AKT1 E17K mutant phosphorylates TSC2, inhibiting it

Stable Identifier
R-HSA-2399982
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AKT1 E17K mutant phosphorylates TSC2, inhibiting it
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AKT1 E17K gain-of-function mutant is expected to phosphorylate TSC2 and inhibit it, like the wild-type AKT (Inoki et al. 2002, Manning et al. 2002), but this has not been experimentally tested.
Literature References
PubMed ID Title Journal Year
12172553 TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K, Guan, KL, Li, Y, Wu, J, Zhu, T

Nat Cell Biol 2002
12150915 Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Tee, AR, Logsdon, MN, Manning, BD, Blenis, J, Cantley, LC

Mol Cell 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]

Physical Entity
p-T308,S473-AKT1 E17K [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Normal reaction
AKT phosphorylates TSC2, inhibiting it (Homo sapiens)
Functional status

Gain of function of p-T308,S473-AKT1 E17K [cytosol]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2012-07-18)
Reviewed
Zhao, JJ  (2012-08-13)
Yuzugullu, H  (2012-08-13)
Thorpe, L  (2012-08-13)
Created
Orlic-Milacic, M  (2012-07-13)
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