esxG:esxH binds HGS

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Mycobacterium tuberculosis
Locations in the PathwayBrowser
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The complex of ESAT-6-like proteins esxG:esxH respond to sterile membrane damage, recognizing either the damaged membrane itself or recruited proteins (Mittal et al. 2016). The esxG:esxH complex disrupts membrane repair and host trafficking by binding to hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/Hrs) a component of human ESCRT (Mehra et al. 2013).

Literature References
PubMed ID Title Journal Year
30482832 Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response

Mittal, E, Skowyra, ML, Uwase, G, Tinaztepe, E, Mehra, A, Köster, S, Hanson, PI, Philips, JA

MBio 2018
24204276 Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking

Mehra, A, Zahra, A, Thompson, V, Sirisaengtaksin, N, Wells, A, Porto, M, Köster, S, Penberthy, K, Kubota, Y, Dricot, A, Rogan, D, Vidal, M, Hill, DE, Bean, AJ, Philips, JA

PLoS Pathog. 2013
Participant Of
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
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