Reactome | ISGylation of host proteins

Schema > Reaction > Entries

ISGylation of host proteins Show undefined attributes

authored	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
catalystActivity	[CatalystActivity:1169401] ISG15 ligase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
dbId	1169406
displayName	ISGylation of host proteins
edited	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
eventOf	[Pathway:R-HSA-1169408] ISG15 antiviral mechanism - Homo sapiens
input	[CandidateSet:R-HSA-1169379] ISG15 targets [cytosol] [Complex:R-HSA-1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1169329] High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction [LiteratureReference:1015669] Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways [LiteratureReference:1169373] Proteomic identification of proteins conjugated to ISG15 in mouse and human cells
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ISGylation of host proteins
orthologousEvent	[Reaction:R-DDI-1169406] ISGylation of host proteins - Dictyostelium discoideum [Reaction:R-CEL-1169406] ISGylation of host proteins - Caenorhabditis elegans [Reaction:R-SSC-1169406] ISGylation of host proteins - Sus scrofa [Reaction:R-BTA-1169406] ISGylation of host proteins - Bos taurus [Reaction:R-RNO-1169406] ISGylation of host proteins - Rattus norvegicus [Reaction:R-MMU-1169406] ISGylation of host proteins - Mus musculus
output	[CandidateSet:R-HSA-1169381] ISG15 E3 ligases [cytosol] [Complex:R-HSA-1169387] ISGylated host proteins [cytosol] [EntityWithAccessionedSequence:R-HSA-936014] UBE2L6 [cytosol]
precedingEvent	[Reaction:R-HSA-1169403] Interaction of E3 ligase with ISG15:E2 complex - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213478] Zhang, DE, 2011-02-10 [InstanceEdit:9969059] D'Eustachio, Peter, 2025-10-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1169406
summation	[Summation:1169295] Many host proteins are targets for ISGylation including cons...
updateTrackers	[UpdateTracker:9971879] Update Tracker - [Reaction:1169406] ISGylation of host proteins - v95:[addInput, addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9971879] Update Tracker - [Reaction:1169406] ISGylation of host proteins - v95:[addInput, addOutput]
(hasEvent)	[Pathway:R-HSA-1169408] ISG15 antiviral mechanism