Reactome | argininosuccinate <=> fumarate + arginine

Schema > Reaction > Entries

argininosuccinate <=> fumarate + arginine Show undefined attributes

catalystActivity	[CatalystActivity:10652780] argininosuccinate lyase activity of ASL tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10652782
displayName	argininosuccinate <=> fumarate + arginine
eventOf	[Pathway:R-XTR-70635] Urea cycle - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-70569] arginine + H2O => ornithine + urea [ARG1] - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-70573] argininosuccinate <=> fumarate + arginine - Homo sapiens
input	[SimpleEntity:R-ALL-34575] ARSUA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	argininosuccinate <=> fumarate + arginine
output	[SimpleEntity:R-ALL-29586] FUMA [cytosol] [SimpleEntity:R-ALL-29468] L-Arg [cytosol]
precedingEvent	[Reaction:R-XTR-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-70573
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-70635] Urea cycle
(precedingEvent)	[Reaction:R-XTR-70569] arginine + H2O => ornithine + urea [ARG1]
(inferredTo)	[Reaction:R-HSA-70573] argininosuccinate <=> fumarate + arginine

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