AKT1 E17K mutant translocates to the nucleus

Stable Identifier
R-HSA-2399997
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
AKT1 E17K mutant translocates to the nucleus
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
AKT1 E17K gain-of-function mutant is expected to translocate to the nucleus, like the wild-type AKT (Borgatti et al. 2003), but this has not been directly experimentally tested.
Literature References
PubMed ID Title Journal Year
12767043 Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve growth factor stimulation and associates with the nuclear matrix protein nucleolin

Borgatti, P, Martelli, AM, Tabellini, G, Bellacosa, A, Capitani, S, Neri, LM

J Cell Physiol 2003
Participants
Input
Output
Participates
as an event of
Normal reaction
AKT translocates to the nucleus (Homo sapiens)
Functional status

Gain of function of p-T308,S473-AKT1 E17K [cytosol]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Orlic-Milacic, M  (2012-07-18)
Reviewed
Thorpe, L  (2012-08-13)
Yuzugullu, H  (2012-08-13)
Zhao, JJ  (2012-08-13)
Created
Orlic-Milacic, M  (2012-07-13)
Cite Us!