Reactome | Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)

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Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) Show undefined attributes

catalystActivity	[CatalystActivity:11059982] nitric-oxide synthase activity of NOS1,2,3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11059984
displayName	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)
eventOf	[Pathway:R-SPO-392154] Nitric oxide stimulates guanylate cyclase - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) - Homo sapiens
input	[SimpleEntity:R-ALL-29468] L-Arg [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)
output	[SimpleEntity:R-ALL-29968] L-Cit [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-202124] NO [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-418436
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-392154] Nitric oxide stimulates guanylate cyclase [Pathway:R-SPO-1222556] ROS and RNS production in phagocytes
(inferredTo)	[Reaction:R-HSA-418436] Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)

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