateContainedRLE] [UpdateTracker:9776200] Update Tracker - [Pathway:1169408] ISG15 antiviral mechanism - v77:[updateContainedRLE] [UpdateTracker:9775810] Update Tracker - [Pathway:1169408] ISG15 antiviral mechanism - v78:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9784208] Update Tracker - [Pathway:1169408] ISG15 antiviral mechanism - v54:[updateContainedRLE] [UpdateTracker:9776200] Update Tracker - [Pathway:1169408] ISG15 antiviral mechanism - v77:[updateContainedRLE] [UpdateTracker:9775810] Update Tracker - [Pathway:1169408] ISG15 antiviral mechanism - v78:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-1169410] Antimicrobial mechanism of IFN-stimulated genes
(hasEncapsulatedEvent)	[Pathway:R-HSA-9920588] Dengue virus activates/modulates innate and adaptive immune responses [Pathway:R-HSA-9833110] RSV-host interactions [Pathway:R-HSA-9833482] PKR-mediated signaling

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