Reactome | ISGylation of E2 conjugating enzymes

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ISGylation of E2 conjugating enzymes Show undefined attributes

authored	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
catalystActivity	[CatalystActivity:1169401] ISG15 ligase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
dbId	1169402
displayName	ISGylation of E2 conjugating enzymes
edited	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
eventOf	[Pathway:R-HSA-1169408] ISG15 antiviral mechanism - Homo sapiens
input	[DefinedSet:R-HSA-1169378] E2 congugating enzymes [cytosol] [Complex:R-HSA-1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1169342] ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity [LiteratureReference:1169333] ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin [LiteratureReference:1169335] Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ISGylation of E2 conjugating enzymes
orthologousEvent	[Reaction:R-DDI-1169402] ISGylation of E2 conjugating enzymes - Dictyostelium discoideum [Reaction:R-CEL-1169402] ISGylation of E2 conjugating enzymes - Caenorhabditis elegans [Reaction:R-SSC-1169402] ISGylation of E2 conjugating enzymes - Sus scrofa [Reaction:R-BTA-1169402] ISGylation of E2 conjugating enzymes - Bos taurus [Reaction:R-RNO-1169402] ISGylation of E2 conjugating enzymes - Rattus norvegicus [Reaction:R-MMU-1169402] ISGylation of E2 conjugating enzymes - Mus musculus
output	[CandidateSet:R-HSA-1169381] ISG15 E3 ligases [cytosol] [Complex:R-HSA-1169382] ISGylated E2 conjugating enzymes [cytosol] [EntityWithAccessionedSequence:R-HSA-936014] UBE2L6 [cytosol]
precedingEvent	[Reaction:R-HSA-1169403] Interaction of E3 ligase with ISG15:E2 complex - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213478] Zhang, DE, 2011-02-10 [InstanceEdit:9969059] D'Eustachio, Peter, 2025-10-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1169402
summation	[Summation:1169296] Ubiquitin conjugating E2 enzymes UBC13 and UBCH6 are targets...
updateTrackers	[UpdateTracker:9971945] Update Tracker - [Reaction:1169402] ISGylation of E2 conjugating enzymes - v95:[addInput, addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9971945] Update Tracker - [Reaction:1169402] ISGylation of E2 conjugating enzymes - v95:[addInput, addOutput]
(hasEvent)	[Pathway:R-HSA-1169408] ISG15 antiviral mechanism