EsxG:EsxH binds HGS

Stable Identifier
R-HSA-9635667
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
phagocytic vesicle lumen
ReviewStatus
5/5
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EsxG:EsxH binds HGS
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The complex of ESAT-6-like proteins EsxG:EsxH respond to sterile membrane damage, recognizing either the damaged membrane itself or recruited proteins (Mittal et al. 2016). The EsxG:EsxH complex disrupts membrane repair and host trafficking by binding to hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/Hrs) a component of human ESCRT (Mehra et al. 2013).
Literature References
PubMed ID Title Journal Year
24204276 Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking

Mehra, A, Zahra, A, Thompson, V, Sirisaengtaksin, N, Wells, A, Porto, M, Köster, S, Penberthy, K, Kubota, Y, Dricot, A, Rogan, D, Vidal, M, Hill, DE, Bean, AJ, Philips, JA

PLoS Pathog. 2013
30482832 Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response

Mittal, E, Skowyra, ML, Uwase, G, Tinaztepe, E, Mehra, A, Köster, S, Hanson, PI, Philips, JA

MBio 2018
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Mondo
Authored
Stephan, R  (2019-02-06)
Reviewed
Deffur, A  (2019-10-23)
Wilkinson, RJ  (2019-10-23)
Created
Pardo, AM  (2019-02-06)
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