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ATP6V1C2 [cytosol]
Stable Identifier
R-HSA-912573
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Amino acids regulate mTORC1 (Homo sapiens)
RRAGA,B exchanges GDP for GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
RRAGA,B hydrolyzes GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
RRAGC,D exchanges GTP for GDP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
RRAGC,D hydrolyzes GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
mTORC1 binds RHEB:GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
ROS and RNS production in phagocytes (Homo sapiens)
Intraphagosomal pH is lowered to 5 by V-ATPase (Homo sapiens)
V-ATPase [phagocytic vesicle membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor recycling (Homo sapiens)
ATP6AP1 binds V-ATPase (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
Endosome acidification (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
ATP6AP1 binds V-ATPase (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
Iron uptake and transport (Homo sapiens)
Transferrin endocytosis and recycling (Homo sapiens)
ATP6AP1 binds V-ATPase (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
Acidification of Tf:TfR1 containing endosome (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1C [cytosol] (Homo sapiens)
ATP6V1C2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NEY4 ATP6V1C2
Gene Names
ATP6V1C2
Chain
chain:1-427
Reference Genes
COSMIC (genes):ATP6V1C2 ATP6V1C2
dbSNP Gene:245973 ATP6V1C2
ENSEMBL:ENSG00000143882 ATP6V1C2
Participates
as a member of
ATP6V1C [cytosol] (Homo sapiens)
Inferred To
Vha44 [cytosol]
(Drosophila melanogaster)
vha-11 [cytosol]
(Caenorhabditis elegans)
vatC [cytosol]
(Dictyostelium discoideum)
Atp6v1c2 [cytosol]
(Mus musculus)
Atp6v1c2 [cytosol]
(Rattus norvegicus)
ATP6V1C2 [cytosol]
(Bos taurus)
ATP6V1C2 [cytosol]
(Canis familiaris)
ATP6V1C2 [cytosol]
(Gallus gallus)
ATP6V1C2 [cytosol]
(Plasmodium falciparum)
ATP6V1C2 [cytosol]
(Sus scrofa)
vma5 [cytosol]
(Schizosaccharomyces pombe)
VMA5 [cytosol]
(Saccharomyces cerevisiae)
atp6v1c2 [cytosol]
(Xenopus tropicalis)
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21281 ATP6V1B2
1
ATP6V1B2 [cytosol]
(R-HSA-912598)
0.527
2
UniProt:P38606 ATP6V1A
1
ATP6V1A [cytosol]
(R-HSA-912602)
0.527
2
UniProt:O75348 ATP6V1G1
1
ATP6V1G1 [cytosol]
(R-HSA-912578)
0.527
2
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