AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)

Stable Identifier
R-HSA-2399977
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AKT1 E17K gain-of-function mutant is expected to phosphorylate AKT1S1 (PRAS40), like the wild-type AKT (Kovacina et al. 2003), but this has not been experimentally tested.

Literature References
PubMed ID Title Journal Year
12524439 Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

Kovacina, KS, Park, GY, Bae, SS, Guzzetta, AW, Schaefer, E, Birnbaum, MJ, Roth, RA

J Biol Chem 2003
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]

Normal reaction
Functional status

Gain of function of p-T308,S473-AKT1 E17K [cytosol]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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