Reactome | PIN1 mediated IRF3 degradation

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PIN1 mediated IRF3 degradation Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
catalystActivity	[CatalystActivity:936422] ubiquitin protein ligase activity of unknown ligase [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:936409] Garapati, P V, 2010-08-22
dbId	936462
displayName	PIN1 mediated IRF3 degradation
edited	[InstanceEdit:936409] Garapati, P V, 2010-08-22
eventOf	[Pathway:R-HSA-936440] Negative regulators of DDX58/IFIH1 signaling - Homo sapiens [Pathway:R-HSA-1169408] ISG15 antiviral mechanism - Homo sapiens
input	[Complex:R-HSA-936444] p-IRF3 dimer:PIN1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:936398] Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1 [LiteratureReference:936393] Pin-ning down immune responses to RNA viruses [LiteratureReference:936448] Inhibition of IRF3-dependent antiviral responses by cellular and viral proteins
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PIN1 mediated IRF3 degradation
output	[EntityWithAccessionedSequence:R-HSA-936016] PIN1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-936380] Interaction of PIN1 with p-IRF3 - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-1176076] Negative regulation by 'ISGylated IRF3 [cytosol]'
regulationReference	[RegulationReference:9642369] Negative regulation by 'ISGylated IRF3 [cytosol]' ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-936462
summation	[Summation:936443] PIN1 acts as a negative regulator of IFN induction. Its asso... [Summation:1169298] The transcription factor IRF3 is a target for ISGylation. Co...
updateTrackers	[UpdateTracker:9776048] Update Tracker - [BlackBoxEvent:936462] PIN1 mediated IRF3 degradation - v78:[addSummation] [UpdateTracker:9788930] Update Tracker - [BlackBoxEvent:936462] PIN1 mediated IRF3 degradation - v39:[modifyText] [UpdateTracker:9789932] Update Tracker - [BlackBoxEvent:936462] PIN1 mediated IRF3 degradation - v36:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9776048] Update Tracker - [BlackBoxEvent:936462] PIN1 mediated IRF3 degradation - v78:[addSummation] [UpdateTracker:9788930] Update Tracker - [BlackBoxEvent:936462] PIN1 mediated IRF3 degradation - v39:[modifyText] [UpdateTracker:9789932] Update Tracker - [BlackBoxEvent:936462] PIN1 mediated IRF3 degradation - v36:[addRegulator]
(hasEvent)	[Pathway:R-HSA-1169408] ISG15 antiviral mechanism [Pathway:R-HSA-936440] Negative regulators of DDX58/IFIH1 signaling