TRAF3 R118W [cytosol]

Stable Identifier
R-HSA-5602321
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
TRAF3 R118W [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
20832341 Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis

PĂ©rez de Diego, R, Sancho-Shimizu, V, Lorenzo, L, Puel, A, Plancoulaine, S, Picard, C, Herman, M, Cardon, A, Durandy, A, Bustamante, J, Vallabhapurapu, S, Bravo, J, Warnatz, K, Chaix, Y, Cascarrigny, F, Lebon, P, Rozenberg, F, Karin, M, Tardieu, M, Al-Muhsen, S, Jouanguy, E, Zhang, SY, Abel, L, Casanova, JL

Immunity 2010
External Reference Information
External Reference
Gene Names
TRAF3, CAP1, CRAF1
Chain
chain:1-568
Other Identifiers
0000940739
11742091_a_at
11743501_a_at
11759502_at
16789080
1FLK
1FLL
1KZZ
1L0A
1RF3
1ZMS
208315_3p_x_at
208315_x_at
221571_at
2933
2ECY
2GKW
3553338
3553346
3553358
3553359
3553363
3553364
3553367
3553368
3553370
3553374
3553382
3553383
3553384
37057_s_at
43952_at
7187
7977018
A_23_P37068
A_32_P89837
AAA56753
AAA65732
AAA68195
AAC50112
AAD29276
AAH75086
AAH75087
AF110908
AK303172
AL117209
BAH13910
BC075086
BC075087
BX247977
CAD62311
CCDS55946
CCDS9975
ENSG00000131323
ENSP00000376500
ENSP00000445998
ENSP00000454207
ENST00000392745
ENST00000539721
ENST00000560371
EntrezGene:7187
g4507678_3p_a_at
g4507678_3p_at
g4507678_3p_x_at
GE59008
GO:0001817
GO:0002224
GO:0002376
GO:0003674
GO:0004842
GO:0005164
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005739
GO:0005768
GO:0005829
GO:0005886
GO:0006464
GO:0006915
GO:0006950
GO:0007165
GO:0008063
GO:0008150
GO:0008219
GO:0008270
GO:0009058
GO:0009898
GO:0016567
GO:0016579
GO:0016740
GO:0019899
GO:0019901
GO:0019903
GO:0030162
GO:0031410
GO:0031625
GO:0031996
GO:0032088
GO:0032648
GO:0032991
GO:0033209
GO:0034641
GO:0035631
GO:0035666
GO:0042981
GO:0043167
GO:0043226
GO:0045087
GO:0046872
GO:0050688
H0YL25
H0YL26
H0YMI8
HGNC:12033
HPA002933
Hs.297660.1.S2_3p_at
ILMN_1793154
ILMN_2383774
IPR001293
IPR001841
IPR002083
IPR008974
IPR012227
IPR013083
IPR017907
IPR027128
IPR037304
L38509
LRG_229
MIM:601896
MIM:614849
NM_001199427
NM_003300
NM_145725
NP_001186356
NP_003291
NP_663777
PF02176
PH_hs_0015383
PH_hs_0038599
SM00061
TC14000786.hg
TRAF3
TRAF3-203
TRAF3-204
TRAF3-208
U15637
U15637_s_at
U19260
U21092
uc001ymc.3
uc001ymd.3
uc010txy.3
UPI000000CBF9
UPI0001E88EE1
XM_011537118
XM_017021617
XM_017021618
XP_011535420
XP_016877106
XP_016877107
Participant Of
Other forms of this molecule
Modified Residues
Name
L-arginine 118 replaced with L-tryptophan
Coordinate
118
PsiMod
A protein modification that effectively removes or replaces an L-arginine.
A protein modification that effectively converts a source amino acid residue to L-tryptophan.
Disease
Name Identifier Synonyms
primary immunodeficiency disease 612 immune deficiency disorder, immunodeficiency syndrome, hypoimmunity
Cross References
OpenTargets
GeneCards
DOCK Blaster
PRO
BRENDA (Homo sapiens)
Orphanet
Interactors (38)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q92844 TANK  2 0.77 6
 UniProt:Q13546 RIPK1  9 0.675 4
 UniProt:Q8TDR0 TRAF3IP1  2 0.639 8
 UniProt:Q99558 MAP3K14  5 0.635 3
 UniProt:O00463 TRAF5      0.635 3
 UniProt:O43353 RIPK2  2 0.633 5
 UniProt:Q15628 TRADD  1 0.547 2
 UniProt:Q13490 BIRC2  5 0.527 3
 UniProt:P61964 WDR5  1 0.524 2
 UniProt:P25942 CD40      0.508 3
 UniProt:Q9QYP6 AZI2      0.499 2
 UniProt:P15314  1 0.499 2
 UniProt:A2APF7 A2APF7      0.499 2
 UniProt:Q52MB2 CC184      0.488 2
 UniProt:Q5T681 CJ062      0.488 2
 UniProt:Q8IYE1 CCD13      0.488 2
 UniProt:Q6ZSB9 ZBT49      0.488 2
 UniProt:O95721 SNAP29  3 0.488 2
 UniProt:Q7KZS0 Q7KZS0      0.488 2
 UniProt:Q8NAM6 ZSCA4      0.488 2
 UniProt:Q96D03 DDT4L      0.488 2
 UniProt:Q8N9N2-2 ASCC1      0.488 2
 UniProt:Q9UKD1 GMEB2      0.488 2
 UniProt:Q16543 CDC37  1 0.488 2
 UniProt:Q13114 TRAF3  5 0.488 2
 UniProt:Q86UB2 BIVM      0.488 2
 UniProt:Q8TBB1 LNX1  1 0.488 2
 UniProt:Q0D2K3 RIPP1      0.488 2
 UniProt:P28062-2 PSMB8      0.488 2
 IntAct:EBI-12191689 HEMGN      0.488 2
 UniProt:P54725 RAD23A  1 0.488 2
 UniProt:Q17RL8 Q17RL8      0.488 2
 UniProt:P78317 RNF4  2 0.488 2
 UniProt:Q96HA1-2 POM121      0.488 2
 UniProt:Q96PC2 IP6K3  1 0.488 4
 UniProt:Q96HA8 NTAQ1      0.488 2
 UniProt:O75928-2 PIAS2  1 0.488 2
 UniProt:Q9Y547 HSPB11  2 0.488 2