Reactome | TSG101 [endosome membrane]

TSG101 [endosome membrane]

Stable Identifier

R-HSA-2980549

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Tumor susceptibility gene 101 protein, TS101_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99816 TSG101

Gene Names

TSG101

Chain

initiator methionine:1, chain:2-390

Reference Genes

BioGPS Gene:7251 TSG101

COSMIC (genes):TSG101 TSG101

CTD Gene:7251 TSG101

dbSNP Gene:7251 TSG101

ENSEMBL:ENSG00000074319 TSG101

HGNC:15971 TSG101

KEGG Gene (Homo sapiens):7251 TSG101

Monarch:7251 TSG101

NCBI Gene:7251 TSG101

OMIM:601387 TSG101

UCSC:Q99816 TSG101

Reference Transcript

RefSeq:NM_006292.3 TSG101

Other Identifiers

11715944_at

11753797_a_at

11753798_x_at

147_at

16736508

201758_at

3365444

3365445

3365446

3365450

3365451

3365464

3365465

3365466

3365471

3365475

3365476

3365477

3365478

3365480

3365481

7251

7947015

A_23_P75839

GE59479

GO:0000813

GO:0001558

GO:0003674

GO:0003677

GO:0003714

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005730

GO:0005737

GO:0005768

GO:0005769

GO:0005770

GO:0005771

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006464

GO:0006513

GO:0006810

GO:0006858

GO:0006914

GO:0007034

GO:0007049

GO:0007050

GO:0007165

GO:0007175

GO:0008150

GO:0008283

GO:0008285

GO:0008333

GO:0009056

GO:0009058

GO:0010008

GO:0015031

GO:0016020

GO:0016032

GO:0016192

GO:0016197

GO:0016236

GO:0019058

GO:0019899

GO:0022607

GO:0030154

GO:0030216

GO:0030374

GO:0031410

GO:0031625

GO:0031901

GO:0031902

GO:0032182

GO:0032991

GO:0034641

GO:0036258

GO:0039702

GO:0040007

GO:0040008

GO:0040011

GO:0042059

GO:0042803

GO:0043130

GO:0043162

GO:0043226

GO:0043405

GO:0043657

GO:0044403

GO:0044877

GO:0045892

GO:0046755

GO:0046790

GO:0048306

GO:0048856

GO:0051301

GO:0070062

GO:0075733

GO:0090543

GO:0097352

GO:1902188

GO:1903508

GO:1903543

GO:1903551

GO:1903774

GO:1990182

GO:2000397

PH_hs_0025977

TC11001466.hg

U82130_at

g5454139_3p_at

Participant Of

hasComponent

ESCRT-I [endosome membrane]

Inferred To

tsg101 [endosome membrane] (Dictyostelium discoideum)

tsg101a [endosome membrane] (Danio rerio)

Ghost homologue of TSG101 [endosome membrane] (Sus scrofa)

Ghost homologue of TSG101 [endosome membrane] (Xenopus tropicalis)

TSG101 [endosome membrane] (Bos taurus)

TSG101 [endosome membrane] (Canis familiaris)

TSG101 [endosome membrane] (Drosophila melanogaster)

TSG101 [endosome membrane] (Gallus gallus)

tsg-101 [endosome membrane] (Caenorhabditis elegans)

Tsg101 [endosome membrane] (Mus musculus)

Tsg101 [endosome membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_006283.1

OpenTargets

ENSG00000074319

GeneCards

Q99816

HPA

ENSG00000074319-TSG101

Ensembl

ENST00000251968, ENSP00000251968, ENSG00000074319

ZINC target

Q99816

PRO

Q99816

PDB

1KPQ, 3P9G, 3IV1, 4ZNY, 4EJE, 3OBS, 5VKG, 1M4Q, 3OBX, 4YC1, 2F0R, 3P9H, 1KPP, 1S1Q, 6VME, 1M4P, 3OBU, 3OBQ

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14964 HGS	2	HGS [phagocytic vesicle lumen] (R-HSA-9635660) HGS [cytosol] (R-HSA-182954)	0.721	5
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.718	6
UniProt:Q99LI8	1	Hgs [cytosol] (R-MMU-182954)	0.683	5
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.581	5
UniProt:O95429 BAG4	3	BAG4(1-126):p-8Y FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126):FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	3
UniProt:Q96IF1 AJUBA	3	p-S-AJUBA [cytosol] (R-HSA-2574841) AJUBA [nucleoplasm] (R-HSA-5687935) AJUBA [cytosol] (R-HSA-2564698)	0.556	3
UniProt:Q9Y3M2 CBY1	3	CBY1 [nucleoplasm] (R-HSA-3769210) pS20-CBY1 [nucleoplasm] (R-HSA-3769356) pS20-CBY1 [cytosol] (R-HSA-3769354)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3
UniProt:Q13464 ROCK1	6	ROCK1 [secretory granule lumen] (R-HSA-6804967) ROCK1 [extracellular region] (R-HSA-6806527) ROCK1(1114-1354) [cytosol] (R-HSA-212524) ROCK1(1-1113) [cytosol] (R-HSA-212523) ROCK1 [cytosol] (R-HSA-212509) Activated ROCK1 [cytosol] (R-HSA-4687777)	0.508	4
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.499	2