Prevention of phagosomal-lysosomal fusion

Stable Identifier
Homo sapiens
Related Species
Mycobacterium tuberculosis
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Lipoarabinomannan (LAM) is transported to Mtb's outer cell wall. When Mtb is interned by the phagocyte, LAM is shedded into the phagocyte's membrane, gets incorporated into lipid rafts of the phagosomal membrane, where it acts to prevent phagosomal-lysosomal fusion (Welin et al. 2008, Gaur et al. 2014). Other processes that get inhibited include the cytoskeletal protein coronin-1A and the fusion mediator vacuolar protein sorting-associated protein 33B (VPS33B) (Deghmane et al. 2007, Bach et al. 2008). Also the Ras-related protein (Rab5) effector phosphatidylinositol 3-phosphate (PI3P) gets enzymatically depleted (Vergne et al. 2005).

Literature References
PubMed ID Title Journal Year
25232742 LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis

González-Nilo, FD, Banaei, N, Ehrt, S, Ren, K, Gaur, RL, Zare, RN, Jackson, M, Ernst, JD, Bhamidi, S, Gibbs, S, Blumenthal, A

PLoS Pathog. 2014
15753315 Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis

Deretic, V, Belisle, J, Lucas, M, Vergne, I, Lee, HH, Chua, J

Proc. Natl. Acad. Sci. U.S.A. 2005
18474358 Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B

Hmama, Z, Av-Gay, Y, Bach, H, Wong, D, Papavinasasundaram, KG

Cell Host Microbe 2008
18426888 Incorporation of Mycobacterium tuberculosis lipoarabinomannan into macrophage membrane rafts is a prerequisite for the phagosomal maturation block

Abdalla, H, Winberg, ME, Lerm, M, Rasmusson, B, Welin, A, Stendahl, O, Särndahl, E

Infect. Immun. 2008
17652161 Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation

Toyoshima, S, Hmama, Z, Av-Gay, Y, Deghmane, AE, Noubir, S, Itoh, S, Talal, A, Lo, R, Soulhine, H, Tam, A, Sendide, K, Bach, H, Soualhine, H

J. Cell. Sci. 2007
Event Information
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
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