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TSG101 [endosome membrane]
Stable Identifier
R-HSA-2980549
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
Tumor susceptibility gene 101 protein, TS101_HUMAN
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Late endosomal microautophagy (Homo sapiens)
Substrate translocates into late endosomal lumen (Homo sapiens)
ESCRT-I [endosome membrane] (Homo sapiens)
TSG101 [endosome membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Late Events (Homo sapiens)
HCMV Final Envelopment (Homo sapiens)
ESCRT Regulator Complex [cytosol] (Homo sapiens)
ESCRT-I [endosome membrane] (Homo sapiens)
TSG101 [endosome membrane] (Homo sapiens)
HCMV Formation of Final Envelopment Complex (Homo sapiens)
ESCRT Regulator Complex [cytosol] (Homo sapiens)
ESCRT-I [endosome membrane] (Homo sapiens)
TSG101 [endosome membrane] (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Assembly Of The HIV Virion (Homo sapiens)
Synthesis And Processing Of GAG, GAGPOL Polyproteins (Homo sapiens)
Membrane binding and targetting of GAG proteins (Homo sapiens)
Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex (Homo sapiens)
ESCRT-I [endosome membrane] (Homo sapiens)
TSG101 [endosome membrane] (Homo sapiens)
Transport of GAG to the Plasma Membrane (Homo sapiens)
ESCRT-I [endosome membrane] (Homo sapiens)
TSG101 [endosome membrane] (Homo sapiens)
Budding and maturation of HIV virion (Homo sapiens)
HIV Virion Budding (Homo sapiens)
Virion Budding Complex [plasma membrane] (Homo sapiens)
ESCRT-I [endosome membrane] (Homo sapiens)
TSG101 [endosome membrane] (Homo sapiens)
Recruitment Of HIV Virion Budding Machinery (Homo sapiens)
ESCRT-I [endosome membrane] (Homo sapiens)
TSG101 [endosome membrane] (Homo sapiens)
Virion Budding Complex [plasma membrane] (Homo sapiens)
ESCRT-I [endosome membrane] (Homo sapiens)
TSG101 [endosome membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Endosomal Sorting Complex Required For Transport (ESCRT) (Homo sapiens)
Cargo Recognition And Sorting (Homo sapiens)
ESCRT-I [endosome membrane] (Homo sapiens)
TSG101 [endosome membrane] (Homo sapiens)
ESCRT-I/Cargo Complex [endosome membrane] (Homo sapiens)
ESCRT-I [endosome membrane] (Homo sapiens)
TSG101 [endosome membrane] (Homo sapiens)
Cargo Sequestration (Homo sapiens)
ESCRT-I [endosome membrane] (Homo sapiens)
TSG101 [endosome membrane] (Homo sapiens)
ESCRT-I/Cargo Complex [endosome membrane] (Homo sapiens)
ESCRT-I [endosome membrane] (Homo sapiens)
TSG101 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99816 TSG101
Gene Names
TSG101
Chain
initiator methionine:1, chain:2-390
Reference Genes
BioGPS Gene:7251 TSG101
COSMIC (genes):TSG101 TSG101
CTD Gene:7251 TSG101
dbSNP Gene:7251 TSG101
ENSEMBL:ENSG00000074319 TSG101
HGNC:15971 TSG101
KEGG Gene (Homo sapiens):7251 TSG101
Monarch:7251 TSG101
NCBI Gene:7251 TSG101
OMIM:601387 TSG101
UCSC:Q99816 TSG101
Reference Transcript
RefSeq:NM_006292.3 TSG101
Other Identifiers
11715944_at
11753797_a_at
11753798_x_at
147_at
16736508
201758_at
3365444
3365445
3365446
3365450
3365451
3365464
3365465
3365466
3365471
3365475
3365476
3365477
3365478
3365480
3365481
7251
7947015
A_23_P75839
GE59479
GO:0000813
GO:0001558
GO:0003674
GO:0003677
GO:0003714
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005730
GO:0005737
GO:0005768
GO:0005769
GO:0005770
GO:0005771
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0006464
GO:0006513
GO:0006810
GO:0006858
GO:0006914
GO:0007034
GO:0007049
GO:0007050
GO:0007165
GO:0007175
GO:0008150
GO:0008283
GO:0008285
GO:0008333
GO:0009056
GO:0009058
GO:0010008
GO:0015031
GO:0016020
GO:0016032
GO:0016192
GO:0016197
GO:0016236
GO:0019058
GO:0019899
GO:0022607
GO:0030154
GO:0030216
GO:0030374
GO:0031410
GO:0031625
GO:0031901
GO:0031902
GO:0032182
GO:0032991
GO:0034641
GO:0036258
GO:0039702
GO:0040007
GO:0040008
GO:0040011
GO:0042059
GO:0042803
GO:0043130
GO:0043162
GO:0043226
GO:0043405
GO:0043657
GO:0044403
GO:0044877
GO:0045892
GO:0046755
GO:0046790
GO:0048306
GO:0048856
GO:0051301
GO:0070062
GO:0075733
GO:0090543
GO:0097352
GO:1902188
GO:1903508
GO:1903543
GO:1903551
GO:1903774
GO:1990182
GO:2000397
PH_hs_0025977
TC11001466.hg
U82130_at
g5454139_3p_at
Participant Of
hasComponent
ESCRT-I [endosome membrane]
Inferred To
tsg101 [endosome membrane] (Dictyostelium discoideum)
tsg101a [endosome membrane] (Danio rerio)
Ghost homologue of TSG101 [endosome membrane] (Sus scrofa)
Ghost homologue of TSG101 [endosome membrane] (Xenopus tropicalis)
TSG101 [endosome membrane] (Bos taurus)
TSG101 [endosome membrane] (Canis familiaris)
TSG101 [endosome membrane] (Drosophila melanogaster)
TSG101 [endosome membrane] (Gallus gallus)
tsg-101 [endosome membrane] (Caenorhabditis elegans)
Tsg101 [endosome membrane] (Mus musculus)
Tsg101 [endosome membrane] (Rattus norvegicus)
Cross References
RefSeq
NP_006283.1
OpenTargets
ENSG00000074319
GeneCards
Q99816
HPA
ENSG00000074319-TSG101
Ensembl
ENST00000251968
,
ENSP00000251968
,
ENSG00000074319
ZINC target
Q99816
PRO
Q99816
PDB
1KPQ
,
3P9G
,
3IV1
,
4ZNY
,
4EJE
,
3OBS
,
5VKG
,
1M4Q
,
3OBX
,
4YC1
,
2F0R
,
3P9H
,
1KPP
,
1S1Q
,
6VME
,
1M4P
,
3OBU
,
3OBQ
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14964 HGS
2
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
HGS [cytosol]
(R-HSA-182954)
0.721
5
UniProt:Q8N0S2 SYCE1
1
SYCE1 [nucleoplasm]
(R-HSA-912456)
0.718
6
UniProt:Q99LI8
1
Hgs [cytosol]
(R-MMU-182954)
0.683
5
UniProt:P46940 IQGAP1
3
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.581
5
UniProt:O95429 BAG4
3
BAG4(1-126):p-8Y FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853156)
BAG4 [cytosol]
(R-HSA-5212670)
BAG4(1-126):FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853157)
0.556
3
UniProt:Q96IF1 AJUBA
3
p-S-AJUBA [cytosol]
(R-HSA-2574841)
AJUBA [nucleoplasm]
(R-HSA-5687935)
AJUBA [cytosol]
(R-HSA-2564698)
0.556
3
UniProt:Q9Y3M2 CBY1
3
CBY1 [nucleoplasm]
(R-HSA-3769210)
pS20-CBY1 [nucleoplasm]
(R-HSA-3769356)
pS20-CBY1 [cytosol]
(R-HSA-3769354)
0.556
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
3
UniProt:Q13464 ROCK1
6
ROCK1 [secretory granule lumen]
(R-HSA-6804967)
ROCK1 [extracellular region]
(R-HSA-6806527)
ROCK1(1114-1354) [cytosol]
(R-HSA-212524)
ROCK1(1-1113) [cytosol]
(R-HSA-212523)
ROCK1 [cytosol]
(R-HSA-212509)
Activated ROCK1 [cytosol]
(R-HSA-4687777)
0.508
4
UniProt:Q9Y5K6 CD2AP
1
CD2AP [cytosol]
(R-HSA-373620)
0.499
2
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