Reactome | Transfer of ISG15 from E1 to E2 (UBCH8)

Schema > Reaction > Entries

Transfer of ISG15 from E1 to E2 (UBCH8) Show undefined attributes

authored	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
catalystActivity	[CatalystActivity:1169400] ISG15 conjugating enzyme activity of UBE2L6 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643686] ISG15 conjugating enzyme activity of UBE2L6 [cytosol] Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
dbId	1169404
displayName	Transfer of ISG15 from E1 to E2 (UBCH8)
edited	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
eventOf	[Pathway:R-HSA-1169408] ISG15 antiviral mechanism - Homo sapiens
followingEvent	[Reaction:R-HSA-1169403] Interaction of E3 ligase with ISG15:E2 complex - Homo sapiens
input	[Complex:R-HSA-1169390] ISG15:UBA7 [cytosol] [EntityWithAccessionedSequence:R-HSA-936014] UBE2L6 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1169365] The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein [LiteratureReference:1678819] Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein [LiteratureReference:1169315] Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation [LiteratureReference:1169360] The basis for selective E1-E2 interactions in the ISG15 conjugation system
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Transfer of ISG15 from E1 to E2 (UBCH8)
orthologousEvent	[Reaction:R-DDI-1169404] Transfer of ISG15 from E1 to E2 (UBCH8) - Dictyostelium discoideum [Reaction:R-CEL-1169404] Transfer of ISG15 from E1 to E2 (UBCH8) - Caenorhabditis elegans [Reaction:R-SSC-1169404] Transfer of ISG15 from E1 to E2 (UBCH8) - Sus scrofa [Reaction:R-BTA-1169404] Transfer of ISG15 from E1 to E2 (UBCH8) - Bos taurus [Reaction:R-RNO-1169404] Transfer of ISG15 from E1 to E2 (UBCH8) - Rattus norvegicus [Reaction:R-MMU-1169404] Transfer of ISG15 from E1 to E2 (UBCH8) - Mus musculus
output	[Complex:R-HSA-1169385] ISG15:UBCH8 [cytosol] [EntityWithAccessionedSequence:R-HSA-936550] UBA7 [cytosol]
precedingEvent	[Reaction:R-HSA-1169397] Activation of ISG15 by UBA7 E1 enzyme - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213478] Zhang, DE, 2011-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1169404
summation	[Summation:1169305] Activated ISG15 linked to UBE1L is transferred to the E2 con...

Referrals

(hasEvent)	[Pathway:R-HSA-1169408] ISG15 antiviral mechanism
(precedingEvent)	[Reaction:R-HSA-1169403] Interaction of E3 ligase with ISG15:E2 complex