Rv1410c transports lprG:LM,LAM from cytosol to the cell wall

Stable Identifier
R-HSA-9697077
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
Locations in the PathwayBrowser
General
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Lipoarabinomannan carrier protein (LprG) acts as a carrier of both lipoarabinomannan (LAM) and lipomannan (LM) through the Mtb plasma membrane, most likely transported by probable triacylglyceride transporter (Rv1410c) (Shukla et al. 2014, Martinot et al. 2016).

Literature References
PubMed ID Title Journal Year
25356793 Mycobacterium tuberculosis lipoprotein LprG binds lipoarabinomannan and determines its cell envelope localization to control phagolysosomal fusion

Shukla, S, Richardson, ET, Athman, JJ, Shi, L, Wearsch, PA, McDonald, D, Banaei, N, Boom, WH, Jackson, M, Harding, CV

PLoS Pathog. 2014
26751071 Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis

Martinot, AJ, Farrow, M, Bai, L, Layre, E, Cheng, TY, Tsai, JH, Iqbal, J, Annand, JW, Sullivan, ZA, Hussain, MM, Sacchettini, J, Moody, DB, Seeliger, JC, Rubin, EJ

PLoS Pathog. 2016
Participants
Participates
Catalyst Activity

glycolipid transfer activity of Rv1410c [cytosol]

Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created
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