Reactome | eNOS synthesizes NO

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eNOS synthesizes NO Show undefined attributes

catalystActivity	[CatalystActivity:10843931] nitric-oxide synthase activity of p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10843933
displayName	eNOS synthesizes NO
eventOf	[Pathway:R-DME-9009391] Extra-nuclear estrogen signaling - Drosophila melanogaster [Pathway:R-DME-5218920] VEGFR2 mediated vascular permeability - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-202127] eNOS synthesizes NO - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [SimpleEntity:R-ALL-29468] L-Arg [cytosol] 3 × [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	eNOS synthesizes NO H(+) + 2 L-arginine + 3 NADPH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide NO biosynthesis
output	4 × [SimpleEntity:R-ALL-29356] H2O [cytosol] 2 × [SimpleEntity:R-ALL-29968] L-Cit [cytosol] 3 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol] 2 × [SimpleEntity:R-ALL-202124] NO [cytosol]
precedingEvent	[Reaction:R-DME-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Drosophila melanogaster
regulatedBy	[NegativeRegulation:R-HSA-6783968] Negative regulation by 'ADMA [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-202127
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9009391] Extra-nuclear estrogen signaling [Pathway:R-DME-5218920] VEGFR2 mediated vascular permeability [Pathway:R-DME-203615] eNOS activation
(inferredTo)	[Reaction:R-HSA-202127] eNOS synthesizes NO

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