Reactome | argininosuccinate <=> fumarate + arginine

Schema > Reaction > Entries

argininosuccinate <=> fumarate + arginine Show undefined attributes

authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:70572] argininosuccinate lyase activity of ASL tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643560] argininosuccinate lyase activity of ASL tetramer [cytosol] Molecular analysis of human argininosuccinate lyase: mutant characterization and alternative splicing of the coding region
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667676] RHEA:24021
dbId	70573
diseaseReaction	[FailedReaction:R-HSA-9956524] ASL variants don't synthesize fumarate and arginine - Homo sapiens
displayName	argininosuccinate <=> fumarate + arginine
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
eventOf	[Pathway:R-HSA-70635] Urea cycle - Homo sapiens
followingEvent	[Reaction:R-HSA-70569] arginine + H2O => ornithine + urea [ARG1] - Homo sapiens
input	[SimpleEntity:R-ALL-34575] ARSUA [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:452044] Human argininosuccinate lyase: a structural basis for intragenic complementation [LiteratureReference:452031] Molecular analysis of human argininosuccinate lyase: mutant characterization and alternative splicing of the coding region
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	argininosuccinate <=> fumarate + arginine
orthologousEvent	[Reaction:R-MMU-70573] argininosuccinate <=> fumarate + arginine - Mus musculus [Reaction:R-RNO-70573] argininosuccinate <=> fumarate + arginine - Rattus norvegicus [Reaction:R-GGA-70573] argininosuccinate <=> fumarate + arginine - Gallus gallus [Reaction:R-CFA-70573] argininosuccinate <=> fumarate + arginine - Canis familiaris [Reaction:R-SCE-70573] argininosuccinate <=> fumarate + arginine - Saccharomyces cerevisiae [Reaction:R-SPO-70573] argininosuccinate <=> fumarate + arginine - Schizosaccharomyces pombe [Reaction:R-DME-70573] argininosuccinate <=> fumarate + arginine - Drosophila melanogaster [Reaction:R-XTR-70573] argininosuccinate <=> fumarate + arginine - Xenopus tropicalis [Reaction:R-DRE-70573] argininosuccinate <=> fumarate + arginine - Danio rerio [Reaction:R-SSC-70573] argininosuccinate <=> fumarate + arginine - Sus scrofa [Reaction:R-BTA-70573] argininosuccinate <=> fumarate + arginine - Bos taurus
output	[SimpleEntity:R-ALL-29586] FUMA [cytosol] [SimpleEntity:R-ALL-29468] L-Arg [cytosol]
precedingEvent	[Reaction:R-HSA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:452018] D'Eustachio, P, 2010-01-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70573
summation	[Summation:178476] Cytosolic argininosuccinate lyase (ASL) catalyzes the revers...
updateTrackers	[UpdateTracker:9791231] Update Tracker - [Reaction:70573] argininosuccinate <=> fumarate + arginine - v32:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791231] Update Tracker - [Reaction:70573] argininosuccinate <=> fumarate + arginine - v32:[add_removeLiteratureReference, modifyText]
(normalReaction)	[FailedReaction:R-HSA-9956524] ASL variants don't synthesize fumarate and arginine
(hasEvent)	[Pathway:R-HSA-70635] Urea cycle
(precedingEvent)	[Reaction:R-HSA-70569] arginine + H2O => ornithine + urea [ARG1]