AKT1 E17K mutant phosphorylates MDM2

Stable Identifier
R-HSA-2399981
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AKT1 E17K mutant phosphorylates MDM2
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AKT1 E17K gain-of-function mutant is expected to phosphorylate MDM2, like the wild-type AKT (Zhou et al. 2001, Feng et al. 2004, Milne et al. 2004), but this has not been experimentally tested.
Literature References
PubMed ID Title Journal Year
15527798 A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein

Milne, D, Kampanis, P, Nicol, S, Dias, S, Campbell, DG, Fuller-Pace, F, Meek, D

FEBS Lett. 2004
15169778 Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

Feng, J, Tamaskovic, R, Yang, Z, Brazil, DP, Merlo, A, Hess, D, Hemmings, BA

J. Biol. Chem. 2004
11715018 HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

Zhou, BP, Liao, Y, Xia, W, Zou, Y, Spohn, B, Hung, MC

Nat Cell Biol 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]

Physical Entity
p-T308,S473-AKT1 E17K [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Normal reaction
AKT phosphorylates MDM2 (Homo sapiens)
Functional status

Gain of function of p-T308,S473-AKT1 E17K [cytosol]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Orlic-Milacic, M  (2012-07-18)
Reviewed
Thorpe, L  (2012-08-13)
Yuzugullu, H  (2012-08-13)
Zhao, JJ  (2012-08-13)
Created
Orlic-Milacic, M  (2012-07-13)
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