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Suppression of phagosomal maturation
Stable Identifier
R-HSA-9637687
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Response of Mtb to phagocytosis (Homo sapiens)
Suppression of phagosomal maturation (Homo sapiens)
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The fate of phagosomes is usually directed by factors in the host phagocyte and involves flooding itself with superoxide, nitric oxide, and protons. Acidification is the prerequisite for later fusion with a lysosome. Mycobacterium tuberculosis (Mtb) releases substances that inhibit all of these processes, effectively arresting the phagosome in the present state and creating a protected niche for Mtb multiplication (Russell 2011, Stutz et al. 2018).
Literature References
PubMed ID
Title
Journal
Year
21349098
Mycobacterium tuberculosis and the intimate discourse of a chronic infection
Russell, DG
Immunol Rev
2011
29345343
Mycobacterium tuberculosis: Rewiring host cell signaling to promote infection
Stutz, MD
,
Doerflinger, M
,
Pellegrini, M
,
Clark, MP
J. Leukoc. Biol.
2018
Participants
Events
Prevention of phagosomal-lysosomal fusion
(Homo sapiens)
Inhibition of nitric oxide production
(Homo sapiens)
Blockage of phagosome acidification
(Homo sapiens)
Participates
as an event of
Response of Mtb to phagocytosis (Homo sapiens)
Event Information
Go Biological Process
symbiont-mediated suppression of host innate immune response (0052170)
Disease
Name
Identifier
Synonyms
tuberculosis
DOID:399
tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R (2019-02-06)
Reviewed
Wilkinson, RJ (2019-10-23)
Deffur, A (2019-10-23)
Created
Jassal, B (2019-02-19)
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