Reactome | ISGylation of IRF3

Schema > Reaction > Entries

ISGylation of IRF3 Show undefined attributes

authored	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
catalystActivity	[CatalystActivity:1169401] ubiquitin-protein transferase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
dbId	1169394
displayName	ISGylation of IRF3
edited	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
eventOf	[Pathway:R-HSA-1169408] ISG15 antiviral mechanism - Homo sapiens
followingEvent	[Reaction:R-HSA-9729725] SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-166251] IRF3 [cytosol] [Complex:R-HSA-1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1169318] Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification [LiteratureReference:1169352] ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation
modified	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
name	ISGylation of IRF3
orthologousEvent	[Reaction:R-SSC-1169394] ISGylation of IRF3 - Sus scrofa [Reaction:R-BTA-1169394] ISGylation of IRF3 - Bos taurus [Reaction:R-RNO-1169394] ISGylation of IRF3 - Rattus norvegicus [Reaction:R-MMU-1169394] ISGylation of IRF3 - Mus musculus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [CandidateSet:R-HSA-1169381] ISG15 E3 ligases [cytosol] [Complex:R-HSA-1169389] ISGylated IRF3 [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol] [EntityWithAccessionedSequence:R-HSA-936014] UBE2L6 [cytosol]
precedingEvent	[Reaction:R-HSA-1169403] Interaction of E3 ligase with ISG15:E2 complex - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213478] Zhang, DE, 2011-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1169394
summation	[Summation:1169298] The transcription factor IRF3 is a target for ISGylation. Co...

Referrals

(hasEvent)	[Pathway:R-HSA-1169408] ISG15 antiviral mechanism
(precedingEvent)	[Reaction:R-HSA-9729725] SARS-CoV-2 nsp3 deISGylates ISGylated IRF3