Reactome | CASTOR1 homodimer binds L-arginine and dissociates from GATOR2

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CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 Show undefined attributes

category	omitted
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10089326
displayName	CASTOR1 homodimer binds L-arginine and dissociates from GATOR2
eventOf	[Pathway:R-MMU-9639288] Amino acids regulate mTORC1 - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 - Homo sapiens
input	[Complex:R-MMU-9657634] KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] 2 × [SimpleEntity:R-ALL-29468] L-Arg [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CASTOR1 homodimer binds L-arginine and dissociates from GATOR2
output	[Complex:R-MMU-9657636] CASTOR1:L-Arg dimer [cytosol] [Complex:R-MMU-9639281] KICSTOR:GATOR1:GATOR2 [lysosomal membrane]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9657619
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9639288] Amino acids regulate mTORC1
(inferredTo)	[BlackBoxEvent:R-HSA-9657619] CASTOR1 homodimer binds L-arginine and dissociates from GATOR2

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