Lauren Thorpe

 ORCID
https://orcid.org/0000-0002-5302-9136
Affiliation
Dana-Farber Cancer Institute, Harvard Medical School
Reviewed Pathways (6/6)
Date Identifier Pathway Reference
2012-08-13 R-HSA-2219528 PI3K/AKT Signaling in Cancer BibTex
2012-08-13 R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer BibTex
2012-08-13 R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer BibTex
2012-08-13 R-HSA-5674404 PTEN Loss of Function in Cancer BibTex
2007-11-08 R-HSA-1257604 PIP3 activates AKT signaling BibTex
2007-11-08 R-HSA-199418 Negative regulation of the PI3K/AKT network BibTex
Reviewed Reactions (15/34)
Date Identifier Reaction Reference
2012-08-13 R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity BibTex
2012-08-13 R-HSA-2394007 PI3K gain of function mutants phosphorylate PIP2 to PIP3 BibTex
2012-08-13 R-HSA-2399992 AKT1 E17K mutant phosphorylates forkhead box transcription factors BibTex
2012-08-13 R-HSA-2399999 AKT1 E17K mutant phosphorylates RSK BibTex
2012-08-13 R-HSA-2399966 AKT1 E17K mutant phosphorylates GSK3 BibTex
2012-08-13 R-HSA-2399996 AKT1 E17K mutant phosphorylates CREB1 BibTex
2012-08-13 R-HSA-2399985 AKT1 E17K mutant phosphorylates caspase-9 BibTex
2012-08-13 R-HSA-2399988 AKT1 E17K mutant phosphorylates NR4A1 (NUR77) BibTex
2012-08-13 R-HSA-2399997 AKT1 E17K mutant translocates to the nucleus BibTex
2012-08-13 R-HSA-2400010 AKT inhibitors block AKT membrane recruitment BibTex
2012-08-13 R-HSA-2399977 AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) BibTex
2012-08-13 R-HSA-2399982 AKT1 E17K mutant phosphorylates TSC2, inhibiting it BibTex
2012-08-13 R-HSA-2399981 AKT1 E17K mutant phosphorylates MDM2 BibTex
2012-08-13 R-HSA-2400001 AKT1 E17K mutant phosphorylates CHUK (IKKalpha) BibTex
2012-08-13 R-HSA-2399969 AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 BibTex