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K63polyUb-TRAF3 [cytosol]
Stable Identifier
R-HSA-936402
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K63 polyubiquitinated TRAF3
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
SARS-CoV-1 M protein interacts with TRAF3 (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
M:K63polyUb-TRAF3 [Golgi membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
OTUD5 deubiquitinates TRAF3 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TRAF3-dependent IRF activation pathway (Homo sapiens)
Phosphorylation and release of IRF3/IRF7 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
Recruitment of IRF3,IRF7 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xTBK1,IKBKE:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
Recruitment of TRAF3 to MAVS (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1 or IKBKE forms homodimers (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1, IKBKE are autophosphorylated at Ser172 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
Auto-ubiquitination of TRAF3 within activated TLR3 complex (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
IKKε (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 (Homo sapiens)
IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
IKKε (IKBKE) is phosphorylated within the activated TLR3 complex (Homo sapiens)
IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
p-S172-IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR3:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation (Homo sapiens)
IKKε (IKBKE) is ubiquitinated within the activated TLR3 complex (Homo sapiens)
IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
K63pUb-IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
OPTN binds TBK1 within the activated TLR3 complex (Homo sapiens)
OPTN:TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 (Homo sapiens)
K63polyUb-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:viral dsRNA:TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1 is phosphorylated within the activated TLR3 complex (Homo sapiens)
OPTN:TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
Auto-ubiquitination of TRAF3 (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Homo sapiens)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Homo sapiens)
p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Homo sapiens)
IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Homo sapiens)
IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
K63polyUb-IKBKE:K63polyUb-TANK:K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
OPTN binds TBK1 within the activated TLR4 complex (Homo sapiens)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
K63polyUb-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TANK:K63-poly-Ub-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1 is phosphorylated within the activated TLR4 complex (Homo sapiens)
OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ovarian tumor domain proteases (Homo sapiens)
OTUD5 deubiquitinates TRAF3 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13114 TRAF3
Gene Names
TRAF3, CAP1, CRAF1, CAP-1, TRAFAMN
Chain
chain:1-568
Reference Genes
BioGPS Gene:7187 TRAF3
COSMIC (genes):TRAF3 TRAF3
CTD Gene:7187 TRAF3
dbSNP Gene:7187 TRAF3
ENSEMBL:ENSG00000131323 TRAF3
ENSEMBL_homo_sapiens_GENE:ENSG00000131323.17 TRAF3
HGNC:12033 TRAF3
KEGG Gene (Homo sapiens):7187 TRAF3
Monarch:7187 TRAF3
NCBI Gene:7187 TRAF3
OMIM:601896 TRAF3
UCSC:Q13114 TRAF3
Reference Transcript
RefSeq:XM_017021617.1 TRAF3
RefSeq:NM_003300.3 TRAF3
RefSeq:NM_145725.2 TRAF3
RefSeq:XM_011537118.2 TRAF3
RefSeq:NM_001199427.1 TRAF3
RefSeq:XM_017021618.1 TRAF3
RefSeq:NM_145726.2 TRAF3
Other Identifiers
11742091_a_at
11743501_a_at
11759502_at
16789080
208315_3p_x_at
208315_PM_x_at
208315_x_at
221571_PM_at
221571_at
3553338
3553346
3553358
3553359
3553363
3553364
3553367
3553368
3553370
3553374
3553382
3553383
3553384
3553386
3553388
37057_s_at
43952_at
7187
7977018
A_23_P37068
A_32_P89837
GE59008
GO:0000151
GO:0001817
GO:0002224
GO:0002376
GO:0003824
GO:0004842
GO:0005164
GO:0005515
GO:0005737
GO:0005739
GO:0005768
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006915
GO:0007165
GO:0008063
GO:0008270
GO:0009898
GO:0010008
GO:0012501
GO:0016740
GO:0019899
GO:0019901
GO:0019903
GO:0023052
GO:0030162
GO:0031410
GO:0031625
GO:0031996
GO:0032088
GO:0032481
GO:0032648
GO:0033209
GO:0034142
GO:0035631
GO:0035666
GO:0036211
GO:0042802
GO:0042981
GO:0043122
GO:0043226
GO:0045087
GO:0046872
GO:0048584
GO:0050688
GO:0051607
GO:0060337
GO:0061630
GO:0070534
GO:0098542
GO:0140096
GO:1902554
HMNXSV003033530
Hs.297660.1.S2_3p_at
ILMN_2383774
PH_hs_0015383
PH_hs_0038599
TC14000786.hg
U15637_s_at
g4507678_3p_a_at
g4507678_3p_at
g4507678_3p_x_at
Participates
as a component of
M:K63polyUb-TRAF3 [Golgi membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] (Homo sapiens)
K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
as an input of
SARS-CoV-1 M protein interacts with TRAF3 (Homo sapiens)
Recruitment of TRAF3 to MAVS (Homo sapiens)
Other forms of this molecule
TRAF3 R118W [cytosol]
K48polyUb-TRAF3 [cytosol]
TRAF3 [cytosol]
Inferred To
Traf3 [cytosol]
(Mus musculus)
Traf3 [cytosol]
(Rattus norvegicus)
TRAF3 [cytosol]
(Bos taurus)
TRAF3 [cytosol]
(Canis familiaris)
TRAF3 [cytosol]
(Gallus gallus)
TRAF3 [cytosol]
(Sus scrofa)
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001186356.1
,
NP_663778.1
,
XP_016877106.1
,
NP_663777.1
,
XP_011535420.1
,
NP_003291.2
,
XP_016877107.1
OpenTargets
ENSG00000131323
HPA
ENSG00000131323-TRAF3
GeneCards
Q13114
Ensembl
ENST00000539721
,
ENSP00000454207
,
ENSG00000131323
,
ENSP00000514678
,
ENST00000392745
,
ENSP00000376500
,
ENSP00000445998
,
ENST00000699894
,
ENST00000560371
PRO
Q13114
Pharos - Targets
Q13114
Orphanet
20819
PDB
1FLK
,
8T5P
,
1ZMS
,
1KZZ
,
1FLL
,
1L0A
,
1RF3
,
2ECY
,
2GKW
Interactors (49)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99558 MAP3K14
5
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
0.918
10
UniProt:Q92844 TANK
2
TANK [cytosol]
(R-HSA-933407)
K63polyUb-TANK [cytosol]
(R-HSA-5362480)
0.87
8
UniProt:O95721 SNAP29
3
SNAP29 [azurophil granule membrane]
(R-HSA-6799359)
SNAP29 [plasma membrane]
(R-HSA-2029020)
SNAP29 [Golgi membrane]
(R-HSA-6810997)
0.742
6
UniProt:O43353 RIPK2
2
RIPK2 [cytosol]
(R-HSA-168402)
Ub-209-RIPK2 [cytosol]
(R-HSA-706483)
0.72
6
UniProt:Q13546 RIPK1
20
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
RIPK1 D324N [cytosol]
(R-HSA-9693930)
RIPK1 D324Y [cytosol]
(R-HSA-9693931)
RIPK1 D324V [cytosol]
(R-HSA-9693927)
RIPK1 D324H [cytosol]
(R-HSA-9693922)
RIPK1 [plasma membrane]
(R-HSA-937073)
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
(R-HSA-9796639)
K63,Met1polyUb-p-S25-RIPK1 [cytosol]
(R-HSA-9818793)
K63,M1polyUb-RIPK1 [cytosol]
(R-HSA-9793681)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(R-HSA-9818391)
K63,M1polyUb, p-T189-RIPK1 [cytosol]
(R-HSA-9817377)
p-S320-RIPK1 [cytosol]
(R-HSA-9815498)
p-S357-RIPK1 [cytosol]
(R-HSA-9819116)
p-S166-RIPK1 [cytosol]
(R-HSA-5218872)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
RIPK1 [endosome membrane]
(R-HSA-450326)
RIPK1 [cytosol]
(R-HSA-168651)
0.703
5
UniProt:Q9UHD2 TBK1
5
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
p-TBK1 [cytosol]
(R-HSA-9008705)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
TBK1 [cytosol]
(R-HSA-166267)
p-S172-TBK1 [cytosol]
(R-HSA-168379)
0.688
4
UniProt:P41212 ETV6
14
p-12Y-ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane]
(R-HSA-9673912)
p-11Y-ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane]
(R-HSA-9673905)
ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane]
(R-HSA-9673893)
ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane]
(R-HSA-9673898)
ETV6(1-384)-FLT3(569-993) fusion [cytosol]
(R-HSA-9697944)
ETV6(1-301)-FLT3(574-993) fusion [cytosol]
(R-HSA-9703315)
ETV6(1-384)-FLT3(573-993) fusion [cytosol]
(R-HSA-9703307)
ETV6(1-336)insGCS-FLT3(573-993) fusion [cytosol]
(R-HSA-9703320)
ETV6(1-154)insGSFILG-FLT3(573-993) fusion [cytosol]
(R-HSA-9703312)
ETV6(1-384)-p-3Y-FLT3(659-1620) fusion [cytosol]
(R-HSA-9703313)
ETV6(1-301)-p-6Y-FLT3(574-993) fusion [cytosol]
(R-HSA-9703318)
ETV6(1-336)insGCS-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703305)
ETV6(1-154)insGSFILG-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703302)
ETV6(1-384)-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703308)
0.671
5
UniProt:P36941 LTBR
1
LTBR [plasma membrane]
(R-HSA-5668750)
0.669
4
UniProt:Q9HAV5 EDA2R
1
EDA2R [plasma membrane]
(R-HSA-5669018)
0.669
3
UniProt:O00463 TRAF5
0.659
4
UniProt:Q8TDR0 TRAF3IP1
2
TRAF3IP1 [ciliary tip]
(R-HSA-5625404)
TRAF3IP1 [cilium]
(R-HSA-5617603)
0.639
8
UniProt:P0DTC5 M
10
M [plasma membrane]
(R-COV-9755780)
N-glycan M [virion membrane]
(R-COV-9694385)
M [virion membrane]
(R-COV-9694320)
M [endocytic vesicle membrane]
(R-COV-9694563)
N-glycan M [endocytic vesicle membrane]
(R-COV-9694738)
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694439)
N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694446)
M [endoplasmic reticulum membrane]
(R-COV-9767620)
nascent M [endoplasmic reticulum lumen]
(R-COV-9694279)
N-glycan M [endoplasmic reticulum membrane]
(R-COV-9694684)
0.573
4
UniProt:Q9UHJ6 SHPK
1
SHPK [cytosol]
(R-HSA-8959710)
0.564
2
UniProt:Q8IYE1 CCD13
0.556
3
UniProt:Q6ZSB9 ZBT49
0.556
3
UniProt:P28062-2 PSMB8
0.556
3
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.556
3
UniProt:P78317 RNF4
2
RNF4 [nucleoplasm]
(R-HSA-5684076)
RNF4 [cytosol]
(R-HSA-975974)
0.556
3
UniProt:Q96HA1-2 POM121
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:Q52MB2 CC184
0.556
3
UniProt:Q5T681 CJ062
0.556
3
UniProt:Q7KZS0 Q7KZS0
0.556
3
UniProt:Q8N9N2-2 ASCC1
0.556
3
UniProt:Q9UKD1 GMEB2
0.556
3
UniProt:O75928-2 PIAS2
1
PIAS2-2 [nucleoplasm]
(R-HSA-2993779)
0.556
3
UniProt:Q9Y547 HSPB11
2
HSPB11 [ciliary tip]
(R-HSA-5625342)
HSPB11 [cilium]
(R-HSA-5617628)
0.556
3
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.556
3
UniProt:Q13114 TRAF3
4
TRAF3 R118W [cytosol]
(R-HSA-5602321)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 [cytosol]
(R-HSA-914241)
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
0.556
5
UniProt:Q86UB2 BIVM
0.556
6
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:Q0D2K3 RIPP1
0.556
3
IntAct:EBI-22505066 CCSB ORF ID
0.556
3
UniProt:Q17RL8 Q17RL8
0.556
3
UniProt:Q96PC2 IP6K3
1
IP6K3 [cytosol]
(R-HSA-1604594)
0.556
5
UniProt:Q8NAM6 ZSCAN4
1
ZSCAN4 [nucleoplasm]
(R-HSA-9816447)
0.556
3
UniProt:Q01844 EWS
0.547
2
UniProt:Q15628 TRADD
1
TRADD [cytosol]
(R-HSA-66376)
0.547
2
UniProt:Q13011 ECH1
3
ECH1 [mitochondrial matrix]
(R-HSA-9838037)
ECH1(1-328) [peroxisomal matrix]
(R-HSA-9033140)
ECH1(1-328) [cytosol]
(R-HSA-9033152)
0.527
2
UniProt:Q9UJT2 TSKS
0.527
2
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.527
3
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.527
3
UniProt:P28908 TNFRSF8
1
TNFRSF8 [plasma membrane]
(R-HSA-5668758)
0.527
2
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.524
2
UniProt:P25942 CD40
0.508
3
UniProt:Q9Y692 GMEB1
0.508
2
UniProt:P15314
1
Irf1 [nucleoplasm]
(R-MMU-983456)
0.499
2
UniProt:A2APF7 A2APF7
0.499
2
UniProt:Q9QYP6 AZI2
0.499
2
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