Suppression of phagosomal maturation

Stable Identifier
R-HSA-9637687
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

The fate of phagosomes is usually directed by factors in the host phagocyte and involves flooding itself with superoxide, nitric oxide, and protons. Acidification is the prerequisite for later fusion with a lysosome. Mycobacterium tuberculosis (Mtb) releases substances that inhibit all of these processes, effectively arresting the phagosome in the present state and creating a protected niche for Mtb multiplication (Russell 2011, Stutz et al. 2018).

Literature References
PubMed ID Title Journal Year
29345343 Mycobacterium tuberculosis: Rewiring host cell signaling to promote infection

Stutz, MD, Clark, MP, Doerflinger, M, Pellegrini, M

J. Leukoc. Biol. 2018
21349098 Mycobacterium tuberculosis and the intimate discourse of a chronic infection

Russell, DG

Immunol Rev 2011
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created
Cite Us!