Reactome | SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane

Schema > Reaction > Entries

SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane Show undefined attributes

catalystActivity	[CatalystActivity:10580794] amino acid transmembrane transporter activity of SLC7A7:SLC3A2 heterodimer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10580796
displayName	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane
eventOf	[Pathway:R-DRE-352230] Amino acid transport across the plasma membrane - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29468] L-Arg [cytosol] [SimpleEntity:R-ALL-351964] L-Leu [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane SLC7A7 (y+LAT1)-mediated exchange of extracellular leucine for cytosolic arginine
output	[SimpleEntity:R-ALL-351977] L-Arg [extracellular region] [SimpleEntity:R-ALL-29588] L-Leu [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-379415
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-352230] Amino acid transport across the plasma membrane
(inferredTo)	[Reaction:R-HSA-379415] SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane

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