FLT3 D835Y [plasma membrane]

Stable Identifier
R-HSA-9682353
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
STK-1
Icon
FLT3 D835Y [plasma membrane] icon
FLT3 D835Y [plasma membrane] icon
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
15256420 Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518

Gilliland, DG, Lokker, NA, Curley, DP, Clark, JJ, Giese, NA, Yu, JC, Cools, J

Blood 2004
11290608 Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

Yamamoto, Y, Shimazaki, C, Saito, H, Yagasaki, F, Takeshita, A, Nishimura, M, Kodera, Y, Asou, N, Ueda, R, Miyawaki, S, Suzuki, R, Akiyama, H, Ohno, R, Kuriyama, K, Saito, K, Kiyoi, H, Naoe, T, Motoji, T, Nakano, Y, Shinagawa, K

Blood 2001
External Reference Information
External Reference
UniProt:P36888 FLT3
Gene Names
FLT3, CD135, FLK2, STK1
Chain
signal peptide:1-26, chain:27-993
Reference Genes
BioGPS Gene:2322 FLT3
COSMIC (genes):FLT3 FLT3
CTD Gene:2322 FLT3
dbSNP Gene:2322 FLT3
ENSEMBL:ENSG00000122025 FLT3
HGNC:3765 FLT3
KEGG Gene (Homo sapiens):2322 FLT3
Monarch:2322 FLT3
NCBI Gene:2322 FLT3
OMIM:136351 FLT3
UCSC:P36888 FLT3
Reference Transcript
Other Identifiers
0006290286
1065_at
11737027_a_at
16777685
206674_at
2322
34583_at
3507201
3507202
3507205
3507206
3507207
3507210
3507211
3507212
3507213
3507216
3507217
3507218
3507219
3507221
3507222
3507223
3507224
3507225
3507226
3507228
3507229
3507230
3507231
3507233
3507234
3507237
3507239
3507242
3507243
3507244
7970737
GE58857
GO:0000165
GO:0000166
GO:0001776
GO:0002318
GO:0002328
GO:0002376
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0004896
GO:0005021
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005768
GO:0005783
GO:0005788
GO:0005829
GO:0005886
GO:0005887
GO:0006464
GO:0006468
GO:0006629
GO:0007165
GO:0007169
GO:0007275
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0010008
GO:0010243
GO:0014068
GO:0016020
GO:0016021
GO:0016032
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019221
GO:0019838
GO:0030097
GO:0030154
GO:0030183
GO:0031100
GO:0031410
GO:0032991
GO:0033674
GO:0035259
GO:0035726
GO:0038084
GO:0042531
GO:0042592
GO:0042981
GO:0043167
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0043552
GO:0043621
GO:0044403
GO:0044877
GO:0046651
GO:0046777
GO:0048856
GO:0051897
GO:0071345
GO:0071385
GO:0097028
HMNXSV003001807
ILMN_1766363
PH_hs_0000046
TC13000515.hg
TC13001385.hg
U02687_at
g4758395_3p_at
Participates
as a member of
as a component of
Other forms of this molecule
FLT3 F691I [plasma membrane]
FLT3 N676D [plasma membrane]
FLT3 R834Q [plasma membrane]
FLT3 Y572C [plasma membrane]
FLT3 A848P [plasma membrane]
FLT3 A627P [plasma membrane]
FLT3 F621L [plasma membrane]
p-Y768,Y969 FLT3 [plasma membrane]
Ub-pY FLT3 [endosome membrane]
Ub-pY FLT3 [plasma membrane]
FLT3 V592G [plasma membrane]
FLT3 Y589_F590insFYVDFREYEYDLKWEF [plasma membrane]
FLT3 F590G Y591D [plasma membrane]
FLT3 F594L [plasma membrane]
FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane]
FLT3 V579A [plasma membrane]
FLT3 Y599_D600insGLYVDFREYEY [plasma membrane]
FLT3 Y591_V592insVDFREDREHH [plasma membrane]
FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane]
FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane]
FLT3 Y591_V592insVDFREYEYDH [plasma membrane]
FLT3 F612_G613insGYVDFREYEYDLKWEFRPRENLF [plasma membrane]
FLT3 Y599_F600insFYVDFREYEYDLKWEF [plasma membrane]
FLT3 E598_Y599insYDLKWEFRRENLEFG [plasma membrane]
FLT3 N609_L610insSSDNEYFYVDFREYEYDLKW [plasma membrane]
FLT3 F594_R595insREYEYDL [plasma membrane]
FLT3 L601_K602insREYEYDL [plasma membrane]
FLT3 N609_L610insSSDNEYFYVDFREYEYDLKWEFPREN [plasma membrane]
FLT3 E596_Y597insRTDFRE [plasma membrane]
FLT3 D586_E587insEYFYVDFREY [plasma membrane]
FLT3 E598_Y599insFYVDFREY [plasma membrane]
FLT3 V592A [plasma membrane]
FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL [plasma membrane]
FLT3 E598_Y599insVDFREYE [plasma membrane]
FLT3 E598_Y599insFDFREYE [plasma membrane]
FLT3 K602_W603insYEYDLK [plasma membrane]
FLT3 L610_E611insLKWEFPRENL [plasma membrane]
FLT3 V579L [plasma membrane]
FLT3 F594V [plasma membrane]
FLT3 F594I [plasma membrane]
FLT3 V579E [plasma membrane]
FLT3 V592D [plasma membrane]
FLT3 V579I [plasma membrane]
FLT3 F594S [plasma membrane]
FLT3 D835del [plasma membrane]
FLT3 K663Q [plasma membrane]
FLT3 I836del [plasma membrane]
FLT3 D835N [plasma membrane]
FLT3 D835V [plasma membrane]
FLT3 Y842C [plasma membrane]
FLT3 D835H [plasma membrane]
FLT3 A627E_T628insYEYDLKWEFPRENLEFGKVLGSGAFGKVMNA [plasma membrane]
FLT3 I836LInsD [plasma membrane]
FLT3 D835E [plasma membrane]
FLT3 D835A [plasma membrane]
FLT3 N676K [plasma membrane]
FLT3 N841I [plasma membrane]
FLT3 F691L [plasma membrane]
FLT3 D839G [plasma membrane]
FLT3 K633N [plasma membrane]
FLT3 D839N [plasma membrane]
FLT3 N841Y [plasma membrane]
FLT3 D835G [plasma membrane]
FLT3 K633R [plasma membrane]
FLT3 N841T [plasma membrane]
FLT3 D835F [plasma membrane]
FLT3 N676T [plasma membrane]
FLT3 N676S [plasma membrane]
FLT3 N841K [plasma membrane]
FLT3 D839H [plasma membrane]
FLT3 F691V [plasma membrane]
FLT3 N841H [plasma membrane]
FLT3 D839E [plasma membrane]
FLT3 Y842H [plasma membrane]
FLT3 S451F [plasma membrane]
p-6Y FLT3 N676K [plasma membrane]
p-6Y FLT3 D839G [plasma membrane]
p-6Y FLT3 D835A [plasma membrane]
p-6Y FLT3 I836del [plasma membrane]
p-6Y FLT3 D835H [plasma membrane]
p-6Y FLT3 D835del [plasma membrane]
p-6Y FLT3 D835Y [plasma membrane]
p-6Y FLT3 D835V [plasma membrane]
p-6Y FLT3 D835N [plasma membrane]
p-6Y FLT3 N841I [plasma membrane]
p-6Y FLT3 K663Q [plasma membrane]
p-6Y FLT3 F691L [plasma membrane]
p-6Y FLT3 Y842C [plasma membrane]
p-6Y FLT3 D835E [plasma membrane]
p-6Y FLT3 D839H [plasma membrane]
p-6Y FLT3 N841T [plasma membrane]
p-6Y FLT3 D839N [plasma membrane]
p-6Y FLT3 N676T [plasma membrane]
p-6Y FLT3 K633N [plasma membrane]
p-6Y FLT3 Y842H [plasma membrane]
p-6Y FLT3 N841K [plasma membrane]
p-6Y FLT3 D835F [plasma membrane]
p-6Y FLT3 N841H [plasma membrane]
p-6Y FLT3 K633R [plasma membrane]
p-6Y FLT3 D835G [plasma membrane]
p-6Y FLT3 F691V [plasma membrane]
p-6Y FLT3 N676S [plasma membrane]
p-6Y FLT3 N841Y [plasma membrane]
p-6Y FLT3 D839E [plasma membrane]
p-6Y FLT3 S451F [plasma membrane]
p-6Y FLT3 F590G Y591D [plasma membrane]
p-6Y FLT3 E596_Y597insRTDFRE [plasma membrane]
p-6Y FLT3 F594L [plasma membrane]
p-6Y FLT3 V592A [plasma membrane]
p-6Y FLT3 V579A [plasma membrane]
p-6Y FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane]
p-6Y FLT3 V592G [plasma membrane]
p-6Y FLT3 F594S [plasma membrane]
p-6Y FLT3 V579L [plasma membrane]
p-6Y FLT3 F594I [plasma membrane]
p-6Y FLT3 V579I [plasma membrane]
p-6Y FLT3 V592D [plasma membrane]
p-6Y FLT3 F594V [plasma membrane]
p-6Y FLT3 V579E [plasma membrane]
p-6Y FLT3 E598_Y599insVDFREYE [plasma membrane]
p-6Y FLT3 F594_R595insREYEYDL [plasma membrane]
p-6Y FLT3 E598_Y599insFYVDFREY [plasma membrane]
p-6Y FLT3 L601_K602insREYEYDL [plasma membrane]
p-6Y FLT3 L610_E611insLKWEFPRENL [plasma membrane]
p-6Y FLT3 A627E_T628insYEYDLKWEFPRENLEFGKVLGSGAFGKVMNA [plasma membrane]
p-6Y FLT3 N609_L610insSSDNEYFYVDFREYEYDLKW [plasma membrane]
p-6Y FLT3 N609_L610insSSDNEYFYVDFREYEYDLKWEFPREN [plasma membrane]
p-6Y FLT3 K602_W603insYEYDLK [plasma membrane]
p-6Y FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane]
p-6Y FLT3 Y589_F590insFYVDFREYEYDLKWEF [plasma membrane]
p-6Y FLT3 E598_Y599insFDFREYE [plasma membrane]
p-6Y FLT3 E598_Y599insYDLKWEFRRENLEFG [plasma membrane]
p-6Y FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane]
p-6Y FLT3 Y600_D601insGLYVDFREYEY [plasma membrane]
p-6Y FLT3 Y599_F600insFYVDFREYEYDLKWEF [plasma membrane]
p-6Y FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL [plasma membrane]
p-6Y FLT3 Y591_V592insVDFREDREHH [plasma membrane]
p-6Y FLT3 F612_G613insGYVDFREYEYDLKWEFRPRENLF [plasma membrane]
p-6Y FLT3 D586_E587insEYFYVDFREY [plasma membrane]
p-6Y FLT3 Y591_V592insVDFREYEYDH [plasma membrane]
p-6Y FLT3 I836LInsD [plasma membrane]
FLT3 [plasma membrane]
Autophosphorylated FLT3 [plasma membrane]
Modified Residues
Name
L-aspartic acid 835 replaced with L-tyrosine
Coordinate
835
PsiMod
L-tyrosine residue
A protein modification that effectively converts a source amino acid residue to L-tyrosine.
L-aspartic acid removal [MOD:01634]
A protein modification that effectively removes or replaces an L-aspartic acid.
Disease
Name Identifier Synonyms
acute myeloid leukemia DOID:9119 Leukemia, Myelocytic, acute, acute myeloblastic leukemia, acute myelogenous leukemia, AML - acute Myeloid Leukemia
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
ZINC - Investigational
ZINC - Metabolites
COSMIC
IntEnz
HPA
GeneCards
Ensembl
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (5)
Cite Us!