Reactome | Interaction of E3 ligase with ISG15:E2 complex

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Interaction of E3 ligase with ISG15:E2 complex Show undefined attributes

authored	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
dbId	1169403
displayName	Interaction of E3 ligase with ISG15:E2 complex
edited	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
eventOf	[Pathway:R-HSA-1169408] ISG15 antiviral mechanism - Homo sapiens
followingEvent	[Reaction:R-HSA-1169406] ISGylation of host proteins - Homo sapiens [Reaction:R-HSA-1169405] ISGylation of protein phosphatase 1 beta (PP2CB) - Homo sapiens [Reaction:R-HSA-1169402] ISGylation of E2 conjugating enzymes - Homo sapiens [Reaction:R-HSA-1169398] ISGylation of host protein filamin B - Homo sapiens [Reaction:R-HSA-1169395] ISGylation of viral protein NS1 - Homo sapiens [BlackBoxEvent:R-HSA-9833973] ISGylation of PKR - Homo sapiens [Reaction:R-HSA-1169394] ISGylation of IRF3 - Homo sapiens
input	[CandidateSet:R-HSA-1169381] ISG15 E3 ligases [cytosol] [Complex:R-HSA-1169385] ISG15:UBCH8 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1169355] Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells [LiteratureReference:1169356] HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets [LiteratureReference:1678807] ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP [LiteratureReference:1169324] The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Interaction of E3 ligase with ISG15:E2 complex
orthologousEvent	[Reaction:R-DDI-1169403] Interaction of E3 ligase with ISG15:E2 complex - Dictyostelium discoideum [Reaction:R-CEL-1169403] Interaction of E3 ligase with ISG15:E2 complex - Caenorhabditis elegans [Reaction:R-SSC-1169403] Interaction of E3 ligase with ISG15:E2 complex - Sus scrofa [Reaction:R-BTA-1169403] Interaction of E3 ligase with ISG15:E2 complex - Bos taurus [Reaction:R-RNO-1169403] Interaction of E3 ligase with ISG15:E2 complex - Rattus norvegicus [Reaction:R-MMU-1169403] Interaction of E3 ligase with ISG15:E2 complex - Mus musculus
output	[Complex:R-HSA-1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol]
precedingEvent	[Reaction:R-HSA-1169404] Transfer of ISG15 from E1 to E2 (UBCH8) - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213478] Zhang, DE, 2011-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1169403
summation	[Summation:1169286] Ubiquitin ligase HERC5/CEB1 appears to be the predominant E3...

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[Pathway:R-HSA-1169408] ISG15 antiviral mechanism

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