Reactome | ISGylation of viral protein NS1

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ISGylation of viral protein NS1 Show undefined attributes

authored	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
catalystActivity	[CatalystActivity:1169401] ISG15 ligase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
dbId	1169395
displayName	ISGylation of viral protein NS1
edited	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
eventOf	[Pathway:R-HSA-1169408] ISG15 antiviral mechanism - Homo sapiens
input	[Complex:R-HSA-1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol] [Complex:R-FLU-169143] NS1 dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1169371] Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein [LiteratureReference:1169622] ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells [LiteratureReference:1169623] Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein
maxDepth	1
modified	[InstanceEdit:9969060] D'Eustachio, Peter, 2025-10-21
name	ISGylation of viral protein NS1
output	[CandidateSet:R-HSA-1169381] ISG15 E3 ligases [cytosol] [Complex:R-HSA-1169392] ISGylated NS1 [cytosol] [EntityWithAccessionedSequence:R-HSA-936014] UBE2L6 [cytosol]
precedingEvent	[Reaction:R-HSA-1169403] Interaction of E3 ligase with ISG15:E2 complex - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
relatedSpecies	[Species:9031716] Influenza A virus
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213478] Zhang, DE, 2011-02-10 [InstanceEdit:9969059] D'Eustachio, Peter, 2025-10-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1169395
summation	[Summation:1169289] Some viral proteins are also targeted for ISGylation. The we...
updateTrackers	[UpdateTracker:9784085] Update Tracker - [Reaction:1169395] ISGylation of viral protein NS1 - v54:[add_removeInput] [UpdateTracker:9971839] Update Tracker - [Reaction:1169395] ISGylation of viral protein NS1 - v95:[addInput, addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9784085] Update Tracker - [Reaction:1169395] ISGylation of viral protein NS1 - v54:[add_removeInput] [UpdateTracker:9971839] Update Tracker - [Reaction:1169395] ISGylation of viral protein NS1 - v95:[addInput, addOutput]
(hasEvent)	[Pathway:R-HSA-1169408] ISG15 antiviral mechanism

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