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polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
Stable Identifier
R-HSA-6804480
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Lethal, LMBL2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
PIAS1 SUMOylates L3MBTL2 with SUMO2 (Homo sapiens)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q969R5 L3MBTL2
Gene Names
L3MBTL2
Chain
chain:1-705
Reference Genes
BioGPS Gene:83746 L3MBTL2
COSMIC (genes):L3MBTL2 L3MBTL2
CTD Gene:83746 L3MBTL2
dbSNP Gene:83746 L3MBTL2
ENSEMBL:ENSG00000100395 L3MBTL2
ENSEMBL:ENSG00000100395.15 L3MBTL2
HGNC:18594 L3MBTL2
KEGG Gene (Homo sapiens):83746 L3MBTL2
Monarch:83746 L3MBTL2
NCBI Gene:83746 L3MBTL2
OMIM:611865 L3MBTL2
UCSC:Q969R5 L3MBTL2
Reference Transcript
RefSeq:NM_031488.4 L3MBTL2
Other Identifiers
11722457_a_at
1555815_PM_a_at
1555815_a_at
16930570
223205_PM_s_at
223205_s_at
3946706
3946709
3946712
3946713
3946714
3946716
3946717
3946719
3946722
3946723
3946724
3946725
3946727
3946728
3946732
3946735
3946737
3946738
3946739
3946740
64452_at
8073379
83746
A_14_P108467
A_23_P80353
A_24_P6135
GO:0005515
GO:0005634
GO:0005654
GO:0006325
GO:0006351
GO:0006355
GO:0008270
GO:0035064
GO:0042393
GO:0043226
GO:0046872
Hs.265327.0.A2_3p_a_at
Hs2.265327.2.S1_3p_s_at
ILMN_1710600
ILMN_2336109
PH_hs_0023933
PH_hs_0040133
TC22000334.hg
Participates
as an output of
PIAS1 SUMOylates L3MBTL2 with SUMO2 (Homo sapiens)
Other forms of this molecule
L3MBTL2 [nucleoplasm]
Inferred To
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(Danio rerio)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(Drosophila melanogaster)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(Gallus gallus)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(Mus musculus)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(Rattus norvegicus)
L3MBTL2 [nucleoplasm]
(Bos taurus)
l3mbtl2 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
sumoylated lysine (polySUMO2 [nucleoplasm]) at 675
Coordinate
675
Modification
polySUMO2 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (polySUMO2 [nucleoplasm]) at 700
Coordinate
700
Modification
polySUMO2 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_113676.2
OpenTargets
ENSG00000100395
GeneCards
Q969R5
HPA
ENSG00000100395-L3MBTL2
Ensembl
ENST00000452106
,
ENSP00000216237
,
ENSP00000414423
,
ENSG00000100395
,
ENST00000216237
PRO
Q969R5
Pharos - Targets
Q969R5
PDB
2W0T
,
3F70
,
3CEY
Interactors (59)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61244 MAX
1
MAX [nucleoplasm]
(R-HSA-3006627)
0.748
6
UniProt:Q8WUB8-2 PHF10
0.718
6
UniProt:P08048 ZFY
0.718
6
UniProt:Q8N7W2-2 BEND7
0.718
8
UniProt:P22234 PAICS
1
PAICS [cytosol]
(R-HSA-62502)
0.718
6
UniProt:Q96MF2 STAC3
0.718
6
UniProt:O75886 STAM2
2
Ub-STAM2 [cytosol]
(R-HSA-6782781)
STAM2 [cytosol]
(R-HSA-182965)
0.666
4
UniProt:Q9HAF1 MEAF6
1
MEAF6 [nucleoplasm]
(R-HSA-3318448)
0.666
4
UniProt:O15379 HDAC3
2
HDAC3 [nucleoplasm]
(R-HSA-442464)
Unfolded HDAC3 [cytosol]
(R-HSA-6813777)
0.645
6
UniProt:P31321 PRKAR1B
2
PRKAR1B [cytosol]
(R-HSA-57838)
PRKAR1B [ciliary base]
(R-HSA-5610409)
0.556
3
UniProt:P19237 TNNI1
1
TNNI1 [cytosol]
(R-HSA-390539)
0.556
3
UniProt:Q6FI91 Q6FI91
0.556
3
UniProt:Q9NYW8 RBAK
0.556
3
UniProt:Q6PI77 GASP3
0.556
3
UniProt:Q8IWZ5 TRI42
0.556
3
UniProt:Q9H257-2 CARD9
0.556
3
UniProt:Q9BWC9 CC106
0.556
3
UniProt:Q9NVV9 THAP1
0.556
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:Q9Y2J4 AMOTL2
1
AMOTL2 [cytosol]
(R-HSA-2028606)
0.556
3
IntAct:EBI-16439879 CCSB ORF ID
0.556
3
UniProt:Q9NRA8 4ET
0.556
3
UniProt:Q16656-4 NRF1
0.556
3
UniProt:Q66K14-2 TBC1D9B
0.556
3
UniProt:O75031 HSF2B
0.556
3
UniProt:Q9NTW7 ZF64B
0.556
3
UniProt:A1L3A9 A1L3A9
0.556
3
UniProt:Q8TAP6 CEP76
1
CEP76 [cytosol]
(R-HSA-380281)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:P78424 PO6F2
0.556
3
UniProt:Q5VSY0 GKAP1
0.556
3
UniProt:Q9Y2M2-2 SSUH2
0.556
3
UniProt:Q9HCK0 ZBT26
0.556
3
UniProt:Q969V4 TEKT1
0.556
3
IntAct:EBI-22523600 CCSB ORF ID
0.556
3
UniProt:P10074 TZAP
0.556
3
UniProt:Q3KNS6-3 Q3KNS63
0.556
3
UniProt:Q86UB2 BIVM
0.556
3
UniProt:Q9NTX9 F217B
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:Q7Z7K2 ZNF467
1
ZNF467 [nucleoplasm]
(R-HSA-8940332)
0.556
3
UniProt:Q5JST6 EFHC2
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:P50221 MEOX1
0.556
3
UniProt:Q86VP1 TAX1BP1
1
TAX1BP1 [cytosol]
(R-HSA-937346)
0.556
3
UniProt:Q86XT4 TRIM50
1
TRIM50 [cytosol]
(R-HSA-5688976)
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:Q8IWI9 MGA
1
MGA [nucleoplasm]
(R-HSA-8953093)
0.527
2
UniProt:O75461 E2F6
2
E2F6 [nucleoplasm]
(R-HSA-8953089)
p-S12-E2F6 [nucleoplasm]
(R-HSA-9007536)
0.527
3
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.527
3
UniProt:Q06587 RING1
1
RING1 [nucleoplasm]
(R-HSA-389113)
0.527
3
UniProt:Q99496 RNF2
1
RNF2 [nucleoplasm]
(R-HSA-389119)
0.527
3
UniProt:Q9BYE7 PCGF6
1
PCGF6 [nucleoplasm]
(R-HSA-8953572)
0.527
3
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.527
2
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.527
2
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.527
3
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.527
3
UniProt:Q08117-2 TLE5
0.488
2
UniProt:Q8N448 LNX2
0.488
2
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