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FLT3 D835F [plasma membrane]
Stable Identifier
R-HSA-9682313
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
STK-1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Drug resistance of FLT3 mutants (Homo sapiens)
pexidartinib-resistant FLT3 mutants (Homo sapiens)
pexidartinib-resistant FLT3 mutants don't bind pexidartinib (Homo sapiens)
pexidartinib-resistant FLT3 mutants [plasma membrane] (Homo sapiens)
FLT3 D835F [plasma membrane] (Homo sapiens)
ponatinib-resistant FLT3 mutants (Homo sapiens)
ponatinib-resistant FLT3 mutants don't bind ponatinib (Homo sapiens)
ponatinib-resistant FLT3 mutants [plasma membrane] (Homo sapiens)
FLT3 D835F [plasma membrane] (Homo sapiens)
quizartinib-resistant FLT3 mutants (Homo sapiens)
quizartinib-resistant FLT3 mutants don't bind quizartinib (Homo sapiens)
quizartinib-resistant FLT3 mutants [plasma membrane] (Homo sapiens)
FLT3 D835F [plasma membrane] (Homo sapiens)
sorafenib-resistant FLT3 mutants (Homo sapiens)
sorafenib-resistant FLT3 mutants don't bind sorafenib (Homo sapiens)
sorafenib-resistant FLT3 mutants [plasma membrane] (Homo sapiens)
FLT3 D835F [plasma membrane] (Homo sapiens)
FLT3 mutants bind TKIs (Homo sapiens)
FLT mutants bind type I TKIs (Homo sapiens)
type I TKI sensitive FLT3 mutants [plasma membrane] (Homo sapiens)
crenolanib-sensitive FLT3 mutants [plasma membrane] (Homo sapiens)
FLT3 D835F dimer [plasma membrane] (Homo sapiens)
FLT3 D835F [plasma membrane] (Homo sapiens)
gilteritinib-sensitive FLT3 mutants [plasma membrane] (Homo sapiens)
FLT3 D835F dimer [plasma membrane] (Homo sapiens)
FLT3 D835F [plasma membrane] (Homo sapiens)
type I TKI-sensitive FLT3 mutants:type I TKIs [plasma membrane] (Homo sapiens)
type I TKI sensitive FLT3 mutants [plasma membrane] (Homo sapiens)
crenolanib-sensitive FLT3 mutants [plasma membrane] (Homo sapiens)
FLT3 D835F dimer [plasma membrane] (Homo sapiens)
FLT3 D835F [plasma membrane] (Homo sapiens)
gilteritinib-sensitive FLT3 mutants [plasma membrane] (Homo sapiens)
FLT3 D835F dimer [plasma membrane] (Homo sapiens)
FLT3 D835F [plasma membrane] (Homo sapiens)
Signaling by FLT3 ITD and TKD mutants (Homo sapiens)
Constitutive phosphorylation of FLT3 mutants (Homo sapiens)
FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
kinase domain mutant dimers of FLT3 [plasma membrane] (Homo sapiens)
FLT3 D835F dimer [plasma membrane] (Homo sapiens)
FLT3 D835F [plasma membrane] (Homo sapiens)
Ligand-independent dimerization of FLT3 mutants (Homo sapiens)
FLT3 extracellular domain, kinase domain and juxtamembrane domain mutant dimers [plasma membrane] (Homo sapiens)
kinase domain mutant dimers of FLT3 [plasma membrane] (Homo sapiens)
FLT3 D835F dimer [plasma membrane] (Homo sapiens)
FLT3 D835F [plasma membrane] (Homo sapiens)
FLT3 extracellular domain, kinase domain and juxtamembrane domain mutants [plasma membrane] (Homo sapiens)
kinase domain mutants of FLT3 [plasma membrane] (Homo sapiens)
FLT3 D835F [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36888 FLT3
Gene Names
FLT3, CD135, FLK2, STK1
Chain
signal peptide:1-26, chain:27-993
Reference Genes
BioGPS Gene:2322 FLT3
COSMIC (genes):FLT3 FLT3
CTD Gene:2322 FLT3
dbSNP Gene:2322 FLT3
ENSEMBL:ENSG00000122025 FLT3
HGNC:3765 FLT3
KEGG Gene (Homo sapiens):2322 FLT3
Monarch:2322 FLT3
NCBI Gene:2322 FLT3
OMIM:136351 FLT3
UCSC:P36888 FLT3
Reference Transcript
RefSeq:NM_004119.2 FLT3
Other Identifiers
0006290286
1065_at
11737027_a_at
16777685
206674_at
2322
34583_at
3507201
3507202
3507205
3507206
3507207
3507210
3507211
3507212
3507213
3507216
3507217
3507218
3507219
3507221
3507222
3507223
3507224
3507225
3507226
3507228
3507229
3507230
3507231
3507233
3507234
3507237
3507239
3507242
3507243
3507244
7970737
GE58857
GO:0000165
GO:0000166
GO:0001776
GO:0002318
GO:0002328
GO:0002376
GO:0002521
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0004896
GO:0005021
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005783
GO:0005788
GO:0005829
GO:0005886
GO:0005887
GO:0006464
GO:0006468
GO:0006629
GO:0007165
GO:0007169
GO:0007275
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0010243
GO:0014068
GO:0016020
GO:0016021
GO:0016032
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019221
GO:0019838
GO:0030097
GO:0030098
GO:0030154
GO:0030183
GO:0031100
GO:0032991
GO:0033674
GO:0035259
GO:0035726
GO:0038084
GO:0042531
GO:0042592
GO:0042981
GO:0043167
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0043552
GO:0043621
GO:0044403
GO:0044877
GO:0046651
GO:0046777
GO:0048856
GO:0071345
GO:0071385
GO:0097028
ILMN_1766363
PH_hs_0000046
TC13000515.hg
TC13001385.hg
U02687_at
g4758395_3p_at
Participant Of
hasMember
pexidartinib-resistant FLT3 mutants [plasma membrane]
ponatinib-resistant FLT3 mutants [plasma membrane]
quizartinib-resistant FLT3 mutants [plasma membrane]
sorafenib-resistant FLT3 mutants [plasma membrane]
hasCandidate
kinase domain mutants of FLT3 [plasma membrane]
hasComponent
FLT3 D835F dimer [plasma membrane]
Other forms of this molecule
FLT3 F691I [plasma membrane]
FLT3 N676D [plasma membrane]
FLT3 R834Q [plasma membrane]
FLT3 Y572C [plasma membrane]
FLT3 A848P [plasma membrane]
FLT3 A627P [plasma membrane]
FLT3 F621L [plasma membrane]
p-Y768,Y969 FLT3 [plasma membrane]
Ub-pY FLT3 [endosome membrane]
Ub-pY FLT3 [plasma membrane]
FLT3 V592G [plasma membrane]
FLT3 Y589_F590insFYVDFREYEYDLKWEF [plasma membrane]
FLT3 F590G Y591D [plasma membrane]
FLT3 F594L [plasma membrane]
FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane]
FLT3 V579A [plasma membrane]
FLT3 Y599_D600insGLYVDFREYEY [plasma membrane]
FLT3 Y591_V592insVDFREDREHH [plasma membrane]
FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane]
FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane]
FLT3 Y591_V592insVDFREYEYDH [plasma membrane]
FLT3 F612_G613insGYVDFREYEYDLKWEFRPRENLF [plasma membrane]
FLT3 Y599_F600insFYVDFREYEYDLKWEF [plasma membrane]
FLT3 E598_Y599insYDLKWEFRRENLEFG [plasma membrane]
FLT3 N609_L610insSSDNEYFYVDFREYEYDLKW [plasma membrane]
FLT3 F594_R595insREYEYDL [plasma membrane]
FLT3 L601_K602insREYEYDL [plasma membrane]
FLT3 N609_L610insSSDNEYFYVDFREYEYDLKWEFPREN [plasma membrane]
FLT3 E596_Y597insRTDFRE [plasma membrane]
FLT3 D586_E587insEYFYVDFREY [plasma membrane]
FLT3 E598_Y599insFYVDFREY [plasma membrane]
FLT3 V592A [plasma membrane]
FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL [plasma membrane]
FLT3 E598_Y599insVDFREYE [plasma membrane]
FLT3 E598_Y599insFDFREYE [plasma membrane]
FLT3 K602_W603insYEYDLK [plasma membrane]
FLT3 L610_E611insLKWEFPRENL [plasma membrane]
FLT3 V579L [plasma membrane]
FLT3 F594V [plasma membrane]
FLT3 F594I [plasma membrane]
FLT3 V579E [plasma membrane]
FLT3 V592D [plasma membrane]
FLT3 V579I [plasma membrane]
FLT3 F594S [plasma membrane]
FLT3 D835del [plasma membrane]
FLT3 K663Q [plasma membrane]
FLT3 I836del [plasma membrane]
FLT3 D835N [plasma membrane]
FLT3 D835V [plasma membrane]
FLT3 Y842C [plasma membrane]
FLT3 D835H [plasma membrane]
FLT3 A627E_T628insYEYDLKWEFPRENLEFGKVLGSGAFGKVMNA [plasma membrane]
FLT3 I836LInsD [plasma membrane]
FLT3 D835E [plasma membrane]
FLT3 D835A [plasma membrane]
FLT3 D835Y [plasma membrane]
FLT3 N676K [plasma membrane]
FLT3 N841I [plasma membrane]
FLT3 F691L [plasma membrane]
FLT3 D839G [plasma membrane]
FLT3 K633N [plasma membrane]
FLT3 D839N [plasma membrane]
FLT3 N841Y [plasma membrane]
FLT3 D835G [plasma membrane]
FLT3 K633R [plasma membrane]
FLT3 N841T [plasma membrane]
FLT3 N676T [plasma membrane]
FLT3 N676S [plasma membrane]
FLT3 N841K [plasma membrane]
FLT3 D839H [plasma membrane]
FLT3 F691V [plasma membrane]
FLT3 N841H [plasma membrane]
FLT3 D839E [plasma membrane]
FLT3 Y842H [plasma membrane]
FLT3 S451F [plasma membrane]
p-6Y FLT3 N676K [plasma membrane]
p-6Y FLT3 D839G [plasma membrane]
p-6Y FLT3 D835A [plasma membrane]
p-6Y FLT3 I836del [plasma membrane]
p-6Y FLT3 D835H [plasma membrane]
p-6Y FLT3 D835del [plasma membrane]
p-6Y FLT3 D835Y [plasma membrane]
p-6Y FLT3 D835V [plasma membrane]
p-6Y FLT3 D835N [plasma membrane]
p-6Y FLT3 N841I [plasma membrane]
p-6Y FLT3 K663Q [plasma membrane]
p-6Y FLT3 F691L [plasma membrane]
p-6Y FLT3 Y842C [plasma membrane]
p-6Y FLT3 D835E [plasma membrane]
p-6Y FLT3 D839H [plasma membrane]
p-6Y FLT3 N841T [plasma membrane]
p-6Y FLT3 D839N [plasma membrane]
p-6Y FLT3 N676T [plasma membrane]
p-6Y FLT3 K633N [plasma membrane]
p-6Y FLT3 Y842H [plasma membrane]
p-6Y FLT3 N841K [plasma membrane]
p-6Y FLT3 D835F [plasma membrane]
p-6Y FLT3 N841H [plasma membrane]
p-6Y FLT3 K633R [plasma membrane]
p-6Y FLT3 D835G [plasma membrane]
p-6Y FLT3 F691V [plasma membrane]
p-6Y FLT3 N676S [plasma membrane]
p-6Y FLT3 N841Y [plasma membrane]
p-6Y FLT3 D839E [plasma membrane]
p-6Y FLT3 S451F [plasma membrane]
p-6Y FLT3 F590G Y591D [plasma membrane]
p-6Y FLT3 E596_Y597insRTDFRE [plasma membrane]
p-6Y FLT3 F594L [plasma membrane]
p-6Y FLT3 V592A [plasma membrane]
p-6Y FLT3 V579A [plasma membrane]
p-6Y FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane]
p-6Y FLT3 V592G [plasma membrane]
p-6Y FLT3 F594S [plasma membrane]
p-6Y FLT3 V579L [plasma membrane]
p-6Y FLT3 F594I [plasma membrane]
p-6Y FLT3 V579I [plasma membrane]
p-6Y FLT3 V592D [plasma membrane]
p-6Y FLT3 F594V [plasma membrane]
p-6Y FLT3 V579E [plasma membrane]
p-6Y FLT3 E598_Y599insVDFREYE [plasma membrane]
p-6Y FLT3 F594_R595insREYEYDL [plasma membrane]
p-6Y FLT3 E598_Y599insFYVDFREY [plasma membrane]
p-6Y FLT3 L601_K602insREYEYDL [plasma membrane]
p-6Y FLT3 L610_E611insLKWEFPRENL [plasma membrane]
p-6Y FLT3 A627E_T628insYEYDLKWEFPRENLEFGKVLGSGAFGKVMNA [plasma membrane]
p-6Y FLT3 N609_L610insSSDNEYFYVDFREYEYDLKW [plasma membrane]
p-6Y FLT3 N609_L610insSSDNEYFYVDFREYEYDLKWEFPREN [plasma membrane]
p-6Y FLT3 K602_W603insYEYDLK [plasma membrane]
p-6Y FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane]
p-6Y FLT3 Y589_F590insFYVDFREYEYDLKWEF [plasma membrane]
p-6Y FLT3 E598_Y599insFDFREYE [plasma membrane]
p-6Y FLT3 E598_Y599insYDLKWEFRRENLEFG [plasma membrane]
p-6Y FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane]
p-6Y FLT3 Y600_D601insGLYVDFREYEY [plasma membrane]
p-6Y FLT3 Y599_F600insFYVDFREYEYDLKWEF [plasma membrane]
p-6Y FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL [plasma membrane]
p-6Y FLT3 Y591_V592insVDFREDREHH [plasma membrane]
p-6Y FLT3 F612_G613insGYVDFREYEYDLKWEFRPRENLF [plasma membrane]
p-6Y FLT3 D586_E587insEYFYVDFREY [plasma membrane]
p-6Y FLT3 Y591_V592insVDFREYEYDH [plasma membrane]
p-6Y FLT3 I836LInsD [plasma membrane]
Autophosphorylated FLT3 [plasma membrane]
FLT3 [plasma membrane]
Modified Residues
Name
L-aspartic acid 835 replaced with L-phenylalanine
Coordinate
835
PsiMod
L-aspartic acid removal [MOD:01634]
A protein modification that effectively removes or replaces an L-aspartic acid.
L-phenylalanine residue [MOD:00023]
A protein modification that effectively converts a source amino acid residue to L-phenylalanine.
Disease
Name
Identifier
Synonyms
acute myeloid leukemia
9119
Leukemia, Myelocytic, acute, acute myeloblastic leukemia, acute myelogenous leukemia, AML - acute Myeloid Leukemia
cancer
162
malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
NP_004110.2
ZINC - World Drugs
FLT3_HUMAN
OpenTargets
ENSG00000122025
ZINC - FDA approved
FLT3_HUMAN
ZINC - Substances
FLT3_HUMAN
ZINC target
P36888
ZINC - Biogenic
FLT3_HUMAN
PRO
P36888
PDB
1RJB
,
6JQR
,
3QS7
,
5X02
,
4XUF
,
3QS9
,
6IL3
,
4RT7
ZINC - Investigational
FLT3_HUMAN
ZINC - Metabolites
FLT3_HUMAN
COSMIC
COSM19844
IntEnz
2.7.10.1
HPA
ENSG00000122025-FLT3
GeneCards
P36888
Ensembl
ENSP00000241453
,
ENSG00000122025
,
ENST00000241453
ZINC - Predictions - Purchasable
FLT3_HUMAN
Orphanet
16784
HMDB Protein
HMDBP01189
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P43405 SYK
6
SYK [plasma membrane]
(R-HSA-139844)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
p-6Y-SYK [cytosol]
(R-HSA-983586)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
0.737
22
UniProt:Q13322 GRB10
2
GRB10 [cytosol]
(R-HSA-110009)
p-Y GRB10 [cytosol]
(R-HSA-9706168)
0.591
6
UniProt:P42684 ABL2
1
ABL2 [cytosol]
(R-HSA-375998)
0.544
3
UniProt:Q8R4L0
1
Sla2 [cytosol]
(R-MMU-9706161)
0.524
14
UniProt:Q06124 PTPN11
4
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y546-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y546,Y584-PTPN11 [cytosol]
(R-HSA-162573)
0.462
2
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