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polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
Stable Identifier
R-HSA-6804480
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Lethal, LMBL2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
PIAS1 SUMOylates L3MBTL2 with SUMO2 (Homo sapiens)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q969R5 L3MBTL2
Gene Names
L3MBTL2
Chain
chain:1-705
Reference Genes
BioGPS Gene:83746 L3MBTL2
COSMIC (genes):L3MBTL2 L3MBTL2
CTD Gene:83746 L3MBTL2
dbSNP Gene:83746 L3MBTL2
ENSEMBL:ENSG00000100395 L3MBTL2
HGNC:18594 L3MBTL2
KEGG:hsa:83746 L3MBTL2
Monarch:83746 L3MBTL2
NCBI Gene:83746 L3MBTL2
OMIM:611865 L3MBTL2
UCSC:Q969R5 L3MBTL2
Reference Transcript
RefSeq:NM_031488.4 L3MBTL2
Other Identifiers
11722457_a_at
1555815_PM_a_at
1555815_a_at
16930570
223205_PM_s_at
223205_s_at
3946706
3946707
3946708
3946709
3946710
3946711
3946712
3946713
3946714
3946715
3946716
3946717
3946719
3946720
3946722
3946723
3946724
3946725
3946727
3946728
3946729
3946730
3946731
3946732
3946733
3946734
3946735
3946737
3946738
3946739
3946740
64452_at
8073379
83746
A_14_P108467
A_23_P80353
A_24_P6135
GE83262
GO:0003682
GO:0005515
GO:0005634
GO:0005654
GO:0006325
GO:0006355
GO:0008270
GO:0035064
GO:0042393
GO:0043226
GO:0045892
GO:0046872
Hs.265327.0.A2_3p_a_at
Hs2.265327.2.S1_3p_s_at
ILMN_1710600
ILMN_2336109
PH_hs_0023933
PH_hs_0040133
TC22000334.hg
Participates
as an output of
PIAS1 SUMOylates L3MBTL2 with SUMO2 (Homo sapiens)
Other forms of this molecule
L3MBTL2 [nucleoplasm]
Inferred To
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(Drosophila melanogaster)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(Gallus gallus)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(Mus musculus)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(Rattus norvegicus)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(Sus scrofa)
L3MBTL2 [nucleoplasm]
(Bos taurus)
l3mbtl2 [nucleoplasm]
(Danio rerio)
l3mbtl2 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
sumoylated lysine (polySUMO2 [nucleoplasm]) at 675
Coordinate
675
Modification
polySUMO2 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (polySUMO2 [nucleoplasm]) at 700
Coordinate
700
Modification
polySUMO2 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
OpenTargets
ENSG00000100395
ENSEMBL
ENSP00000216237
,
ENST00000452106
,
ENST00000216237
,
ENSP00000414423
HPA
ENSG00000100395-L3MBTL2
PRO
Q969R5
Pharos - Targets
Q969R5
GlyGen
Q969R5
PDB
3F70
,
2W0T
,
3CEY
Interactors (65)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61244 MAX
1
MAX [nucleoplasm]
(R-HSA-3006627)
0.803
8
UniProt:Q9HAF1 MEAF6
1
MEAF6 [nucleoplasm]
(R-HSA-3318448)
0.743
5
UniProt:Q8WUB8-2 PHF10
0.718
6
UniProt:P08048 ZFY
0.718
6
UniProt:Q8N7W2-2 BEND7
0.718
8
UniProt:P22234 PAICS
1
PAICS [cytosol]
(R-HSA-62502)
0.718
6
UniProt:Q96MF2 STAC3
0.718
6
UniProt:O75886 STAM2
2
Ub-STAM2 [cytosol]
(R-HSA-6782781)
STAM2 [cytosol]
(R-HSA-182965)
0.666
4
UniProt:O15379 HDAC3
2
HDAC3 [nucleoplasm]
(R-HSA-442464)
Unfolded HDAC3 [cytosol]
(R-HSA-6813777)
0.645
6
UniProt:O75461 E2F6
2
E2F6 [nucleoplasm]
(R-HSA-8953089)
p-S12-E2F6 [nucleoplasm]
(R-HSA-9007536)
0.643
6
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.643
5
UniProt:Q9BYE7 PCGF6
1
PCGF6 [nucleoplasm]
(R-HSA-8953572)
0.643
6
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.643
6
UniProt:Q06587 RING1
1
RING1 [nucleoplasm]
(R-HSA-389113)
0.643
5
UniProt:Q99496 RNF2
1
RNF2 [nucleoplasm]
(R-HSA-389119)
0.643
6
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.643
4
UniProt:Q8IWI9 MGA
1
MGA [nucleoplasm]
(R-HSA-8953093)
0.643
5
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.643
4
UniProt:P31321 PRKAR1B
2
PRKAR1B [cytosol]
(R-HSA-57838)
PRKAR1B [ciliary base]
(R-HSA-5610409)
0.556
3
UniProt:P19237 TNNI1
1
TNNI1 [cytosol]
(R-HSA-390539)
0.556
3
UniProt:Q6FI91 Q6FI91
0.556
3
UniProt:Q6PI77 GASP3
0.556
3
UniProt:Q9NYW8 RBAK
0.556
3
UniProt:Q8IWZ5 TRI42
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q9H257-2 CARD9
0.556
3
UniProt:Q9BWC9 CC106
0.556
3
UniProt:Q9NVV9 THAP1
0.556
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:Q9Y2J4 AMOTL2
1
AMOTL2 [cytosol]
(R-HSA-2028606)
0.556
3
IntAct:EBI-16439879 CCSB ORF ID
0.556
3
UniProt:Q9NRA8 4ET
0.556
3
UniProt:P50221 MEOX1
0.556
3
UniProt:Q86VP1 TAX1BP1
1
TAX1BP1 [cytosol]
(R-HSA-937346)
0.556
3
UniProt:Q86XT4 TRIM50
1
TRIM50 [cytosol]
(R-HSA-5688976)
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:Q5JST6 EFHC2
0.556
3
UniProt:Q7Z7K2 ZNF467
1
ZNF467 [nucleoplasm]
(R-HSA-8940332)
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:Q9NTX9 F217B
0.556
3
UniProt:Q86UB2 BIVM
0.556
3
UniProt:Q3KNS6-3 Q3KNS63
0.556
3
UniProt:P10074 TZAP
0.556
3
IntAct:EBI-22523600 CCSB ORF ID
0.556
3
UniProt:Q969V4 TEKT1
0.556
3
UniProt:Q9HCK0 ZBT26
0.556
3
UniProt:Q9Y2M2-2 SSUH2
0.556
3
UniProt:Q5VSY0 GKAP1
0.556
3
UniProt:P78424 PO6F2
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q8TAP6 CEP76
1
CEP76 [cytosol]
(R-HSA-380281)
0.556
3
UniProt:A1L3A9 A1L3A9
0.556
3
UniProt:Q9NTW7 ZF64B
0.556
3
UniProt:O75031 HSF2B
0.556
3
UniProt:Q66K14-2 TBC1D9B
0.556
3
UniProt:Q16656-4 NRF1
0.556
3
UniProt:Q92769 HDAC2
2
HDAC2 [nucleoplasm]
(R-HSA-205135)
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
0.527
3
UniProt:Q8IY57 YAF2
1
YAF2 [nucleoplasm]
(R-HSA-8937973)
0.527
6
UniProt:Q14188 TFDP2
1
TFDP2 [nucleoplasm]
(R-HSA-1362225)
0.527
4
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.527
4
UniProt:Q6MZP7 LIN54
1
LIN54 [nucleoplasm]
(R-HSA-389103)
0.527
3
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.527
2
UniProt:P36955 PEDF
0.499
2
UniProt:Q08117-2 TLE5
0.488
2
UniProt:Q8N448 LNX2
0.488
2
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