Reactome | SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine

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SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine Show undefined attributes

catalystActivity	[CatalystActivity:10358548] amino acid transmembrane transporter activity of SLC7A6:SLC3A2 heterodimer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10358550
displayName	SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine
eventOf	[Pathway:R-BTA-352230] Amino acid transport across the plasma membrane - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine - Homo sapiens
input	[SimpleEntity:R-ALL-29468] L-Arg [cytosol] [SimpleEntity:R-ALL-351964] L-Leu [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine
output	[SimpleEntity:R-ALL-351977] L-Arg [extracellular region] [SimpleEntity:R-ALL-29588] L-Leu [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-379426
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-352230] Amino acid transport across the plasma membrane
(inferredTo)	[Reaction:R-HSA-379426] SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine

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