Reactome | L-Arg [cytosol]

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L-Arg [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-BTA-9640263] CASTOR1:L-Arg [cytosol] - Bos taurus [Complex:R-DME-9640172] SLC38A9:L-Arg [lysosomal membrane] - Drosophila melanogaster
consumedByEvent	[Reaction:R-HSA-379993] arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate - Homo sapiens [FailedReaction:R-HSA-5660910] Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane - Homo sapiens [BlackBoxEvent:R-GGA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Gallus gallus [BlackBoxEvent:R-GGA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Gallus gallus [BlackBoxEvent:R-XTR-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Xenopus tropicalis [BlackBoxEvent:R-XTR-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Xenopus tropicalis [BlackBoxEvent:R-DRE-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Danio rerio [BlackBoxEvent:R-DRE-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Danio rerio [BlackBoxEvent:R-SSC-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Sus scrofa [BlackBoxEvent:R-SSC-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Sus scrofa [BlackBoxEvent:R-BTA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Bos taurus [BlackBoxEvent:R-BTA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Bos taurus [BlackBoxEvent:R-CFA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Canis familiaris [BlackBoxEvent:R-CFA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Canis familiaris [BlackBoxEvent:R-RNO-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Rattus norvegicus [BlackBoxEvent:R-RNO-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Rattus norvegicus [BlackBoxEvent:R-MMU-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Mus musculus [BlackBoxEvent:R-MMU-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Mus musculus [BlackBoxEvent:R-HSA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Homo sapiens [BlackBoxEvent:R-HSA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Homo sapiens [Reaction:R-DME-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Drosophila melanogaster [Reaction:R-XTR-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Xenopus tropicalis [Reaction:R-DRE-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Danio rerio [Reaction:R-SSC-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Sus scrofa [Reaction:R-BTA-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Bos taurus [Reaction:R-RNO-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Rattus norvegicus [Reaction:R-MMU-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Mus musculus [Reaction:R-HSA-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Homo sapiens [Reaction:R-DME-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Drosophila melanogaster [Reaction:R-XTR-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Xenopus tropicalis [Reaction:R-DRE-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Danio rerio [Reaction:R-BTA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Bos taurus [Reaction:R-CFA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Canis familiaris [Reaction:R-RNO-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Rattus norvegicus [Reaction:R-MMU-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Mus musculus [Reaction:R-HSA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Homo sapiens [Reaction:R-PFA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Plasmodium falciparum [Reaction:R-SCE-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Saccharomyces cerevisiae [Reaction:R-SPO-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Schizosaccharomyces pombe [Reaction:R-DDI-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Dictyostelium discoideum [Reaction:R-DME-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Drosophila melanogaster [Reaction:R-GGA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Gallus gallus [Reaction:R-DRE-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Danio rerio [Reaction:R-SSC-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Sus scrofa [Reaction:R-BTA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Bos taurus [Reaction:R-CFA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Canis familiaris [Reaction:R-RNO-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Rattus norvegicus [Reaction:R-MMU-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Mus musculus [Reaction:R-HSA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Homo sapiens [Reaction:R-PFA-70569] arginine + H2O => ornithine + urea [ARG1] - Plasmodium falciparum [Reaction:R-SCE-70569] arginine + H2O => ornithine + urea [ARG1] - Saccharomyces cerevisiae [Reaction:R-SPO-70569] arginine + H2O => ornithine + urea [ARG1] - Schizosaccharomyces pombe [Reaction:R-DDI-70569] arginine + H2O => ornithine + urea [ARG1] - Dictyostelium discoideum [Reaction:R-HSA-350598] Arginine<=>Agmatine+CO2 - Homo sapiens [Reaction:R-MMU-350598] Arginine<=>Agmatine+CO2 - Mus musculus [Reaction:R-RNO-350598] Arginine<=>Agmatine+CO2 - Rattus norvegicus [Reaction:R-CFA-350598] Arginine<=>Agmatine+CO2 - Canis familiaris [Reaction:R-BTA-350598] Arginine<=>Agmatine+CO2 - Bos taurus [Reaction:R-SSC-350598] Arginine<=>Agmatine+CO2 - Sus scrofa [Reaction:R-DRE-350598] Arginine<=>Agmatine+CO2 - Danio rerio [Reaction:R-XTR-350598] Arginine<=>Agmatine+CO2 - Xenopus tropicalis [Reaction:R-GGA-350598] Arginine<=>Agmatine+CO2 - Gallus gallus [Reaction:R-DME-350598] Arginine<=>Agmatine+CO2 - Drosophila melanogaster [Reaction:R-CEL-350598] Arginine<=>Agmatine+CO2 - Caenorhabditis elegans [Reaction:R-DDI-350598] Arginine<=>Agmatine+CO2 - Dictyostelium discoideum [Reaction:R-SPO-350598] Arginine<=>Agmatine+CO2 - Schizosaccharomyces pombe [Reaction:R-SCE-350598] Arginine<=>Agmatine+CO2 - Saccharomyces cerevisiae [Reaction:R-PFA-350598] Arginine<=>Agmatine+CO2 - Plasmodium falciparum [Reaction:R-MMU-70569] arginine + H2O => ornithine + urea [ARG1] - Mus musculus [Reaction:R-RNO-70569] arginine + H2O => ornithine + urea [ARG1] - Rattus norvegicus [Reaction:R-CFA-70569] arginine + H2O => ornithine + urea [ARG1] - Canis familiaris [Reaction:R-HSA-70569] arginine + H2O => ornithine + urea [ARG1] - Homo sapiens [Reaction:R-BTA-70569] arginine + H2O => ornithine + urea [ARG1] - Bos taurus [Reaction:R-SSC-70569] arginine + H2O => ornithine + urea [ARG1] - Sus scrofa [Reaction:R-DRE-70569] arginine + H2O => ornithine + urea [ARG1] - Danio rerio [Reaction:R-XTR-70569] arginine + H2O => ornithine + urea [ARG1] - Xenopus tropicalis [Reaction:R-DME-70569] arginine + H2O => ornithine + urea [ARG1] - Drosophila melanogaster [Reaction:R-CEL-70569] arginine + H2O => ornithine + urea [ARG1] - Caenorhabditis elegans [FailedReaction:R-HSA-9956512] ARG1 variants don't synthesize urea and ornithine - Homo sapiens [BlackBoxEvent:R-GGA-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 - Gallus gallus [BlackBoxEvent:R-XTR-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 - Xenopus tropicalis [BlackBoxEvent:R-DRE-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 - Danio rerio [BlackBoxEvent:R-SSC-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 - Sus scrofa [BlackBoxEvent:R-BTA-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 - Bos taurus [BlackBoxEvent:R-CFA-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 - Canis familiaris [BlackBoxEvent:R-RNO-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 - Rattus norvegicus [BlackBoxEvent:R-MMU-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 - Mus musculus [BlackBoxEvent:R-HSA-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 - Homo sapiens [Reaction:R-SCE-202127] eNOS synthesizes NO - Saccharomyces cerevisiae [Reaction:R-SCE-202127] eNOS synthesizes NO - Saccharomyces cerevisiae [Reaction:R-SPO-202127] eNOS synthesizes NO - Schizosaccharomyces pombe [Reaction:R-SPO-202127] eNOS synthesizes NO - Schizosaccharomyces pombe [Reaction:R-DDI-202127] eNOS synthesizes NO - Dictyostelium discoideum [Reaction:R-DDI-202127] eNOS synthesizes NO - Dictyostelium discoideum [Reaction:R-CEL-202127] eNOS synthesizes NO - Caenorhabditis elegans [Reaction:R-CEL-202127] eNOS synthesizes NO - Caenorhabditis elegans [Reaction:R-DME-202127] eNOS synthesizes NO - Drosophila melanogaster [Reaction:R-DME-202127] eNOS synthesizes NO - Drosophila melanogaster [Reaction:R-BTA-202127] eNOS synthesizes NO - Bos taurus [Reaction:R-BTA-202127] eNOS synthesizes NO - Bos taurus [Reaction:R-RNO-202127] eNOS synthesizes NO - Rattus norvegicus [Reaction:R-RNO-202127] eNOS synthesizes NO - Rattus norvegicus [Reaction:R-MMU-202127] eNOS synthesizes NO - Mus musculus [Reaction:R-MMU-202127] eNOS synthesizes NO - Mus musculus [Reaction:R-HSA-202127] eNOS synthesizes NO - Homo sapiens [Reaction:R-HSA-202127] eNOS synthesizes NO - Homo sapiens
crossReference	[DatabaseIdentifier:29469] COMPOUND:C00062
dbId	29468
displayName	L-Arg [cytosol]
inDisease	false
maxDepth	1
memberOf	[DefinedSet:R-ALL-5687524] L-Arg,L-Asn [cytosol] [DefinedSet:R-ALL-375459] SLC6A14 ligands [cytosol]
modified	[InstanceEdit:9619952] Wu, G, 2018-09-19
name	L-Arg (S)-2-Amino-5-guanidinovaleric acid L-argininium(1+) L-arginine
producedByEvent	[Reaction:R-DDI-8936442] MARC1,MARC2 reduce N-hydroxylated compounds - Dictyostelium discoideum [Reaction:R-CEL-8936442] MARC1,MARC2 reduce N-hydroxylated compounds - Caenorhabditis elegans [Reaction:R-DME-8936442] MARC1,MARC2 reduce N-hydroxylated compounds - Drosophila melanogaster [Reaction:R-GGA-8936442] MARC1,MARC2 reduce N-hydroxylated compounds - Gallus gallus [Reaction:R-XTR-8936442] MARC1,MARC2 reduce N-hydroxylated compounds - Xenopus tropicalis [Reaction:R-DRE-8936442] MARC1,MARC2 reduce N-hydroxylated compounds - Danio rerio [Reaction:R-SSC-8936442] MARC1,MARC2 reduce N-hydroxylated compounds - Sus scrofa [Reaction:R-BTA-8936442] MARC1,MARC2 reduce N-hydroxylated compounds - Bos taurus [Reaction:R-CFA-8936442] MARC1,MARC2 reduce N-hydroxylated compounds - Canis familiaris [Reaction:R-RNO-8936442] MARC1,MARC2 reduce N-hydroxylated compounds - Rattus norvegicus [Reaction:R-MMU-8936442] MARC1,MARC2 reduce N-hydroxylated compounds - Mus musculus [Reaction:R-HSA-8936442] MARC1,MARC2 reduce N-hydroxylated compounds - Homo sapiens [Reaction:R-GGA-70573] argininosuccinate <=> fumarate + arginine - Gallus gallus [Reaction:R-SCE-70573] argininosuccinate <=> fumarate + arginine - Saccharomyces cerevisiae [Reaction:R-SPO-70573] argininosuccinate <=> fumarate + arginine - Schizosaccharomyces pombe [Reaction:R-HSA-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol - Homo sapiens [Reaction:R-MMU-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol - Mus musculus [Reaction:R-RNO-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol - Rattus norvegicus [Reaction:R-CFA-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol - Canis familiaris [Reaction:R-BTA-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol - Bos taurus [Reaction:R-SSC-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol - Sus scrofa [Reaction:R-DRE-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol - Danio rerio [Reaction:R-XTR-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol - Xenopus tropicalis [Reaction:R-GGA-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol - Gallus gallus [Reaction:R-DME-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol - Drosophila melanogaster [Reaction:R-CEL-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol - Caenorhabditis elegans [Reaction:R-DDI-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol - Dictyostelium discoideum [Reaction:R-MMU-70573] argininosuccinate <=> fumarate + arginine - Mus musculus [Reaction:R-RNO-70573] argininosuccinate <=> fumarate + arginine - Rattus norvegicus [Reaction:R-HSA-70573] argininosuccinate <=> fumarate + arginine - Homo sapiens [Reaction:R-CFA-70573] argininosuccinate <=> fumarate + arginine - Canis familiaris [Reaction:R-BTA-70573] argininosuccinate <=> fumarate + arginine - Bos taurus [Reaction:R-SSC-70573] argininosuccinate <=> fumarate + arginine - Sus scrofa [Reaction:R-DRE-70573] argininosuccinate <=> fumarate + arginine - Danio rerio [Reaction:R-XTR-70573] argininosuccinate <=> fumarate + arginine - Xenopus tropicalis [Reaction:R-DME-70573] argininosuccinate <=> fumarate + arginine - Drosophila melanogaster
referenceEntity	[ReferenceMolecule:chebi:32682] L-argininium(1+) [ChEBI:32682]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-29468
updateTrackers	[UpdateTracker:9891067] Update Tracker - [SimpleEntity:29468] L-Arg [cytosol] - v52:[modifyName] [UpdateTracker:9895116] Update Tracker - [SimpleEntity:29468] L-Arg [cytosol] - v59:[addName, add_removeReferenceEntity] [UpdateTracker:9874189] Update Tracker - [SimpleEntity:29468] L-Arg [cytosol] - v43:[addName]

Referrals

(hasComponent)	[Complex:R-DME-9640172] SLC38A9:L-Arg [lysosomal membrane] [Complex:R-CFA-9640172] SLC38A9:L-Arg [lysosomal membrane] [Complex:R-XTR-9640172] SLC38A9:L-Arg [lysosomal membrane] [Complex:R-BTA-9640172] SLC38A9:L-Arg [lysosomal membrane] [Complex:R-DRE-9640172] SLC38A9:L-Arg [lysosomal membrane] [Complex:R-MMU-9640172] SLC38A9:L-Arg [lysosomal membrane] [Complex:R-SSC-9640172] SLC38A9:L-Arg [lysosomal membrane] [Complex:R-CEL-9640172] SLC38A9:L-Arg [lysosomal membrane] [Complex:R-DDI-9640172] SLC38A9:L-Arg [lysosomal membrane] [Complex:R-SPO-9640172] SLC38A9:L-Arg [lysosomal membrane] [Complex:R-GGA-9640172] SLC38A9:L-Arg [lysosomal membrane] [Complex:R-RNO-9640172] SLC38A9:L-Arg [lysosomal membrane] [Complex:R-HSA-9640172] SLC38A9:L-Arg [lysosomal membrane] [Complex:R-BTA-9640263] CASTOR1:L-Arg [cytosol] [Complex:R-DRE-9640263] CASTOR1:L-Arg [cytosol] [Complex:R-XTR-9640263] CASTOR1:L-Arg [cytosol] [Complex:R-GGA-9640263] CASTOR1:L-Arg [cytosol] [Complex:R-MMU-9640263] CASTOR1:L-Arg [cytosol] [Complex:R-SSC-9640263] CASTOR1:L-Arg [cytosol] [Complex:R-CFA-9640263] CASTOR1:L-Arg [cytosol] [Complex:R-RNO-9640263] CASTOR1:L-Arg [cytosol] [Complex:R-HSA-9640263] CASTOR1:L-Arg [cytosol]
(input)	[Reaction:R-HSA-379993] arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate [FailedReaction:R-HSA-5660910] Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane [FailedReaction:R-HSA-9956512] ARG1 variants don't synthesize urea and ornithine [BlackBoxEvent:R-GGA-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-XTR-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-DRE-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-SSC-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-BTA-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-CFA-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-RNO-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-MMU-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-HSA-9640237] CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-GGA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-XTR-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-DRE-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-SSC-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-BTA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-CFA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-RNO-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-MMU-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 [BlackBoxEvent:R-HSA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 [Reaction:R-DME-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-XTR-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-DRE-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-SSC-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-BTA-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-RNO-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-MMU-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-HSA-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane [Reaction:R-DME-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-XTR-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-DRE-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-BTA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-CFA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-RNO-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-MMU-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-HSA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine [Reaction:R-SCE-202127] eNOS synthesizes NO [Reaction:R-SPO-202127] eNOS synthesizes NO [Reaction:R-DDI-202127] eNOS synthesizes NO [Reaction:R-CEL-202127] eNOS synthesizes NO [Reaction:R-DME-202127] eNOS synthesizes NO [Reaction:R-BTA-202127] eNOS synthesizes NO [Reaction:R-RNO-202127] eNOS synthesizes NO [Reaction:R-MMU-202127] eNOS synthesizes NO [Reaction:R-HSA-202127] eNOS synthesizes NO [Reaction:R-PFA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-SCE-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-SPO-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-DDI-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-DME-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-GGA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-DRE-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-SSC-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-BTA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-CFA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-RNO-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-MMU-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-HSA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) [Reaction:R-PFA-70569] arginine + H2O => ornithine + urea [ARG1] [Reaction:R-SCE-70569] arginine + H2O => ornithine + urea [ARG1] [Reaction:R-SPO-70569] arginine + H2O => ornithine + urea [ARG1] [Reaction:R-DDI-70569] arginine + H2O => ornithine + urea [ARG1] [Reaction:R-HSA-350598] Arginine<=>Agmatine+CO2 [Reaction:R-MMU-350598] Arginine<=>Agmatine+CO2 [Reaction:R-RNO-350598] Arginine<=>Agmatine+CO2 [Reaction:R-CFA-350598] Arginine<=>Agmatine+CO2 [Reaction:R-BTA-350598] Arginine<=>Agmatine+CO2 [Reaction:R-SSC-350598] Arginine<=>Agmatine+CO2 [Reaction:R-DRE-350598] Arginine<=>Agmatine+CO2 [Reaction:R-XTR-350598] Arginine<=>Agmatine+CO2 [Reaction:R-GGA-350598] Arginine<=>Agmatine+CO2 [Reaction:R-DME-350598] Arginine<=>Agmatine+CO2 [Reaction:R-CEL-350598] Arginine<=>Agmatine+CO2 [Reaction:R-DDI-350598] Arginine<=>Agmatine+CO2 [Reaction:R-SPO-350598] Arginine<=>Agmatine+CO2 [Reaction:R-SCE-350598] Arginine<=>Agmatine+CO2 [Reaction:R-PFA-350598] Arginine<=>Agmatine+CO2 [Reaction:R-MMU-70569] arginine + H2O => ornithine + urea [ARG1] [Reaction:R-RNO-70569] arginine + H2O => ornithine + urea [ARG1] [Reaction:R-CFA-70569] arginine + H2O => ornithine + urea [ARG1] [Reaction:R-HSA-70569] arginine + H2O => ornithine + urea [ARG1] [Reaction:R-BTA-70569] arginine + H2O => ornithine + urea [ARG1] [Reaction:R-SSC-70569] arginine + H2O => ornithine + urea [ARG1] [Reaction:R-DRE-70569] arginine + H2O => ornithine + urea [ARG1] [Reaction:R-XTR-70569] arginine + H2O => ornithine + urea [ARG1] [Reaction:R-DME-70569] arginine + H2O => ornithine + urea [ARG1] [Reaction:R-CEL-70569] arginine + H2O => ornithine + urea [ARG1]
(output)	[Reaction:R-DDI-8936442] MARC1,MARC2 reduce N-hydroxylated compounds [Reaction:R-CEL-8936442] MARC1,MARC2 reduce N-hydroxylated compounds [Reaction:R-DME-8936442] MARC1,MARC2 reduce N-hydroxylated compounds [Reaction:R-GGA-8936442] MARC1,MARC2 reduce N-hydroxylated compounds [Reaction:R-XTR-8936442] MARC1,MARC2 reduce N-hydroxylated compounds [Reaction:R-DRE-8936442] MARC1,MARC2 reduce N-hydroxylated compounds [Reaction:R-SSC-8936442] MARC1,MARC2 reduce N-hydroxylated compounds [Reaction:R-BTA-8936442] MARC1,MARC2 reduce N-hydroxylated compounds [Reaction:R-CFA-8936442] MARC1,MARC2 reduce N-hydroxylated compounds [Reaction:R-RNO-8936442] MARC1,MARC2 reduce N-hydroxylated compounds [Reaction:R-MMU-8936442] MARC1,MARC2 reduce N-hydroxylated compounds [Reaction:R-HSA-8936442] MARC1,MARC2 reduce N-hydroxylated compounds [Reaction:R-GGA-70573] argininosuccinate <=> fumarate + arginine [Reaction:R-SCE-70573] argininosuccinate <=> fumarate + arginine [Reaction:R-SPO-70573] argininosuccinate <=> fumarate + arginine [Reaction:R-HSA-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol [Reaction:R-MMU-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol [Reaction:R-RNO-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol [Reaction:R-CFA-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol [Reaction:R-BTA-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol [Reaction:R-SSC-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol [Reaction:R-DRE-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol [Reaction:R-XTR-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol [Reaction:R-GGA-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol [Reaction:R-DME-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol [Reaction:R-CEL-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol [Reaction:R-DDI-8952726] SLC38A9 transports L-Arg from lysosomal lumen to cytosol [Reaction:R-MMU-70573] argininosuccinate <=> fumarate + arginine [Reaction:R-RNO-70573] argininosuccinate <=> fumarate + arginine [Reaction:R-HSA-70573] argininosuccinate <=> fumarate + arginine [Reaction:R-CFA-70573] argininosuccinate <=> fumarate + arginine [Reaction:R-BTA-70573] argininosuccinate <=> fumarate + arginine [Reaction:R-SSC-70573] argininosuccinate <=> fumarate + arginine [Reaction:R-DRE-70573] argininosuccinate <=> fumarate + arginine [Reaction:R-XTR-70573] argininosuccinate <=> fumarate + arginine [Reaction:R-DME-70573] argininosuccinate <=> fumarate + arginine
(hasMember)	[DefinedSet:R-ALL-5687524] L-Arg,L-Asn [cytosol] [DefinedSet:R-ALL-8959777] SLC25A29 substrates [cytosol] [DefinedSet:R-ALL-352135] ligands of SLC38A4 [cytosol] [CandidateSet:R-ALL-375781] L-Arg, L-Lys, L-Orn [cytosol] [DefinedSet:R-ALL-379440] L-Arg, CySS-, L-Lys [cytosol] [DefinedSet:R-ALL-375459] SLC6A14 ligands [cytosol] [DefinedSet:R-ALL-8932842] L-Arg,L-His,L-Lys [cytosol]
(updatedInstance)	[UpdateTracker:9891067] Update Tracker - [SimpleEntity:29468] L-Arg [cytosol] - v52:[modifyName] [UpdateTracker:9895116] Update Tracker - [SimpleEntity:29468] L-Arg [cytosol] - v59:[addName, add_removeReferenceEntity] [UpdateTracker:9874189] Update Tracker - [SimpleEntity:29468] L-Arg [cytosol] - v43:[addName]

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