Reactome | Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus

Schema > BlackBoxEvent > Entries

Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus Show undefined attributes

authored	[InstanceEdit:5146782] Gillespie, ME, 2013-11-18
catalystActivity	[CatalystActivity:450099] structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope]
catalystActivityReference	[CatalystActivityReference:9643944] structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope] Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:1176069] Garapati, P V, 2011-01-25
crossReference	[DatabaseIdentifier:12020763] Mondo:0005812
dbId	1176059
disease	[Disease:1660558] influenza
displayName	Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
edited	[InstanceEdit:5146790] Gillespie, ME, 2013-11-18
eventOf	[Pathway:R-HSA-168276] NS1 Mediated Effects on Host Pathways - Homo sapiens [Pathway:R-HSA-1169408] ISG15 antiviral mechanism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2454643] intracellular transport of virus
input	[DefinedSet:R-HSA-1176060] Importin [cytosol] [Complex:R-FLU-169143] NS1 dimer [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:169570] Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import [LiteratureReference:169539] An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ribonucleoprotein [LiteratureReference:1176064] Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
output	[Complex:R-HSA-1176067] NS1 homodimer:Importin [nucleoplasm]
regulatedBy	[NegativeRegulation:R-HSA-1176075] Negative regulation by 'ISGylated NS1 [cytosol]'
regulationReference	[RegulationReference:9641704] Negative regulation by 'ISGylated NS1 [cytosol]' ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells
relatedSpecies	[Species:9031716] Influenza A virus
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:170177] Gale M, Jr, 2004-05-12 19:00:00
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1176059
summation	[Summation:1181027] Influenza A virus nonstructural protein 1 (NS1A) is a multif...

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