AKT1 E17K mutant phosphorylates CHUK (IKKalpha)

Stable Identifier
R-HSA-2400001
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AKT1 E17K mutant phosphorylates CHUK (IKKalpha)
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AKT1 E17K gain-of-function mutant is expected to phosphorylate CHUK (IKKalpha), like the wild-type AKT (Ozes et al. 1999), but this has not been experimentally tested.
Literature References
PubMed ID Title Journal Year
10485710 NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

Ozes, ON, Mayo, LD, Gustin, JA, Pfeffer, SR, Pfeffer, LM, Donner, DB

Nature 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]

Physical Entity
p-T308,S473-AKT1 E17K [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Normal reaction
AKT phosphorylates IKKalpha (Homo sapiens)
Functional status

Gain of function of p-T308,S473-AKT1 E17K [cytosol]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Orlic-Milacic, M  (2012-07-18)
Reviewed
Thorpe, L  (2012-08-13)
Yuzugullu, H  (2012-08-13)
Zhao, JJ  (2012-08-13)
Created
Orlic-Milacic, M  (2012-07-13)
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