p-6Y FLT3 A627E_T628insYEYDLKWEFPRENLEFGKVLGSGAFGKVMNA [plasma membrane]

Stable Identifier
R-HSA-9691924
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
STK-1
p-6Y FLT3 A627E_T628insYEYDLKWEFPRENLEFGKVLGSGAFGKVMNA [plasma membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
18483393 Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor

Breitenbuecher, F, Schnittger, S, Grundler, R, Markova, B, Carius, B, Brecht, A, Duyster, J, Haferlach, T, Huber, C, Fischer, T

Blood 2009
External Reference Information
External Reference
Gene Names
FLT3, CD135, FLK2, STK1
Chain
signal peptide:1-26, chain:27-993
Reference Transcript
Other Identifiers
0006290286
1065_at
11737027_a_at
16777685
206674_at
2322
34583_at
3507201
3507202
3507205
3507206
3507207
3507210
3507211
3507212
3507213
3507216
3507217
3507218
3507219
3507221
3507222
3507223
3507224
3507225
3507226
3507228
3507229
3507230
3507231
3507233
3507234
3507237
3507239
3507242
3507243
3507244
7970737
GE58857
GO:0000165
GO:0000166
GO:0001776
GO:0002318
GO:0002328
GO:0002376
GO:0002521
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0004896
GO:0005021
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005783
GO:0005788
GO:0005829
GO:0005886
GO:0005887
GO:0006464
GO:0006468
GO:0006629
GO:0007165
GO:0007169
GO:0007275
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0010243
GO:0014068
GO:0016020
GO:0016021
GO:0016032
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019221
GO:0019838
GO:0030097
GO:0030098
GO:0030154
GO:0030183
GO:0031100
GO:0032991
GO:0033674
GO:0035259
GO:0035726
GO:0038084
GO:0042531
GO:0042592
GO:0042981
GO:0043167
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0043552
GO:0043621
GO:0044403
GO:0044877
GO:0046651
GO:0046777
GO:0048856
GO:0071345
GO:0071385
GO:0097028
ILMN_1766363
PH_hs_0000046
TC13000515.hg
TC13001385.hg
U02687_at
g4758395_3p_at
Participant Of
Other forms of this molecule
Modified Residues
Name
L-alanine 627 replaced with L-glutamic acid
Coordinate
627
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-glutamic acid.
A protein modification that effectively removes or replaces an L-alanine.
Name
Insertion of residues 597 to 627 at 628 from UniProt:P36888 FLT3
Coordinate
628
Name
O4'-phospho-L-tyrosine at 589
Coordinate
589
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 591
Coordinate
591
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 599
Coordinate
599
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 768
Coordinate
768
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 955
Coordinate
955
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 969
Coordinate
969
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
acute myeloid leukemia 9119 Leukemia, Myelocytic, acute, acute myeloblastic leukemia, acute myelogenous leukemia, AML - acute Myeloid Leukemia
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Investigational
ZINC - Metabolites
IntEnz
GeneCards
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
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